Publications by authors named "Timothy Block"

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Small molecule HBV RNA destabilizing drugs: Drugs of the future or compounds from the past?
Timothy M Block, Dimitar Gotchev, Yanming Du

Antiviral Res· December 2025

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Detection of Circulating mRNA Variants in Hepatocellular Carcinoma Patients Using Targeted RNAseq.
Daniel Zezulinski, Maarouf A Hoteit, David E Kaplan, Angela Simeone, Tingting Zhan, Timothy M Block

Liver Cancer· October 2025

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HBV-specific T-cell function is nonenhanced by tenofovir-induced decline in HBV viremia or HBsAg titer in chronic hepatitis B.
Daniel Traum, David K Wong, Daryl T Lau, Richard K Sterling, Norah A Terrault, Timothy M Block

Hepatol Commun· June 2025

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Hepato-selective dihydroquinolizinones active against hepatitis A virus in vitro and in vivo.
Ichiro Misumi, Zhizhou Yue, Zhengyuan Jiang, Anilkumar Karampoori, Jason K Whitmire, Timothy Block

Antiviral Res· May 2025

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New potent HBV replication inhibitors for the management of chronic hepatitis B are needed.
Timothy M Block, Ju-Tao Guo, Fabien Zoulim, Charles M Rice, Chloe L Thio, Peter D Block

Nat Rev Gastroenterol Hepatol· March 2025

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"PROTAC" modified dihydroquinolizinones (DHQs) that cause degradation of PAPD-5 and inhibition of hepatitis A virus and hepatitis B virus, in vitro.
You Li, Nicky Hwang, Andrew Snedeker, Stanley M Lemon, Daisy Noe, Timothy Block

Bioorg Med Chem Lett· April 2024

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Opportunities to address gaps in early detection and improve outcomes of liver cancer.
Brian McMahon, Chari Cohen, Robert S Brown, Hashem El-Serag, George N Ioannou, Timothy Block

JNCI Cancer Spectr· May 2023

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Circulating messenger RNA variants as a potential biomarker for surveillance of hepatocellular carcinoma.
Timothy Block, Daniel Zezulinski, David E Kaplan, Jingqiao Lu, Samantha Zanine

Front Oncol· December 2022

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A roadmap for serum biomarkers for hepatitis B virus: current status and future outlook.
Anna Kramvis, Kyong-Mi Chang, Maura Dandri, Patrizia Farci, Dieter Glebe, Timothy M Block

Nat Rev Gastroenterol Hepatol· November 2022

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Letter to the editor: Importance of universal screening for chronic hepatitis B infection in adults in the United States.
Chari Cohen, Kate Moraras, Michalea Jackson, Maureen Kamischke, Robert G Gish, Timothy M Block

Hepatology· April 2022

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Prospects for the Global Elimination of Hepatitis B.
Timothy M Block, Kyong-Mi Chang, Ju-Tao Guo

Annu Rev Virol· September 2021

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Hepatoselective Dihydroquinolizinone Bis-acids for HBsAg mRNA Degradation.
Nicky Hwang, Liren Sun, Daisy Noe, Patrick Y S Lam, Tianlun Zhou, Timothy M Block

ACS Med Chem Lett· July 2021

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Common concerns, barriers to care, and the lived experience of individuals with hepatitis B: a qualitative study.
Catherine Freeland, Sean Farrell, Priyanka Kumar, Maureen Kamischke, Michaela Jackson, Timothy M Block

BMC Public Health· May 2021

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Highly multiplexed 2-dimensional imaging mass cytometry analysis of HBV-infected liver.
Daniel Traum, Yue J Wang, Kathleen B Schwarz, Jonathan Schug, David Kh Wong, Timothy M Block

JCI Insight· April 2021

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Host RNA quality control as a hepatitis B antiviral target.
Timothy M Block, John A T Young, Hassan Javanbakht, Michael J Sofia, Tianlun Zhou

Antiviral Res· February 2021

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Biomarkers for the Early Detection of Hepatocellular Carcinoma.
Neehar D Parikh, Anand S Mehta, Amit G Singal, Timothy Block, Jorge A Marrero

Cancer Epidemiol Biomarkers Prev· December 2020

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The Dihydroquinolizinone Compound RG7834 Inhibits the Polyadenylase Function of PAPD5 and PAPD7 and Accelerates the Degradation of Matured Hepatitis B Virus Surface Protein mRNA.
Liren Sun, Fang Zhang, Fang Guo, Fei Liu, Jessie Kulsuptrakul, Timothy Block

Antimicrob Agents Chemother· December 2020

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Scalable Synthesis, In Vitro cccDNA Reduction, and In Vivo Antihepatitis B Virus Activity of a Phosphonomethoxydeoxythreosyl Adenine Prodrug.
Min Luo, Shuo Wu, Raj Kalkeri, Roger G Ptak, Tianlun Zhou, Timothy Block

J Med Chem· November 2020

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Profiling the circulating mRNA transcriptome in human liver disease.
Aejaz Sayeed, Brielle E Dalvano, David E Kaplan, Usha Viswanathan, John Kulp, Timothy Block

Oncotarget· June 2020

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Outcome of Electronic Order Alert Intervention Relative to Toxigenic Clostridium difficile PCR Analysis and Hospital-Onset C difficile Infection in a Multihospital Health Care System.
Erik Munson, Sonia Rodriguez, Nancy Riederer, Kimber L Munson, Denise Block, Timothy K Block

Am J Clin Pathol· May 2019

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Application of the Doylestown algorithm for the early detection of hepatocellular carcinoma.
Anand S Mehta, Daryl T-Y Lau, Mengjun Wang, Aysha Aslam, Bilal Nasir, Timothy M Block

PLoS One· February 2019

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Immediate impact of healthcare-facility-onset Clostridium difficile laboratory-identified events reporting methodology change on standardized infection ratios.
Carlos E Figueroa Castro, Louis Palen, Carrie Johnson, Mary Beth Graham, David Letzer, Timothy Block

Infect Control Hosp Epidemiol· December 2018

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Host functions used by hepatitis B virus to complete its life cycle: Implications for developing host-targeting agents to treat chronic hepatitis B.
Bidisha Mitra, Roshan J Thapa, Haitao Guo, Timothy M Block

Antiviral Res· October 2018

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Correction: Application of the Doylestown algorithm for the early detection of hepatocellular carcinoma.
Anand S Mehta, Daryl T-Y Lau, Mengjun Wang, Aysha Aslam, Bilal Nasir, Timothy M Block

PLoS One· October 2018

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Disease Pathways and Mechanisms of Potential Drug Targets.
Marc G Ghany, Timothy M Block

Clin Liver Dis (Hoboken)· July 2018

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