Publications by authors named "Swee Sharp"

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Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function.
Swee Y Sharp, Marianna Martella, Sabrina D'Agostino, Christopher I Milton, George Ward

Nat Commun· November 2024

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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
A Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, Angela Hayes, Loredana Pellegrino

J Med Chem· April 2023

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Solution structure of the Hop TPR2A domain and investigation of target druggability by NMR, biochemical and in silico approaches.
John F Darby, Lewis R Vidler, Peter J Simpson, Bissan Al-Lazikani, Stephen J Matthews, Swee Y Sharp

Sci Rep· September 2020

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Correction: Silencing of HSP90 Cochaperone AHA1 Expression Decreases Client Protein Activation and Increases Cellular Sensitivity to the HSP90 Inhibitor 17-Allylamino-17-Demethoxygeldanamycin.
Joanna L Holmes, Swee Y Sharp, Steve Hobbs, Paul Workman

Cancer Res· January 2019

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Correction: Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors.
Swee Y Sharp, Kathy Boxall, Martin Rowlands, Chrisostomos Prodromou, S Mark Roe

Cancer Res· January 2019

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Correction to: An in vitro and in vivo study of the combination of the heat shock protein inhibitor 17-allylamino-17-demethoxygeldanamycin and carboplatin in human ovarian cancer models.
Udai Banerji, Nivedita Sain, Swee Y Sharp, Melanie Valenti, Yasmin Asad

Cancer Chemother Pharmacol· November 2018

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Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor.
Steven R Whittaker, Clare Barlow, Mathew P Martin, Caterina Mancusi, Steve Wagner, Swee Sharp

Mol Oncol· March 2018

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
Nicola E A Chessum, Swee Y Sharp, John J Caldwell, A Elisa Pasqua, Birgit Wilding

J Med Chem· February 2018

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
Matthew D Cheeseman, Nicola E A Chessum, Carl S Rye, A Elisa Pasqua, Michael J Tucker, Swee Y Sharp

J Med Chem· January 2017

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
Carl S Rye, Nicola E A Chessum, Scott Lamont, Kurt G Pike, Paul Faulder, Swee Y Sharp

Medchemcomm· August 2016

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Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells.
Roberta Ferraldeschi, Jonathan Welti, Marissa V Powers, Wei Yuan, Tomoko Smyth, Swee Sharp

Cancer Res· May 2016

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Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Alpa Patel, Swee Y Sharp, Katelan Hall, William Lewis, Malcolm F G Stevens

Org Biomol Chem· April 2016

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Co-crystalization and in vitro biological characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors.
Swee Y Sharp, S Mark Roe, Egidijus Kazlauskas, Inga Cikotienė, Paul Workman

PLoS One· March 2013

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Effects of HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) on NEU/HER2 overexpressing mammary tumours in MMTV-NEU-NT mice monitored by Magnetic Resonance Spectroscopy.
Loreta M Rodrigues, Yuen-Li Chung, Nada M S Al Saffar, Swee Y Sharp, Laura E Jackson

BMC Res Notes· May 2012

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HSP90 inhibition: two-pronged exploitation of cancer dependencies.
Jon Travers, Swee Sharp, Paul Workman

Drug Discov Today· March 2012

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Targeting the Hsp90 molecular chaperone with novel macrolactams. Synthesis, structural, binding, and cellular studies.
James E H Day, Swee Y Sharp, Martin G Rowlands, Wynne Aherne, Angela Hayes

ACS Chem Biol· December 2011

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MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.
Nathalie Gaspar, Lynley Marshall, Lara Perryman, Dorine A Bax, Suzanne E Little, Swee Y Sharp

Cancer Res· November 2010

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Inhibition of Hsp90 with resorcylic acid macrolactones: synthesis and binding studies.
James E H Day, Swee Y Sharp, Martin G Rowlands, Wynne Aherne, William Lewis

Chemistry· September 2010

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Modulation of melanoma cell phospholipid metabolism in response to heat shock protein 90 inhibition.
Mounia Beloueche-Babari, Vaitha Arunan, L Elizabeth Jackson, Nina Perusinghe, Swee Y Sharp

Oncotarget· July 2010

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The association of CCND1 overexpression and cisplatin resistance in testicular germ cell tumors and other cancers.
Elodie E Noel, Marc Yeste-Velasco, Xueying Mao, Jackie Perry, Sakunthala C Kudahetti, Swee Sharp

Am J Pathol· June 2010

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Mechanistic evaluation of the novel HSP90 inhibitor NVP-AUY922 in adult and pediatric glioblastoma.
Nathalie Gaspar, Swee Y Sharp, Suzanne A Eccles, Sharon Gowan, Sergey Popov

Mol Cancer Ther· May 2010

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Targeting the Hsp90 chaperone: synthesis of novel resorcylic acid macrolactone inhibitors of Hsp90.
James E H Day, Swee Y Sharp, Martin G Rowlands, Wynne Aherne, Paul Workman

Chemistry· March 2010

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EGFRvIII deletion mutations in pediatric high-grade glioma and response to targeted therapy in pediatric glioma cell lines.
Dorine A Bax, Nathalie Gaspar, Suzanne E Little, Lynley Marshall, Lara Perryman, Swee Y Sharp

Clin Cancer Res· September 2009

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Combining hit identification strategies: fragment-based and in silico approaches to orally active 2-aminothieno[2,3-d]pyrimidine inhibitors of the Hsp90 molecular chaperone.
Paul A Brough, Xavier Barril, Jenifer Borgognoni, Patrick Chene, Nicholas G M Davies, Swee Y Sharp

J Med Chem· August 2009

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Acquired resistance to 17-allylamino-17-demethoxygeldanamycin (17-AAG, tanespimycin) in glioblastoma cells.
Nathalie Gaspar, Swee Y Sharp, Simon Pacey, Chris Jones, Michael Walton

Cancer Res· March 2009

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