Publications by authors named "Simon Cobbold"

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Major histocompatibility class II in murine antigen presenting cells is modified with a branched K63 and K11-linked ubiquitin chain.
Haiyin Liu, Lauren Francis, Laura F Dagley, Simon A Cobbold, Andrew I Webb

Sci Rep· November 2025

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Functional characterisation of components in two Plasmodium falciparum Cullin-RING-Ligase complexes.
Danushka Marapana, Simon A Cobbold, Michal Pasternak, Gerald J Shami, Stuart A Ralph

Sci Rep· July 2025

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Differentiation of into latent forms is linked to central carbon metabolism and requires a GID/CTLH-type E3 ubiquitin ligase.
Alessandro D Uboldi, Sachin Khurana, Amalie A Jaywickrama, Sai Prasanna Lekkala-Lethakula, Amber Simonpietri, Simon A Cobbold

bioRxiv· July 2025

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The RBR E3 ubiquitin ligase HOIL-1 can ubiquitinate diverse non-protein substrates in vitro.
Xiangyi S Wang, Jenny Jiou, Anthony Cerra, Simon A Cobbold, Marco Jochem

Life Sci Alliance· June 2025

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Structure of human PINK1 at a mitochondrial TOM-VDAC array.
Sylvie Callegari, Nicholas S Kirk, Zhong Yan Gan, Toby Dite, Simon A Cobbold

Science· April 2025

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Mind bomb 2 limits inflammatory dermatitis in mutant mice independently of cell death.
Daniel S Simpson, Holly Anderton, Jumana Yousef, Vineet Vaibhav, Simon A Cobbold

PNAS Nexus· January 2024

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PTEX helps efficiently traffic haemoglobinases to the food vacuole in Plasmodium falciparum.
Thorey K Jonsdottir, Brendan Elsworth, Simon Cobbold, Mikha Gabriela, Ellen Ploeger

PLoS Pathog· July 2023

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Design and characterization of a heterobifunctional degrader of KEAP1.
Hao Chen, Nghi H Nguyen, Charlene M Magtoto, Simon A Cobbold, Grace M Bidgood

Redox Biol· February 2023

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Ubiquitylation of RIPK3 beyond-the-RHIM can limit RIPK3 activity and cell death.
Daniel Frank, Sarah E Garnish, Jarrod J Sandow, Ashley Weir, Lin Liu, Simon A Cobbold

iScience· July 2022

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Development of NanoLuc-targeting protein degraders and a universal reporter system to benchmark tag-targeted degradation platforms.
Christoph Grohmann, Charlene M Magtoto, Joel R Walker, Ngee Kiat Chua, Anna Gabrielyan, Simon A Cobbold

Nat Commun· April 2022

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Publisher Correction: Activation mechanism of PINK1.
Zhong Yan Gan, Sylvie Callegari, Simon A Cobbold, Thomas R Cotton, Michael J Mlodzianoski

Nature· March 2022

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Activation mechanism of PINK1.
Zhong Yan Gan, Sylvie Callegari, Simon A Cobbold, Thomas R Cotton, Michael J Mlodzianoski

Nature· February 2022

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Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216.
Thomas R Cotton, Simon A Cobbold, Jonathan P Bernardini, Lachlan W Richardson, Xiangyi S Wang

Mol Cell· February 2022

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Non-canonical metabolic pathways in the malaria parasite detected by isotope-tracing metabolomics.
Simon A Cobbold, Madel V Tutor, Philip Frasse, Emma McHugh, Markus Karnthaler

Mol Syst Biol· April 2021

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Metabolomic Analysis of Toxoplasma gondii Tachyzoites.
Elizabeth F B King, Simon A Cobbold, Alessandro D Uboldi, Christopher J Tonkin, Malcolm J McConville

Methods Mol Biol· January 2021

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The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides.
Gillian M Fisher, Simon A Cobbold, Andrew Jezewski, Emma F Carpenter, Megan Arnold

mBio· December 2020

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The natural function of the malaria parasite's chloroquine resistance transporter.
Sarah H Shafik, Simon A Cobbold, Kawthar Barkat, Sashika N Richards, Nicole S Lancaster

Nat Commun· August 2020

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The Metabolite Repair Enzyme Phosphoglycolate Phosphatase Regulates Central Carbon Metabolism and Fosmidomycin Sensitivity in Plasmodium falciparum.
Laure Dumont, Mark B Richardson, Phillip van der Peet, Danushka S Marapana, Tony Triglia, Simon A Cobbold

mBio· December 2019

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The multifunctional enzyme S-adenosylhomocysteine/methylthioadenosine nucleosidase is a key metabolic enzyme in the virulence of Salmonella enterica var Typhimurium.
Asma U Husna, Nancy Wang, Jonathan J Wilksch, Hayley J Newton, Dianna M Hocking, Simon A Cobbold

Biochem J· November 2019

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Decreased K13 Abundance Reduces Hemoglobin Catabolism and Proteotoxic Stress, Underpinning Artemisinin Resistance.
Tuo Yang, Lee M Yeoh, Madel V Tutor, Matthew W Dixon, Paul J McMillan, Simon A Cobbold

Cell Rep· November 2019

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A Family of Dual-Activity Glycosyltransferase-Phosphorylases Mediates Mannogen Turnover and Virulence in Leishmania Parasites.
M Fleur Sernee, Julie E Ralton, Tracy L Nero, Lukasz F Sobala, Joachim Kloehn, Simon A Cobbold

Cell Host Microbe· September 2019

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Delayed death in the malaria parasite Plasmodium falciparum is caused by disruption of prenylation-dependent intracellular trafficking.
Kit Kennedy, Simon A Cobbold, Eric Hanssen, Jakob Birnbaum, Natalie J Spillman

PLoS Biol· July 2019

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Determining the Mode of Action of Antimalarial Drugs Using Time-Resolved LC-MS-Based Metabolite Profiling.
Simon A Cobbold, Malcolm J McConville

Methods Mol Biol· June 2019

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Artemisinin kills malaria parasites by damaging proteins and inhibiting the proteasome.
Jessica L Bridgford, Stanley C Xie, Simon A Cobbold, Charisse Flerida A Pasaje, Susann Herrmann

Nat Commun· September 2018

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Methionine biosynthesis and transport are functionally redundant for the growth and virulence of Typhimurium.
Asma Ul Husna, Nancy Wang, Simon A Cobbold, Hayley J Newton, Dianna M Hocking

J Biol Chem· June 2018

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