Publications by authors named "Stephan M Hacker"

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Profiling the proteome-wide selectivity of diverse electrophiles.
Patrick R A Zanon, Fengchao Yu, Patricia Z Musacchio, Lisa Lewald, Michael Zollo, Stephan M Hacker

Nat Chem· November 2025

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Total syntheses of cyclohelminthol I-IV reveal a new cysteine-selective covalent reactive group.
Thomas T Paulsen, Anders E Kiib, Gustav J Wørmer, Stephan M Hacker, Thomas B Poulsen

Chem Sci· February 2025

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Development of Inhibitors, Probes, and PROTAC Provides a Complete Toolbox to Study PARK7 in the Living Cell.
Yuqing Jia, Merve Oyken, Robbert Q Kim, Rayman T N Tjokrodirijo, Arnoud H de Ru, Stephan M Hacker

J Med Chem· May 2024

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A Chemical Proteomic Strategy Reveals Inhibitors of Lipoate Salvage in Bacteria and Parasites.
Jan-Niklas Dienemann, Shu-Yu Chen, Manuel Hitzenberger, Montana L Sievert, Stephan M Hacker

Angew Chem Int Ed Engl· August 2023

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A chemical probe unravels the reactive proteome of health-associated catechols.
Angela Weigert Muñoz, Kevin M Meighen-Berger, Stephan M Hacker, Matthias J Feige, Stephan A Sieber

Chem Sci· August 2023

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The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21.
Esben B Svenningsen, Rasmus N Ottosen, Katrine H Jørgensen, Marija Nisavic, Camilla K Larsen, Stephan M Hacker

RSC Chem Biol· October 2022

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Competitive profiling of ligandable cysteines in with an organogold compound.
Claudia Schmidt, Michael Zollo, Riccardo Bonsignore, Angela Casini, Stephan M Hacker

Chem Commun (Camb)· May 2022

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SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.
Pascal Demange, Etienne Joly, Julien Marcoux, Patrick R A Zanon, Dymytrii Listunov, Stephan M Hacker

Elife· May 2022

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Eukaryotic catecholamine hormones influence the chemotactic control of by binding to the coupling protein CheW.
Angela Weigert Muñoz, Elisabeth Hoyer, Kilian Schumacher, Marianne Grognot, Katja M Taute, Stephan M Hacker

Proc Natl Acad Sci U S A· March 2022

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Chemical biology in drug discovery.
Stephan M Hacker, Claudia Jessen-Trefzer

Biol Chem· March 2022

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Promising reversible protein inhibitors kept on target.
Stephan M Hacker

Nature· March 2022

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A proteome-wide atlas of lysine-reactive chemistry.
Mikail E Abbasov, Madeline E Kavanagh, Taka-Aki Ichu, Michael R Lazear, Yongfeng Tao, Stephan M Hacker

Nat Chem· November 2021

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Publisher Correction: A proteome-wide atlas of lysine-reactive chemistry.
Mikail E Abbasov, Madeline E Kavanagh, Taka-Aki Ichu, Michael R Lazear, Yongfeng Tao, Stephan M Hacker

Nat Chem· November 2021

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HSP-90/kinase complexes are stabilized by the large PPIase FKB-6.
Siyuan Sima, Katalin Barkovits, Katrin Marcus, Lukas Schmauder, Stephan M Hacker

Sci Rep· June 2021

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Broad Spectrum Antibiotic Xanthocillin X Effectively Kills Dysregulation of Heme Biosynthesis.
Ines Hübner, Justin A Shapiro, Jörn Hoßmann, Jonas Drechsel, Stephan M Hacker

ACS Cent Sci· March 2021

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A tailored phosphoaspartate probe unravels CprR as a response regulator in interkingdom signaling.
Patrick W A Allihn, Mathias W Hackl, Christina Ludwig, Stephan M Hacker, Stephan A Sieber

Chem Sci· February 2021

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Light-Activatable, 2,5-Disubstituted Tetrazoles for the Proteome-wide Profiling of Aspartates and Glutamates in Living Bacteria.
Kathrin Bach, Bert L H Beerkens, Patrick R A Zanon, Stephan M Hacker

ACS Cent Sci· April 2020

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Degrasyn exhibits antibiotic activity against multi-resistant Staphylococcus aureus by modifying several essential cysteines.
Kyu Myung Lee, Philipp Le, Stephan A Sieber, Stephan M Hacker

Chem Commun (Camb)· March 2020

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Isotopically Labeled Desthiobiotin Azide (isoDTB) Tags Enable Global Profiling of the Bacterial Cysteinome.
Patrick R A Zanon, Lisa Lewald, Stephan M Hacker

Angew Chem Int Ed Engl· February 2020

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Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.
Philipp Le, Elena Kunold, Robert Macsics, Katharina Rox, Megan C Jennings, Stephan M Hacker

Nat Chem· February 2020

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Neocarzilin A Is a Potent Inhibitor of Cancer Cell Motility Targeting VAT-1 Controlled Pathways.
Carolin M-L Gleissner, Carolin L Pyka, Wolfgang Heydenreuter, Thomas F Gronauer, Carina Atzberger, Stephan M Hacker

ACS Cent Sci· July 2019

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Global profiling of lysine reactivity and ligandability in the human proteome.
Stephan M Hacker, Keriann M Backus, Michael R Lazear, Stefano Forli, Bruno E Correia

Nat Chem· December 2017

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Inhibitors of the Diadenosine Tetraphosphate Phosphorylase Rv2613c of Mycobacterium tuberculosis.
Kathrin H Götz, Stephan M Hacker, Daniel Mayer, Jan-Niklas Dürig, Steffen Stenger

ACS Chem Biol· October 2017

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Small-Molecule Inhibitors of the Tumor Suppressor Fhit.
Sandra Lange, Stephan M Hacker, Philipp Schmid, Martin Scheffner, Andreas Marx

Chembiochem· September 2017

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Phosphate-Modified Nucleotides for Monitoring Enzyme Activity.
Susanne Ermert, Andreas Marx, Stephan M Hacker

Top Curr Chem (Cham)· April 2017

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