Publications by authors named "Scott Throner"

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Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.
Avipsa Ghosh, Afshan Ahmed, Konstantina Amoiradaki, Amber Y S Balazs, Bernard Barlaam, Scott Throner

J Med Chem· September 2025

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Discovery of TNG-6132, a potent, selective, and orally bioavailable USP1 inhibitor.
Scott Throner, Tianshu Feng, Jannik N Andersen, Madhavi Bandi, Justin L Engel

Bioorg Med Chem Lett· August 2025

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Characterization of TNG348: A Selective, Allosteric USP1 Inhibitor That Synergizes with PARP Inhibitors in Tumors with Homologous Recombination Deficiency.
Antoine Simoneau, Charlotte B Pratt, Hsin-Jung Wu, Shreya S Rajeswaran, Charlotte Grace Comer, Scott Throner

Mol Cancer Ther· May 2025

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Discovery of (2,4)-4-(()-2-Amino-3-methylbutanamido)-2-(4-boronobutyl)pyrrolidine-2-carboxylic Acid (AZD0011), an Actively Transported Prodrug of a Potent Arginase Inhibitor to Treat Cancer.
Scott N Mlynarski, Brian M Aquila, Susan Cantin, Steve Cook, Aatman Doshi, Scott Throner

J Med Chem· December 2024

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Ubiquitinated PCNA Drives USP1 Synthetic Lethality in Cancer.
Antoine Simoneau, Justin L Engel, Madhavi Bandi, Katherine Lazarides, Shangtao Liu, Scott Throner

Mol Cancer Ther· February 2023

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Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
James S Scott, Thomas A Moss, Amber Balazs, Bernard Barlaam, Jason Breed, Scott R Throner

J Med Chem· December 2020

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Discovery of (2)--[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.
Qibin Su, Erica Banks, Geraldine Bebernitz, Kirsten Bell, Cassandra F Borenstein, Scott Throner

J Med Chem· May 2020

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Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.
Neil P Grimster, Erica Anderson, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Scott Throner

J Med Chem· June 2018

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Design, Synthesis, and Biological Activity of Substrate Competitive SMYD2 Inhibitors.
Scott D Cowen, Daniel Russell, Leslie A Dakin, Huawei Chen, Nicholas A Larsen, Scott Throner

J Med Chem· December 2016

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Discovery and Preclinical Validation of [(11)C]AZ13153556, a Novel Probe for the Histamine Type 3 Receptor.
Magnus Schou, Katarina Varnäs, Anders Jureus, Charlotte Ahlgren, Jonas Malmquist, Scott R Throner

ACS Chem Neurosci· February 2016

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Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering.
Jeffrey W Johannes, Lynsie Almeida, Kevin Daly, Andrew D Ferguson, Shaun E Grosskurth, Scott Throner

Bioorg Med Chem Lett· December 2015

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Discovery of spirofused piperazine and diazepane amides as selective histamine-3 antagonists with in vivo efficacy in a mouse model of cognition.
Dean G Brown, Peter R Bernstein, Andrew Griffin, Steve Wesolowski, Denis Labrecque, Scott R Throner

J Med Chem· February 2014

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Azepines and piperidines with dual norepinephrine dopamine uptake inhibition and antidepressant activity.
Dean G Brown, Peter R Bernstein, Ye Wu, Rebecca A Urbanek, Christopher W Becker, Scott R Throner

ACS Med Chem Lett· January 2013

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Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).
Jeffrey G Varnes, Andrew P Marcus, Russell C Mauger, Scott R Throner, Valerie Hoesch

Bioorg Med Chem Lett· March 2011

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Discovery of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as selective antagonists of the kappa opioid receptor. Part 1.
Todd A Brugel, Reed W Smith, Michael Balestra, Christopher Becker, Thalia Daniels, Scott R Throner

Bioorg Med Chem Lett· October 2010

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SAR development of a series of 8-azabicyclo[3.2.1]octan-3-yloxy-benzamides as kappa opioid receptor antagonists. Part 2.
Todd A Brugel, Reed W Smith, Michael Balestra, Christopher Becker, Thalia Daniels, Scott R Throner

Bioorg Med Chem Lett· September 2010

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