Publications by authors named "Shane Roller"

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Recombinant Erwinia asparaginase (JZP458) in ALL/LBL: complete follow-up of the Children's Oncology Group AALL1931 study.
Luke Maese, Mignon L Loh, Mi Rim Choi, Shirali Agarwal, Etsuko Aoki, Shane Roller

Blood Adv· January 2025

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A 28-Day Toxicity Study of Tenofovir Alafenamide Hemifumarate by Subcutaneous Infusion in Rats and Dogs.
Doris Zane, Shane Roller, Josephine Shelton, Roshni Singh, Rachna Jain

Microbiol Spectr· September 2021

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Tenofovir Alafenamide for HIV Prevention: Review of the Proceedings from the Gates Foundation Long-Acting TAF Product Development Meeting.
Joseph W Romano, Marc M Baum, Zach R Demkovich, Frank Diana, Charles Dobard, Shane Roller

AIDS Res Hum Retroviruses· June 2021

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Engineering of a Potent, Long-Acting NPY2R Agonist for Combination with a GLP-1R Agonist as a Multi-Hormonal Treatment for Obesity.
Sam Lear, Elsa Pflimlin, Zhihong Zhou, David Huang, Sharon Weng, Shane Roller

J Med Chem· September 2020

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Identification of potent, nonabsorbable agonists of the calcium-sensing receptor for GI-specific administration.
Steven M Sparks, Paul K Spearing, Caroline J Diaz, David J Cowan, Channa Jayawickreme, Shane G Roller

Bioorg Med Chem Lett· October 2017

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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist.
Steven M Sparks, Christopher Aquino, Pierette Banker, Jon L Collins, David Cowan, Shane Roller

Bioorg Med Chem Lett· March 2017

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Discovery of a highly potent, nonabsorbable apical sodium-dependent bile acid transporter inhibitor (GSK2330672) for treatment of type 2 diabetes.
Yulin Wu, Christopher J Aquino, David J Cowan, Don L Anderson, Jeff L Ambroso, Shane G Roller

J Med Chem· June 2013

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Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists.
Subba R Katamreddy, Andrew J Carpenter, Carina E Ammala, Eric E Boros, Ron L Brashear, Shane G Roller

J Med Chem· December 2012

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Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: discovery of MK-2918.
Daniel V Paone, Diem N Nguyen, Anthony W Shaw, Christopher S Burgey, Craig M Potteiger, Shane Roller

Bioorg Med Chem Lett· May 2011

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Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality.
Michael R Wood, Kathy M Schirripa, June J Kim, Rodney A Bednar, John F Fay, Shane Roller

Bioorg Med Chem Lett· November 2010

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Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Christopher D Cox, Michael J Breslin, David B Whitman, John D Schreier, Georgia B McGaughey, Shane Roller

J Med Chem· July 2010

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Identification of potent, highly constrained CGRP receptor antagonists.
Craig A Stump, Ian M Bell, Rodney A Bednar, John F Fay, Steven N Gallicchio, Shane A Roller

Bioorg Med Chem Lett· April 2010

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Synthesis and SAR of Benzisothiazole- and Indolizine-β-d-glucopyranoside Inhibitors of SGLT2.
Huiqiang Zhou, Dana P Danger, Steven T Dock, Lora Hawley, Shane G Roller

ACS Med Chem Lett· April 2010

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Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist.
Ian M Bell, Steven N Gallicchio, Michael R Wood, Amy G Quigley, Craig A Stump, Shane Roller

ACS Med Chem Lett· April 2010

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Optimization of azepanone calcitonin gene-related peptide (CGRP) receptor antagonists: development of novel spiropiperidines.
Christopher S Burgey, Craig M Potteiger, James Z Deng, Scott D Mosser, Christopher A Salvatore, Shane Roller

Bioorg Med Chem Lett· November 2009

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Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility.
Michael R Wood, Kathy M Schirripa, June J Kim, Amy G Quigley, Craig A Stump, Shane Roller

Bioorg Med Chem Lett· October 2009

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The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Ian M Bell, Rodney A Bednar, Halea A Corcoran, John F Fay, Steven N Gallicchio, Shane A Roller

Bioorg Med Chem Lett· August 2009

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A novel class of achiral seco-analogs of CC-1065 and the duocarmycins: design, synthesis, DNA binding, and anticancer properties.
Stanley Kupchinsky, Sara Centioni, Tiffany Howard, John Trzupek, Shane Roller

Bioorg Med Chem· December 2004

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Mechanisms of idiosyncratic drug reactions: the case of felbamate.
Christine M Dieckhaus, Charles D Thompson, Shane G Roller, Timothy L Macdonald

Chem Biol Interact· November 2002

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Interaction between human serum albumin and the felbamate metabolites 4-Hydroxy-5-phenyl-[1,3]oxazinan-2-one and 2-phenylpropenal.
Shane G Roller, Christine M Dieckhaus, Webster L Santos, R Duane Sofia, Timothy L Macdonald

Chem Res Toxicol· June 2002

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