Publications by authors named "Tony Morales"

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Preclinical characterization of pirtobrutinib, a highly selective, noncovalent (reversible) BTK inhibitor.
Eliana B Gomez, Kevin Ebata, Hetal S Randeria, Mary S Rosendahl, E Peder Cedervall, Tony H Morales

Blood· July 2023

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A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Alexander Drilon, Ramamoorthy Nagasubramanian, James F Blake, Nora Ku, Brian B Tuch, Tony H Morales

Cancer Discov· September 2017

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Structure of the BRAF-MEK complex reveals a kinase activity independent role for BRAF in MAPK signaling.
Jacob R Haling, Jawahar Sudhamsu, Ivana Yen, Steve Sideris, Wendy Sandoval, Tony Morales

Cancer Cell· September 2014

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An ATP-site on-off switch that restricts phosphatase accessibility of Akt.
Kui Lin, Jie Lin, Wen-I Wu, Joshua Ballard, Brian B Lee, Tony H Morales

Sci Signal· May 2012

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Non-oxime pyrazole based inhibitors of B-Raf kinase.
Bradley J Newhouse, Joshua D Hansen, Jonas Grina, Mike Welch, George Topalov, Tony Morales

Bioorg Med Chem Lett· June 2011

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Discovery and SAR of spirochromane Akt inhibitors.
Nicholas C Kallan, Keith L Spencer, James F Blake, Rui Xu, Justin Heizer, Tony H Morales

Bioorg Med Chem Lett· April 2011

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Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
Rui Xu, Anna Banka, James F Blake, Ian S Mitchell, Eli M Wallace, Tony H Morales

Bioorg Med Chem Lett· April 2011

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The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Alex J Buckmelter, Li Ren, Ellen R Laird, Bryson Rast, Greg Miknis, Tony Morales

Bioorg Med Chem Lett· February 2011

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Non-oxime inhibitors of B-Raf(V600E) kinase.
Li Ren, Steve Wenglowsky, Greg Miknis, Bryson Rast, Alex J Buckmelter, Tony Morales

Bioorg Med Chem Lett· February 2011

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Discovery of pyrrolopyrimidine inhibitors of Akt.
James F Blake, Nicholas C Kallan, Dengming Xiao, Rui Xu, Josef R Bencsik, Tony H Morales

Bioorg Med Chem Lett· October 2010

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Georgia Hatzivassiliou, Kyung Song, Ivana Yen, Barbara J Brandhuber, Daniel J Anderson, Tony Morales

Nature· March 2010

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Potent and selective pyrazole-based inhibitors of B-Raf kinase.
Joshua D Hansen, Jonas Grina, Brad Newhouse, Mike Welch, George Topalov, Tony Morales

Bioorg Med Chem Lett· August 2008

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Transient and stable transfection of Chinese hamster ovary cells with the recombinant feline erythropoietin gene and expression, purification, and biological activity of feline erythropoietin protein.
Susan L Baldwin, Tim D Powell, Ramani S Wonderling, Katherine C L Keiser, Tony Morales

Am J Vet Res· December 2003

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Expression and characterization of recombinant canine IL-13 receptor alpha2 protein and its biological activity in vitro.
Liang Tang, Tony Morales, Karen L Boroughs, Kathy Cailles Lo-Keiser, Karen Sellins

Mol Immunol· January 2003

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Cloning, expression, purification, and biological activity of five feline type I interferons.
Ramani Wonderling, Tim Powell, Susan Baldwin, Tony Morales, Scott Snyder

Vet Immunol Immunopathol· October 2002

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