Publications by authors named "Timothy Chlon"

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Scaffolding-dependent CASP1 constrains excessive cell-intrinsic inflammatory signaling in leukemia.
Emma E Uible, Issac Choi, Courtnee A Clough, Aishlin Hassan, Annabelle J Anandappa, Timothy M Chlon

Cell Chem Biol· January 2026

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Prevalence of cytopenia(s) and somatic variants in patients with DDX41 mutant germline predisposition syndrome.
Yael Kusne, Talha Badar, Terra Lasho, Ludovica Marando, Abhishek A Mangaonkar, Timothy Chlon

Br J Haematol· April 2025

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Germline DDX41 mutations in myeloid neoplasms: the current clinical and molecular understanding.
Junichiro Kida, Timothy M Chlon

Curr Opin Hematol· March 2025

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Absence of PNH-clones in DDX41mutant-GPS aids in their distinction from acquired BM failure syndromes.
Yael Kusne, Talha Badar, Terra Lasho, Alejandro Ferrer, Abhishek A Mangaonkar, Timothy Chlon

Leuk Res· October 2024

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DDX41 haploinsufficiency causes inefficient hematopoiesis under stress and cooperates with p53 mutations to cause hematologic malignancy.
Emily Stepanchick, Andrew Wilson, Analise M Sulentic, Kwangmin Choi, Kathleen Hueneman, Timothy M Chlon

Leukemia· August 2024

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Clinical and molecular correlates of somatic and germline variants in patients and families with myeloid neoplasms.
Talha Badar, Ahmad Nanaa, James M Foran, David Viswanatha, Aref Al-Kali, Timothy Chlon

Haematologica· November 2023

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Germline DDX41 mutant predisposition syndromes: Slow driver states to hematological malignancies.
Timothy M Chlon, Mrinal M Patnaik

Am J Hematol· November 2023

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Germline and Somatic Defects in DDX41 and its Impact on Myeloid Neoplasms.
Talha Badar, Timothy Chlon

Curr Hematol Malig Rep· October 2022

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Germline DDX41 mutations cause ineffective hematopoiesis and myelodysplasia.
Timothy M Chlon, Emily Stepanchick, Courtney E Hershberger, Noah J Daniels, Kathleen M Hueneman

Cell Stem Cell· November 2021

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Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.
Sonya Ruiz-Torres, Marion G Brusadelli, David P Witte, Kathryn A Wikenheiser-Brokamp, Sharon Sauter, Timothy M Chlon

Cell Stem Cell· March 2021

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Chronic immune response dysregulation in MDS pathogenesis.
Laura Barreyro, Timothy M Chlon, Daniel T Starczynowski

Blood· October 2018

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Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage.
Timothy M Chlon, Sonya Ruiz-Torres, Logan Maag, Christopher N Mayhew, Kathryn A Wikenheiser-Brokamp

Stem Cell Reports· January 2016

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Global transcriptome and chromatin occupancy analysis reveal the short isoform of GATA1 is deficient for erythroid specification and gene expression.
Timothy M Chlon, Maureen McNulty, Benjamin Goldenson, Alexander Rosinski, John D Crispino

Haematologica· May 2015

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High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells.
Timothy M Chlon, Elizabeth E Hoskins, Christopher N Mayhew, Kathryn A Wikenheiser-Brokamp, Stella M Davies

J Virol· October 2014

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Perturbation of fetal hematopoiesis in a mouse model of Down syndrome's transient myeloproliferative disorder.
Yehudit Birger, Liat Goldberg, Timothy M Chlon, Benjamin Goldenson, Inna Muler

Blood· August 2013

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Ikaros inhibits megakaryopoiesis through functional interaction with GATA-1 and NOTCH signaling.
Sébastien Malinge, Clarisse Thiollier, Timothy M Chlon, Louis C Doré, Lauren Diebold

Blood· March 2013

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Combinatorial regulation of tissue specification by GATA and FOG factors.
Timothy M Chlon, John D Crispino

Development· November 2012

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Cofactor-mediated restriction of GATA-1 chromatin occupancy coordinates lineage-specific gene expression.
Timothy M Chlon, Louis C Doré, John D Crispino

Mol Cell· August 2012

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Chromatin occupancy analysis reveals genome-wide GATA factor switching during hematopoiesis.
Louis C Doré, Timothy M Chlon, Christopher D Brown, Kevin P White, John D Crispino

Blood· April 2012

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Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
Sébastien Malinge, Meghan Bliss-Moreau, Gina Kirsammer, Lauren Diebold, Timothy Chlon

J Clin Invest· March 2012

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HeyL regulates the number of TrkC neurons in dorsal root ganglia.
Abhishek Mukhopadhyay, Jennifer Jarrett, Timothy Chlon, John A Kessler

Dev Biol· October 2009

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Retinoids modulate expression of the endocytic partners megalin, cubilin, and disabled-2 and uptake of vitamin D-binding protein in human mammary cells.
Timothy M Chlon, David A Taffany, Joellen Welsh, Matthew J Rowling

J Nutr· July 2008

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Reduction in PU.1 activity results in a block to B-cell development, abnormal myeloid proliferation, and neonatal lethality.
Isaac B Houston, Meghana B Kamath, Brock L Schweitzer, Timothy M Chlon, Rodney P DeKoter

Exp Hematol· July 2007

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Microarray reveals complement components are regulated in the serum-deprived rat retinal ganglion cell line.
Abdelnaby Khalyfa, Timothy Chlon, He Qiang, Neeraj Agarwal, Nigel G F Cooper

Mol Vis· February 2007

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