Publications by authors named "Toby Ferguson"

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Neurofilament Proteoforms in Amyotrophic Lateral Sclerosis Are Different in Cerebrospinal Fluid and Blood.
John B Coulton, Yingxin He, Melissa M Budelier, Nicolas Barthélemy, Margaret D Ireland, Toby Ferguson

Ann Neurol· December 2025

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Central Nervous System Biodistribution and Pharmacokinetics of Radiolabeled Tofersen in Rodents, Nonhuman Primates, and Humans.
Brendon E Cook, Donald G McLaren, Jenna M Sullivan, Georges El Fakhri, Daniel L Yokell, Toby A Ferguson

J Nucl Med· November 2025

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Serious Neurologic Adverse Events in Tofersen Clinical Trials for Amyotrophic Lateral Sclerosis.
Alexandra Lovett, Sowmya Chary, Suma Babu, Gaëlle Bruneteau, Jonathan D Glass, Toby A Ferguson

Muscle Nerve· June 2025

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Safety, tolerability, and pharmacokinetics of antisense oligonucleotide BIIB078 in adults with C9orf72-associated amyotrophic lateral sclerosis: a phase 1, randomised, double blinded, placebo-controlled, multiple ascending dose study.
Leonard H van den Berg, Jeffrey D Rothstein, Pamela J Shaw, Suma Babu, Michael Benatar, Toby A Ferguson

Lancet Neurol· September 2024

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A pediatric quantitative systems pharmacology model of neurofilament trafficking in spinal muscular atrophy treated with the antisense oligonucleotide nusinersen.
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Toby Ferguson

CPT Pharmacometrics Syst Pharmacol· February 2023

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Increased Risk of Venous Thromboembolism in Patients With Amyotrophic Lateral Sclerosis: Results From a US Insurance Claims Database Study.
Varant Kupelian, Emma Viscidi, Susan Hall, Li Li, Susan Eaton, Toby Ferguson

Neurol Clin Pract· February 2023

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Trial of Antisense Oligonucleotide Tofersen for ALS.
Timothy M Miller, Merit E Cudkowicz, Angela Genge, Pamela J Shaw, Gen Sobue, Toby A Ferguson

N Engl J Med· September 2022

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Correction to: Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
Michael Benatar, Joanne Wuu, Peter M Andersen, Robert C Bucelli, Jinsy A Andrews, Toby Ferguson

Neurotherapeutics· September 2022

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Design of a Randomized, Placebo-Controlled, Phase 3 Trial of Tofersen Initiated in Clinically Presymptomatic SOD1 Variant Carriers: the ATLAS Study.
Michael Benatar, Joanne Wuu, Peter M Andersen, Robert C Bucelli, Jinsy A Andrews, Toby Ferguson

Neurotherapeutics· July 2022

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An age-dependent mathematical model of neurofilament trafficking in healthy conditions.
Alessio Paris, Pranami Bora, Silvia Parolo, Michael Monine, Xiao Tong, Toby Ferguson

CPT Pharmacometrics Syst Pharmacol· April 2022

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Gold Coast diagnostic criteria: Implications for ALS diagnosis and clinical trial enrollment.
Steve Vucic, Toby A Ferguson, Catherine Cummings, Michael T Hotchkin, Angela Genge

Muscle Nerve· November 2021

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A binary hidden Markov model on spatial network for amyotrophic lateral sclerosis disease spreading pattern analysis.
Yei Eun Shin, Dawei Liu, Huiyan Sang, Toby A Ferguson, Peter X K Song

Stat Med· June 2021

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Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for ALS.
Timothy Miller, Merit Cudkowicz, Pamela J Shaw, Peter M Andersen, Nazem Atassi, Toby A Ferguson

N Engl J Med· July 2020

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Autologistic network model on binary data for disease progression study.
Yei Eun Shin, Huiyan Sang, Dawei Liu, Toby A Ferguson, Peter X K Song

Biometrics· December 2019

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Critical design considerations for time-to-event endpoints in amyotrophic lateral sclerosis clinical trials.
Ruben P A van Eijk, Stavros Nikolakopoulos, Kit C B Roes, Bas M Middelkoop, Toby A Ferguson

J Neurol Neurosurg Psychiatry· December 2019

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Prospective natural history study of ALS clinical characteristics and biomarkers.
Alexander J Cammack, Nazem Atassi, Theodore Hyman, Leonard H van den Berg, Matthew Harms, Toby Ferguson

Neurology· October 2019

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Acute Effects of Riluzole and Retigabine on Axonal Excitability in Patients With Amyotrophic Lateral Sclerosis: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.
Maria O Kovalchuk, Jules A A C Heuberger, Boudewijn T H M Sleutjes, Dimitrios Ziagkos, Leonard H van den Berg, Toby A Ferguson

Clin Pharmacol Ther· December 2018

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Implementing Motor Unit Number Index (MUNIX) in a large clinical trial: Real world experience from 27 centres.
Christoph Neuwirth, Nathalie Braun, Kristl G Claeys, Robert Bucelli, Christina Fournier, Toby Ferguson

Clin Neurophysiol· August 2018

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Increasing the efficiency of clinical trials in neurodegenerative disorders using group sequential trial designs.
Ruben P A van Eijk, Stavros Nikolakopoulos, Toby A Ferguson, Dawei Liu, Marinus J C Eijkemans

J Clin Epidemiol· June 2018

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Monitoring disease progression with plasma creatinine in amyotrophic lateral sclerosis clinical trials.
Ruben P A van Eijk, Marinus J C Eijkemans, Toby A Ferguson, Stavros Nikolakopoulos, Jan H Veldink

J Neurol Neurosurg Psychiatry· February 2018

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Quantitative strength testing in ALS clinical trials.
Jeremy M Shefner, Dawei Liu, Melanie L Leitner, David Schoenfeld, Donald R Johns, Toby Ferguson

Neurology· August 2016

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Rescue of Glaucomatous Neurodegeneration by Differentially Modulating Neuronal Endoplasmic Reticulum Stress Molecules.
Liu Yang, Shaohua Li, Linqing Miao, Haoliang Huang, Feisi Liang, Toby A Ferguson

J Neurosci· May 2016

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Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling.
Sabrina M Holland, Kaitlin M Collura, Andrea Ketschek, Kentaro Noma, Toby A Ferguson

Proc Natl Acad Sci U S A· January 2016

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Association of a Novel ACTA1 Mutation With a Dominant Progressive Scapuloperoneal Myopathy in an Extended Family.
Kristen Zukosky, Katherine Meilleur, Bryan J Traynor, Jahannaz Dastgir, Livija Medne, Toby A Ferguson

JAMA Neurol· June 2015

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Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration.
Marek Ma, Toby A Ferguson, Kathleen M Schoch, Jian Li, Yaping Qian

Neurobiol Dis· August 2013

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