Publications by authors named "Scott Ribich"

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CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screen.
Nealia C House, Maxine M Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, Scott Ribich

NPJ Breast Cancer· December 2025

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Discovery of Kinesin KIF18A Inhibitor ATX020: Tactical Application of Silicon Atom Replacement.
Brian A Sparling, Hyelee Lee, Mary-Margaret Zablocki, Maureen M Lynes, Simina Grigoriu, Scott Ribich

ACS Med Chem Lett· November 2025

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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Matthew H Daniels, Jennifer Castro, Young-Tae Lee, Deepali Gotur, Kevin E Knockenhauer, Scott Ribich

J Med Chem· May 2025

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Profiling the Activity of the Potent and Highly Selective CDK2 Inhibitor BLU-222 Reveals Determinants of Response in CCNE1-Aberrant Ovarian and Endometrial Tumors.
Nealia C House, Victoria E Brown, Maxine Chen, Liang Yuan, Sydney L Moore, Scott Ribich

Cancer Res· April 2025

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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Gordon J Lockbaum, Maureen M Lynes, Sophie A Shen, Julie Liu, Nicholas Holt, Scott Ribich

Commun Biol· April 2025

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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair.
Jennifer Castro, Matthew H Daniels, David Brennan, Brian Johnston, Deepali Gotur, Scott Ribich

Cancer Res· February 2025

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CDK2 regulates collapsed replication fork repair in CCNE1-amplified ovarian cancer cells via homologous recombination.
Victoria E Brown, Sydney L Moore, Maxine Chen, Nealia House, Philip Ramsden, Scott Ribich

NAR Cancer· September 2023

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A Mass Spectrometric Assay of METTL3/METTL14 Methyltransferase Activity.
Shane M Buker, Zachary A Gurard-Levin, Benjamin D Wheeler, Michael D Scholle, April W Case, Scott Ribich

SLAS Discov· April 2020

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Anti-tumor Activity of the Type I PRMT Inhibitor, GSK3368715, Synergizes with PRMT5 Inhibition through MTAP Loss.
Andrew Fedoriw, Satyajit R Rajapurkar, Shane O'Brien, Sarah V Gerhart, Lorna H Mitchell, Scott A Ribich

Cancer Cell· July 2019

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Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
Michael J Thomenius, Jennifer Totman, Darren Harvey, Lorna H Mitchell, Thomas V Riera, Scott Ribich

PLoS One· December 2018

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RNA-modifying proteins as anticancer drug targets.
P Ann Boriack-Sjodin, Scott Ribich, Robert A Copeland

Nat Rev Drug Discov· June 2018

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Tazemetostat, an EZH2 inhibitor, in relapsed or refractory B-cell non-Hodgkin lymphoma and advanced solid tumours: a first-in-human, open-label, phase 1 study.
Antoine Italiano, Jean-Charles Soria, Maud Toulmonde, Jean-Marie Michot, Carlo Lucchesi, Scott Ribich

Lancet Oncol· May 2018

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Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma.
Allison E Drew, Oscar Moradei, Suzanne L Jacques, Nathalie Rioux, Ann P Boriack-Sjodin, Scott A Ribich

Sci Rep· December 2017

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EZH2 Inhibition by Tazemetostat Results in Altered Dependency on B-cell Activation Signaling in DLBCL.
Dorothy Brach, Danielle Johnston-Blackwell, Allison Drew, Trupti Lingaraj, Vinny Motwani, Scott A Ribich

Mol Cancer Ther· November 2017

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Drug Discovery and Chemical Biology of Cancer Epigenetics.
Scott Ribich, Darren Harvey, Robert A Copeland

Cell Chem Biol· September 2017

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Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Scott Ribich

PLoS One· July 2017

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Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: and Preclinical Models.
Elayne Chan-Penebre, Kelli Armstrong, Allison Drew, Alexandra R Grassian, Igor Feldman, Scott A Ribich

Mol Cancer Ther· May 2017

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Chemosensitive Relapse in Small Cell Lung Cancer Proceeds through an EZH2-SLFN11 Axis.
Eric E Gardner, Benjamin H Lok, Valentina E Schneeberger, Patrice Desmeules, Linde A Miles, Scott Ribich

Cancer Cell· February 2017

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Correction: Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.
Satoshi Kawano, Alexandra R Grassian, Masumi Tsuda, Sarah K Knutson, Natalie M Warholic, Scott Ribich

PLoS One· January 2017

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Structural Insights into Ternary Complex Formation of Human CARM1 with Various Substrates.
P Ann Boriack-Sjodin, Lei Jin, Suzanne L Jacques, Allison Drew, Chris Sneeringer, Scott Ribich

ACS Chem Biol· March 2016

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Structural and Kinetic Characterization of a Novel N-acetylated Aliphatic Amine Metabolite of the PRMT Inhibitor, EPZ011652.
Nathalie Rioux, Lorna H Mitchell, Philip Tiller, Katie Plant, Joanne Shaw, Scott Ribich

Drug Metab Dispos· July 2015

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models.
Elayne Chan-Penebre, Kristy G Kuplast, Christina R Majer, P Ann Boriack-Sjodin, Tim J Wigle, Scott A Ribich

Nat Chem Biol· June 2015

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Aryl Pyrazoles as Potent Inhibitors of Arginine Methyltransferases: Identification of the First PRMT6 Tool Compound.
Lorna H Mitchell, Allison E Drew, Scott A Ribich, Nathalie Rioux, Kerren K Swinger

ACS Med Chem Lett· June 2015

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The chemical chaperones tauroursodeoxycholic and 4-phenylbutyric acid accelerate thyroid hormone activation and energy expenditure.
Wagner S da-Silva, Scott Ribich, Rafael Arrojo e Drigo, Melany Castillo, Mary-Elizabeth Patti

FEBS Lett· February 2011

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Absence of thyroid hormone activation during development underlies a permanent defect in adaptive thermogenesis.
Jessica A Hall, Scott Ribich, Marcelo A Christoffolete, Gordana Simovic, Mayrin Correa-Medina

Endocrinology· September 2010

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