Publications by authors named "Timothy Stammers"

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Immunotherapy for the First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer.
Pablo Martinez, Solange Peters, Timothy Stammers, Jean-Charles Soria

Clin Cancer Res· May 2019

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Aza follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 1: Mitigating the genotoxic liability of an aniline metabolite.
Pierre L Beaulieu, Gordon Bolger, Martin Duplessis, Alexandre Gagnon, Michel Garneau, Timothy Stammers

Bioorg Med Chem Lett· March 2015

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Multi-parameter optimization of aza-follow-ups to BI 207524, a thumb pocket 1 HCV NS5B polymerase inhibitor. Part 2: Impact of lipophilicity on promiscuity and in vivo toxicity.
Pierre L Beaulieu, Gordon Bolger, Dan Deon, Martin Duplessis, Gulrez Fazal, Timothy Stammers

Bioorg Med Chem Lett· March 2015

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A prodrug strategy for the oral delivery of a poorly soluble HCV NS5B thumb pocket 1 polymerase inhibitor using self-emulsifying drug delivery systems (SEDDS).
Pierre L Beaulieu, Josie De Marte, Michel Garneau, Laibin Luo, Timothy Stammers

Bioorg Med Chem Lett· January 2015

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Discovery of BI 207524, an indole diamide NS5B thumb pocket 1 inhibitor with improved potency for the potential treatment of chronic hepatitis C virus infection.
Pierre L Beaulieu, Paul C Anderson, Richard Bethell, Michael Bös, Yves Bousquet, Timothy Stammers

J Med Chem· December 2014

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Molecular dynamics simulations and structure-based rational design lead to allosteric HCV NS5B polymerase thumb pocket 2 inhibitor with picomolar cellular replicon potency.
Oliver Hucke, René Coulombe, Pierre Bonneau, Mégan Bertrand-Laperle, Christian Brochu, Timothy A Stammers

J Med Chem· March 2014

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Enantiomeric atropisomers inhibit HCV polymerase and/or HIV matrix: characterizing hindered bond rotations and target selectivity.
Steven R LaPlante, Pat Forgione, Colette Boucher, René Coulombe, James Gillard, Timothy Stammers

J Med Chem· March 2014

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Conformation-based restrictions and scaffold replacements in the design of hepatitis C virus polymerase inhibitors: discovery of deleobuvir (BI 207127).
Steven R LaPlante, Michael Bös, Christian Brochu, Catherine Chabot, René Coulombe, Timothy Stammers

J Med Chem· March 2014

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Anthranilic acid-based Thumb Pocket 2 HCV NS5B polymerase inhibitors with sub-micromolar potency in the cell-based replicon assay.
Timothy A Stammers, René Coulombe, Martin Duplessis, Gulrez Fazal, Alexandre Gagnon

Bioorg Med Chem Lett· December 2013

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Structure-based design of novel HCV NS5B thumb pocket 2 allosteric inhibitors with submicromolar gt1 replicon potency: discovery of a quinazolinone chemotype.
Pierre L Beaulieu, René Coulombe, Jianmin Duan, Gulrez Fazal, Cédrickx Godbout, Timothy A Stammers

Bioorg Med Chem Lett· July 2013

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Discovery of a novel series of non-nucleoside thumb pocket 2 HCV NS5B polymerase inhibitors.
Timothy A Stammers, René Coulombe, Jean Rancourt, Bounkham Thavonekham, Gulrez Fazal

Bioorg Med Chem Lett· May 2013

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Indole 5-carboxamide Thumb Pocket I inhibitors of HCV NS5B polymerase with nanomolar potency in cell-based subgenomic replicons (part 2): central amino acid linker and right-hand-side SAR studies.
Pierre L Beaulieu, Catherine Chabot, Jianmin Duan, Michel Garneau, James Gillard, Timothy A Stammers

Bioorg Med Chem Lett· June 2011

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N-Acetamideindolecarboxylic acid allosteric 'finger-loop' inhibitors of the hepatitis C virus NS5B polymerase: discovery and initial optimization studies.
Pierre L Beaulieu, Eric Jolicoeur, James Gillard, Christian Brochu, René Coulombe, Timothy Stammers

Bioorg Med Chem Lett· February 2010

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Improved replicon cellular activity of non-nucleoside allosteric inhibitors of HCV NS5B polymerase: from benzimidazole to indole scaffolds.
Pierre L Beaulieu, James Gillard, Darren Bykowski, Christian Brochu, Nathalie Dansereau, Timothy Stammers

Bioorg Med Chem Lett· October 2006

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