Publications by authors named "Tim Cawston"

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Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage.
Wang Hui, David A Young, Andrew D Rowan, Xin Xu, Tim E Cawston

Ann Rheum Dis· February 2016

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Leptin produced by joint white adipose tissue induces cartilage degradation via upregulation and activation of matrix metalloproteinases.
Wang Hui, Gary J Litherland, Martina S Elias, Gareth I Kitson, Tim E Cawston

Ann Rheum Dis· March 2012

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Baseline serum MMP-3 levels in patients with Rheumatoid Arthritis are still independently predictive of radiographic progression in a longitudinal observational cohort at 8 years follow up.
Mark Houseman, Catherine Potter, Nicola Marshall, Rachel Lakey, Tim Cawston

Arthritis Res Ther· February 2012

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Lipophilic statins prevent matrix metalloproteinase-mediated cartilage collagen breakdown by inhibiting protein geranylgeranylation.
Matt J Barter, Wang Hui, Rachel L Lakey, John B Catterall, Tim E Cawston

Ann Rheum Dis· December 2010

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Lithium protects cartilage from cytokine-mediated degradation by reducing collagen-degrading MMP production via inhibition of the P38 mitogen-activated protein kinase pathway.
Wang Hui, Gary J Litherland, Matthew Jefferson, Matt J Barter, Martina S Elias, Tim E Cawston

Rheumatology (Oxford)· November 2010

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HDAC-mediated control of ERK- and PI3K-dependent TGF-β-induced extracellular matrix-regulating genes.
Matt J Barter, Leon Pybus, Gary J Litherland, Andrew D Rowan, Ian M Clark, Tim E Cawston

Matrix Biol· September 2010

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Matriptase is a novel initiator of cartilage matrix degradation in osteoarthritis.
Jennifer M Milner, Amit Patel, Rose K Davidson, Tracey E Swingler, Antoine Desilets, Tim E Cawston

Arthritis Rheum· July 2010

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Assay of matrix metalloproteinases against matrix substrates.
Tim E Cawston, Rachel L Lakey, Andrew D Rowan

Methods Mol Biol· April 2010

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In vitro model of cartilage degradation.
Wang Hui, Tim E Cawston

Methods Mol Biol· April 2010

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Proteinases involved in matrix turnover during cartilage and bone breakdown.
Tim E Cawston, David A Young

Cell Tissue Res· January 2010

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Sulfasalazine blocks the release of proteoglycan and collagen from cytokine stimulated cartilage and down-regulates metalloproteinases.
Rachel L Lakey, Tim E Cawston

Rheumatology (Oxford)· October 2009

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A novel paradigm for dendritic cells as effectors of cartilage destruction.
Rachel L Lakey, Tanya G Morgan, Andrew D Rowan, John D Isaacs, Tim E Cawston

Rheumatology (Oxford)· May 2009

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Measurement of activity of collagenolytic MMP and inhibitors of MMPs using radiolabeled collagen substrate.
Tim E Cawston

Nat Protoc· April 2009

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Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent.
Gary J Litherland, Craig Dixon, Rachel L Lakey, Timothy Robson, Debra Jones, Tim E Cawston

J Biol Chem· May 2008

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Assessment of collagenase activity in cartilage.
Tim E Cawston, Tanya G Morgan

Methods Mol Med· December 2007

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Biomarkers predict radiographic progression in early rheumatoid arthritis and perform well compared with traditional markers.
Steven Young-Min, Tim Cawston, Nicola Marshall, David Coady, Stephan Christgau

Arthritis Rheum· October 2007

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Research in hand osteoarthritis: time for reappraisal and demand for new strategies. An opinion paper.
Margreet Kloppenburg, Tanja Stamm, Iain Watt, Franz Kainberger, Tim E Cawston

Ann Rheum Dis· September 2007

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Activity of matrix metalloproteinase-9 against native collagen types I and III.
Heather F Bigg, Andrew D Rowan, Michael D Barker, Tim E Cawston

FEBS J· March 2007

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Metalloproteinase and inhibitor expression profiling of resorbing cartilage reveals pro-collagenase activation as a critical step for collagenolysis.
Jennifer M Milner, Andrew D Rowan, Tim E Cawston, David A Young

Arthritis Res Ther· February 2007

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The phosphodiesterase type IV inhibitor cilomilast decreases pro-inflammatory cytokine production from primary bronchial epithelial cells in lung transplantation patients.
Des M Murphy, Chris Ward, Ian A Forrest, Gail Pritchard, Debbie Jones, Tim E Cawston

J Heart Lung Transplant· December 2006

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Understanding the role of tissue degrading enzymes and their inhibitors in development and disease.
Tim E Cawston, Amy J Wilson

Best Pract Res Clin Rheumatol· October 2006

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The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation.
Heather F Bigg, Robin Wait, Andrew D Rowan, Tim E Cawston

J Biol Chem· July 2006

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A model of inflammatory arthritis highlights a role for oncostatin M in pro-inflammatory cytokine-induced bone destruction via RANK/RANKL.
Wang Hui, Tim E Cawston, Carl D Richards, Andrew D Rowan

Arthritis Res Ther· March 2006

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Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases.
Jennifer M Milner, Tim E Cawston

Curr Drug Targets Inflamm Allergy· June 2005

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Cytokine synergy, collagenases and cartilage collagen breakdown.
Tim E Cawston, Jenny M Milner, Jon B Catterall, Andrew D Rowan

Biochem Soc Symp· February 2004

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