Publications by authors named "Steven Shia"

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Structural and Biological Basis of Small Molecule Inhibition of LpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
Xiaolei Ma, Ramadevi Prathapam, Charles Wartchow, Barbara Chie-Leon, Chi-Min Ho, Steven Shia

ACS Infect Dis· June 2020

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Two Distinct Mechanisms of Inhibition of LpxA Acyltransferase Essential for Lipopolysaccharide Biosynthesis.
Wooseok Han, Xiaolei Ma, Carl J Balibar, Christopher M Baxter Rath, Bret Benton, Steven Shia

J Am Chem Soc· March 2020

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Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Yingnan Zhang, Mark Ultsch, Nicholas J Skelton, Daniel J Burdick, Maureen H Beresini, Steven Shia

Nat Struct Mol Biol· October 2017

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Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Jun Liang, Anne Van Abbema, Mercedesz Balazs, Kathy Barrett, Leo Berezhkovsky, Steven Shia

Bioorg Med Chem Lett· September 2017

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Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.
Xiaolei Ma, Lili Xie, Charles Wartchow, Robert Warne, Yongjin Xu, Steven Shia

Sci Rep· August 2017

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Structure-guided enzymology of the lipid A acyltransferase LpxM reveals a dual activity mechanism.
Dustin Dovala, Christopher M Rath, Qijun Hu, William S Sawyer, Steven Shia

Proc Natl Acad Sci U S A· October 2016

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Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.
Lili Xie, Charles Wartchow, Steven Shia, Kyoko Uehara, Micah Steffek

J Biol Chem· January 2016

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Structural basis of the broadly neutralizing anti-interferon-α antibody rontalizumab.
Brigitte Maurer, Ivan Bosanac, Steven Shia, Mandy Kwong, Racquel Corpuz

Protein Sci· September 2015

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Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Richard M Pastor, Jason D Burch, Steven Magnuson, Daniel F Ortwine, Yuan Chen, Steven Shia

Bioorg Med Chem Lett· June 2014

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Generation and characterization of a unique reagent that recognizes a panel of recombinant human monoclonal antibody therapeutics in the presence of endogenous human IgG.
Xiangdan Wang, Valerie Quarmby, Carl Ng, Anan Chuntharapai, Theresa Shek, Steven Shia

MAbs· January 2014

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Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
Yingnan Zhang, Charles Eigenbrot, Lijuan Zhou, Steven Shia, Wei Li

J Biol Chem· January 2014

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Structure-based design and synthesis of potent benzothiazole inhibitors of interleukin-2 inducible T cell kinase (ITK).
Colin H MacKinnon, Kevin Lau, Jason D Burch, Yuan Chen, Jonathon Dines, Steven Shia

Bioorg Med Chem Lett· December 2013

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Design and evaluation of novel 8-oxo-pyridopyrimidine Jak1/2 inhibitors.
Sharada Labadie, Kathy Barrett, Wade S Blair, Christine Chang, Gauri Deshmukh, Steven Shia

Bioorg Med Chem Lett· November 2013

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Lead identification of novel and selective TYK2 inhibitors.
Jun Liang, Vickie Tsui, Anne Van Abbema, Liang Bao, Kathy Barrett, Steven Shia

Eur J Med Chem· September 2013

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Identification of C-2 hydroxyethyl imidazopyrrolopyridines as potent JAK1 inhibitors with favorable physicochemical properties and high selectivity over JAK2.
Mark Zak, Christopher A Hurley, Stuart I Ward, Philippe Bergeron, Kathy Barrett, Steven Shia

J Med Chem· June 2013

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Lead optimization of a 4-aminopyridine benzamide scaffold to identify potent, selective, and orally bioavailable TYK2 inhibitors.
Jun Liang, Anne van Abbema, Mercedesz Balazs, Kathy Barrett, Leo Berezhkovsky, Steven Shia

J Med Chem· June 2013

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Structure-based discovery of C-2 substituted imidazo-pyrrolopyridine JAK1 inhibitors with improved selectivity over JAK2.
Sharada Labadie, Peter S Dragovich, Kathy Barrett, Wade S Blair, Philippe Bergeron, Steven Shia

Bioorg Med Chem Lett· December 2012

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Discovery and optimization of C-2 methyl imidazopyrrolopyridines as potent and orally bioavailable JAK1 inhibitors with selectivity over JAK2.
Mark Zak, Rohan Mendonca, Mercedesz Balazs, Kathy Barrett, Philippe Bergeron, Steven Shia

J Med Chem· July 2012

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Identification of imidazo-pyrrolopyridines as novel and potent JAK1 inhibitors.
Janusz J Kulagowski, Wade Blair, Richard J Bull, Christine Chang, Gauri Deshmukh, Steven Shia

J Med Chem· June 2012

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A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies.
Gabriele Schaefer, Lauric Haber, Lisa M Crocker, Steven Shia, Lily Shao

Cancer Cell· October 2011

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Unraveling the allosteric mechanism of serine protease inhibition by an antibody.
Rajkumar Ganesan, Charles Eigenbrot, Yan Wu, Wei-Ching Liang, Steven Shia

Structure· December 2009

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Structural insight into distinct mechanisms of protease inhibition by antibodies.
Yan Wu, Charles Eigenbrot, Wei-Ching Liang, Scott Stawicki, Steven Shia

Proc Natl Acad Sci U S A· December 2007

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Aspartate isomerization in the complementarity-determining regions of two closely related monoclonal antibodies.
Aditya A Wakankar, Ronald T Borchardt, Charles Eigenbrot, Steven Shia, Y John Wang

Biochemistry· February 2007

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Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B.
Steven Shia, Jennifer Stamos, Daniel Kirchhofer, Bin Fan, Judy Wu

J Mol Biol· March 2005

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