Publications by authors named "Ted Yednock"

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Targeting C1q prevents microglia-mediated synaptic removal in neuropathic pain.
Noosha Yousefpour, Shannon N Tansley, Samantha Locke, Behrang Sharif, Marc Parisien, Ted Yednock

Nat Commun· May 2025

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Results From a Phase 1 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of ANX005, a C1q Inhibitor, in Patients With Guillain-Barré Syndrome.
Quazi Deen Mohammad, Zhahirul Islam, Nowshin Papri, Shoma Hayat, Israt Jahan, Ted Yednock

J Peripher Nerv Syst· March 2025

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Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.
Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Ted Yednock

Nat Med· November 2023

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Author Correction: Microglia and complement mediate early corticostriatal synapse loss and cognitive dysfunction in Huntington's disease.
Daniel K Wilton, Kevin Mastro, Molly D Heller, Frederick W Gergits, Carly Rose Willing, Ted Yednock

Nat Med· November 2023

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Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye Disease: Results from Phase I Studies in Glaucoma.
Yang Sun, David Wirta, Wendy Murahashi, Vidhu Mathur, Sethu Sankaranarayanan, Ted Yednock

Ophthalmol Sci· June 2023

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Pharmacokinetic and Target Engagement Measures of ANX007, an Anti-C1q Antibody Fragment, Following Intravitreal Administration in Nonhuman Primates.
Anita Grover, Sethu Sankaranarayanan, Vidhu Mathur, Poojan Suri, Haiyan Qiu, Ted Yednock

Invest Ophthalmol Vis Sci· February 2023

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C1q and the classical complement cascade in geographic atrophy secondary to age-related macular degeneration.
Ted Yednock, Donald S Fong, Eleonora M Lad

Int J Retina Vitreous· November 2022

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Complement factor C1q mediates sleep spindle loss and epileptic spikes after mild brain injury.
Stephanie S Holden, Fiorella C Grandi, Oumaima Aboubakr, Bryan Higashikubo, Frances S Cho, Ted Yednock

Science· September 2021

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The Classical Complement Pathway Mediates Microglia-Dependent Remodeling of Spinal Motor Circuits during Development and in SMA.
Aleksandra Vukojicic, Nicolas Delestrée, Emily V Fletcher, John G Pagiazitis, Sethu Sankaranarayanan, Ted A Yednock

Cell Rep· December 2019

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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Ted Yednock

Sci Rep· November 2019

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Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration.
Haihan Jiao, Matt Rutar, Nilisha Fernando, Ted Yednock, Sethu Sankaranarayanan

Mol Neurodegener· August 2018

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Nonclinical Development of ANX005: A Humanized Anti-C1q Antibody for Treatment of Autoimmune and Neurodegenerative Diseases.
Janice A Lansita, Kirsten M Mease, Haiyan Qiu, Ted Yednock, Sethu Sankaranarayanan

Int J Toxicol· July 2018

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C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy.
Rhona McGonigal, Madeleine E Cunningham, Denggao Yao, Jennifer A Barrie, Sethu Sankaranarayanan, Ted A Yednock

Acta Neuropathol Commun· March 2016

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Melanoma cell adhesion molecule-positive CD8 T lymphocytes mediate central nervous system inflammation.
Catherine Larochelle, Marc-André Lécuyer, Jorge Ivan Alvarez, Marc Charabati, Olivia Saint-Laurent, Ted Yednock

Ann Neurol· July 2015

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Systems-based analyses of brain regions functionally impacted in Parkinson's disease reveals underlying causal mechanisms.
Brigit E Riley, Shyra J Gardai, Dorothea Emig-Agius, Marina Bessarabova, Alexander E Ivliev, Ted Yednock

PLoS One· May 2015

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Ted A Yednock

PLoS One· October 2014

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Elevated alpha-synuclein impairs innate immune cell function and provides a potential peripheral biomarker for Parkinson's disease.
Shyra J Gardai, Wenxian Mao, Birgitt Schüle, Michael Babcock, Sue Schoebel, Ted Yednock

PLoS One· June 2014

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Vascular alterations in PDAPP mice after anti-Aβ immunotherapy: Implications for amyloid-related imaging abnormalities.
Wagner Zago, Sally Schroeter, Teresa Guido, Karen Khan, Peter Seubert, Ted Yednock

Alzheimers Dement· October 2013

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Orally available and efficacious α4β1/α4β7 integrin inhibitors.
Ying-zi Xu, Jenifer L Smith, Christopher M Semko, Kassandra I Rossiter, Juri Y Fukuda, Ted A Yednock

Bioorg Med Chem Lett· August 2013

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Raymond A Ng, Minghua Sun, Simeon Bowers, Roy K Hom, Gary D Probst, Ted A Yednock

Bioorg Med Chem Lett· August 2013

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Ted A Yednock

J Med Chem· July 2013

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PEG conjugates of potent α4 integrin inhibitors, maintaining sustained levels and bioactivity in vivo, following subcutaneous administration.
Jenifer L Smith, Kassandra I Rossiter, Christopher M Semko, Ying-Zi Xu, David A Quincy, Ted A Yednock

Bioorg Med Chem Lett· July 2013

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Arylsulfonamide pyrimidines as VLA-4 antagonists.
Ying-Zi Xu, Andrei W Konradi, Frederique Bard, Michael Dappen, Lilibeth Dofiles, Ted Yednock

Bioorg Med Chem Lett· May 2013

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Sustained levels of antibodies against Aβ in amyloid-rich regions of the CNS following intravenous dosing in human APP transgenic mice.
Frédérique Bard, Michael Fox, Stuart Friedrich, Peter Seubert, Dale Schenk, Ted Yednock

Exp Neurol· November 2012

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Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system.
Catherine Larochelle, Romain Cayrol, Hania Kebir, Jorge Ivan Alvarez, Marc-André Lécuyer, Ted Yednock

Brain· October 2012

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