Publications by authors named "Steven Knight"

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Asymmetric synthesis of potent and orally bioavailable thiophene-based EZH2 inhibitors.
Xinrong Tian, Ken Newlander, Louis LaFrance, James Mack, James Brackley, Steven D Knight

Bioorg Med Chem Lett· November 2025

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Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
Xinrong Tian, Dominic Suarez, Douglas Thomson, William Li, Elizabeth A King, Steven Knight

J Med Chem· November 2022

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A review of alternative intravenous acetylcysteine regimens for acetaminophen overdose.
Kevin Burnham, Tianrui Yang, Haleigh Smith, Steven Knight

Expert Rev Clin Pharmacol· October 2021

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Opioid Overdoses for Recently Incarcerated Individuals: Toxicology Results and Risk Evaluations.
Patrick Hegde, Jacob Shreffler, Steven Knight, Raymond Orthober, Martin Huecker

Subst Use Misuse· June 2021

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Signaling function of PRC2 is essential for TCR-driven T cell responses.
Marc-Werner Dobenecker, Joon Seok Park, Jonas Marcello, Michael T McCabe, Richard Gregory, Steven D Knight

J Exp Med· April 2018

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Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT).
Hongfang Yang, Patricia F Medeiros, Kaushik Raha, Patricia Elkins, Kenneth E Lind, Steven D Knight

ACS Med Chem Lett· May 2015

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A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.
Heidi M Ott, Alan P Graves, Melissa B Pappalardi, Michael Huddleston, Wendy S Halsey, Steven D Knight

Mol Cancer Ther· December 2014

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Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis.
Ricarda A L Menke, Sonja Körner, Nicola Filippini, Gwenaëlle Douaud, Steven Knight

Brain· September 2014

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Non-invasive imaging of carotid arterial restenosis using 3T cardiovascular magnetic resonance.
Alistair C Lindsay, Luca Biasiolli, Steven Knight, Colin Cunnington, Matthew D Robson

J Cardiovasc Magn Reson· January 2014

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Myelin imaging in amyotrophic and primary lateral sclerosis.
Shannon Kolind, Rakesh Sharma, Steven Knight, Heidi Johansen-Berg, Kevin Talbot

Amyotroph Lateral Scler Frontotemporal Degener· December 2013

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Recent progress in the discovery of small-molecule inhibitors of the HMT EZH2 for the treatment of cancer.
Sharad K Verma, Steven D Knight

Future Med Chem· September 2013

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Whole-brain magnetic resonance spectroscopic imaging measures are related to disability in ALS.
Charlotte J Stagg, Steven Knight, Kevin Talbot, Mark Jenkinson, Andrew A Maudsley

Neurology· February 2013

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Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2.
Sharad K Verma, Xinrong Tian, Louis V LaFrance, Céline Duquenne, Dominic P Suarez, Steven D Knight

ACS Med Chem Lett· December 2012

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Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis.
Gwenaëlle Douaud, Nicola Filippini, Steven Knight, Kevin Talbot, Martin R Turner

Brain· December 2011

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Discovery of the First Potent and Selective Inhibitor of Centromere-Associated Protein E: GSK923295.
Xiangping Qian, Andrew McDonald, Han-Jie Zhou, Nicholas D Adams, Cynthia A Parrish, Steven D Knight

ACS Med Chem Lett· April 2010

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin.
Steven D Knight, Nicholas D Adams, Joelle L Burgess, Amita M Chaudhari, Michael G Darcy

ACS Med Chem Lett· April 2010

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Antitumor activity of an allosteric inhibitor of centromere-associated protein-E.
Kenneth W Wood, Latesh Lad, Lusong Luo, Xiangping Qian, Steven D Knight

Proc Natl Acad Sci U S A· March 2010

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Recent progress in the identification and clinical evaluation of inhibitors of the mitotic kinesin KSP.
Steven D Knight, Cynthia A Parrish

Curr Top Med Chem· September 2008

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Urotensin-II receptor antagonists: synthesis and SAR of N-cyclic azaalkyl benzamides.
Jian Jin, Ming An, Anthony Sapienza, Nambi Aiyar, Diane Naselsky, Steven D Knight

Bioorg Med Chem Lett· July 2008

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Novel ATP-competitive kinesin spindle protein inhibitors.
Cynthia A Parrish, Nicholas D Adams, Kurt R Auger, Joelle L Burgess, Jeffrey D Carson, Steven D Knight

J Med Chem· October 2007

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Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375.
Stephen A Douglas, David J Behm, Nambi V Aiyar, Diane Naselsky, Jyoti Disa, Steven D Knight

Br J Pharmacol· July 2005

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Aminoalkoxybenzyl pyrrolidines as novel human urotensin-II receptor antagonists.
Jian Jin, Dashyant Dhanak, Steven D Knight, Katherine Widdowson, Nambi Aiyar

Bioorg Med Chem Lett· July 2005

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Extending polymerization time of polymethylmethacrylate cement in percutaneous vertebroplasty with ice bath cooling.
Ram Chavali, Rick Resijek, Steven K Knight, In Sup Choi

AJNR Am J Neuroradiol· March 2003

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Pharmacological characterization of SB-710411 (Cpa-c[D-Cys-Pal-D-Trp-Lys-Val-Cys]-Cpa-amide), a novel peptidic urotensin-II receptor antagonist.
David J Behm, Christopher L Herold, Eliot H Ohlstein, Steven D Knight, Dashyant Dhanak

Br J Pharmacol· October 2002

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