Publications by authors named "Todd Black"

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Contribution of telacebec to novel drug regimens in a murine tuberculosis model.
Oliver D Komm, Sandeep Tyagi, Andrew Garcia, Deepak Almeida, Yong Chang, Todd Black

Antimicrob Agents Chemother· January 2025

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Cerastecins inhibit membrane lipooligosaccharide transport in drug-resistant Acinetobacter baumannii.
Hao Wang, Andrii Ishchenko, Jason Skudlarek, Pamela Shen, Liudmila Dzhekieva, Todd A Black

Nat Microbiol· May 2024

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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration.
Shuzhi Dong, Zhiqiang Zhao, Haiqun Tang, Guoqing Li, Jianping Pan, Todd Black

J Med Chem· March 2024

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Rapid Evolution of a Fragment-like Molecule to Pan-Metallo-Beta-Lactamase Inhibitors: Initial Leads toward Clinical Candidates.
Mihirbaran Mandal, Li Xiao, Weidong Pan, Giovanna Scapin, Guoqing Li, Todd Black

J Med Chem· December 2022

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The pipeline of new molecules and regimens against drug-resistant tuberculosis.
Todd A Black, Ulrike K Buchwald

J Clin Tuberc Other Mycobact Dis· December 2021

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Are outer-membrane targets the solution for MDR Gram-negative bacteria?
Scott S Walker, Todd A Black

Drug Discov Today· September 2021

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A small-molecule inhibitor of BamA impervious to efflux and the outer membrane permeability barrier.
Elizabeth M Hart, Angela M Mitchell, Anna Konovalova, Marcin Grabowicz, Jessica Sheng, Todd A Black

Proc Natl Acad Sci U S A· October 2019

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Interim analysis of a 3-year follow-up study of NS5A and NS3 resistance-associated substitutions after treatment with grazoprevir-containing regimens in participants with chronic HCV infection.
Frederick Lahser, Angela Galloway, Peggy Hwang, John Palcza, Joann Brunhofer, Todd Black

Antivir Ther· September 2019

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Inhibitor of intramembrane protease RseP blocks the σ response causing lethal accumulation of unfolded outer membrane proteins.
Anna Konovalova, Marcin Grabowicz, Carl J Balibar, Juliana C Malinverni, Ronald E Painter, Todd A Black

Proc Natl Acad Sci U S A· July 2018

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Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.
Scott S Walker, Marc Labroli, Ronald E Painter, Judyann Wiltsie, Brad Sherborne, Todd A Black

PLoS One· September 2017

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Disease Progression and Resolution in Rodent Models of Clostridium difficile Infection and Impact of Antitoxin Antibodies and Vancomycin.
Peter Warn, Pia Thommes, Abdul Sattar, David Corbett, Amy Flattery, Todd Black

Antimicrob Agents Chemother· November 2016

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The Combination of Grazoprevir, a Hepatitis C Virus (HCV) NS3/4A Protease Inhibitor, and Elbasvir, an HCV NS5A Inhibitor, Demonstrates a High Genetic Barrier to Resistance in HCV Genotype 1a Replicons.
Frederick C Lahser, Karin Bystol, Stephanie Curry, Patricia McMonagle, Ellen Xia, Todd Black

Antimicrob Agents Chemother· May 2016

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Hydroxy tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of RHS moiety (Part-3).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan, Todd Black

Bioorg Med Chem Lett· June 2015

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Tricyclic 1,5-naphthyridinone oxabicyclooctane-linked novel bacterial topoisomerase inhibitors as broad-spectrum antibacterial agents-SAR of left-hand-side moiety (Part-2).
Sheo B Singh, David E Kaelin, Jin Wu, Lynn Miesel, Christopher M Tan, Todd Black

Bioorg Med Chem Lett· May 2015

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Murgocil is a highly bioactive staphylococcal-specific inhibitor of the peptidoglycan glycosyltransferase enzyme MurG.
Paul A Mann, Anna Müller, Li Xiao, Pedro M Pereira, Christine Yang, Todd Black

ACS Chem Biol· November 2013

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Discovery of wall teichoic acid inhibitors as potential anti-MRSA β-lactam combination agents.
Hao Wang, Charles J Gill, Sang H Lee, Paul Mann, Paul Zuck, Todd Black

Chem Biol· February 2013

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Detection of HIV-1 CXCR4 tropism and resistance in treatment experienced subjects receiving CCR5 antagonist-Vicriviroc.
Paul McNicholas, Regis A Vilchez, Wayne Greaves, Sushma Kumar, Chinyere Onyebuchi, Todd Black

J Clin Virol· October 2012

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The optimization of pyridazinone series of glucan synthase inhibitors.
Rongze Kuang, Heping Wu, Pauline C Ting, Robert G Aslanian, Jianhua Cao, Todd A Black

Bioorg Med Chem Lett· August 2012

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Lead optimization of a sulfonylurea-based piperazine pyridazinone series of glucan synthase inhibitors.
Andrew J Zych, Sang Q Lam, David M Jenkins, R Jason Herr, Pauline C Ting, Todd A Black

Bioorg Med Chem Lett· July 2012

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Discovery of a novel class of orally active antifungal beta-1,3-D-glucan synthase inhibitors.
Scott S Walker, Yiming Xu, Ilias Triantafyllou, Michelle F Waldman, Cara Mendrick, Todd A Black

Antimicrob Agents Chemother· November 2011

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SAR studies of pyridazinone derivatives as novel glucan synthase inhibitors.
Gang Zhou, Pauline C Ting, Robert Aslanian, Jianhua Cao, David W Kim, Todd A Black

Bioorg Med Chem Lett· May 2011

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Mapping and characterization of vicriviroc resistance mutations from HIV-1 isolated from treatment-experienced subjects enrolled in a phase II study (VICTOR-E1).
Paul M McNicholas, Paul A Mann, Lisa Wojcik, Ping Qiu, Erin Lee, Todd A Black

J Acquir Immune Defic Syndr· March 2011

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The synthesis and structure-activity relationship of pyridazinones as glucan synthase inhibitors.
Pauline C Ting, Rongze Kuang, Heping Wu, Robert G Aslanian, Jianhua Cao, Todd A Black

Bioorg Med Chem Lett· March 2011

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Design and synthesis of potent Gram-negative specific LpxC inhibitors.
U Faruk Mansoor, Dilrukshi Vitharana, Panduranga Adulla Reddy, Dayna L Daubaras, Paul McNicholas, Todd Black

Bioorg Med Chem Lett· February 2011

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Characterization of emergent HIV resistance in treatment-naive subjects enrolled in a vicriviroc phase 2 trial.
Paul McNicholas, Yi Wei, Jeannette Whitcomb, Wayne Greaves, Todd A Black

J Infect Dis· May 2010

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