Publications by authors named "Tyler Grebe"

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Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.
Anthony J Metrano, Lucas A Morrill, Gayathri Bommakanti, Robert Casella, Steve Cook, Tyler Grebe

RSC Med Chem· May 2025

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Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.
Jason D Shields, David Baker, Amber Y S Balazs, Gayathri Bommakanti, Robert Casella, Tyler Grebe

J Med Chem· February 2025

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Discovery of (2,4)-4-(()-2-Amino-3-methylbutanamido)-2-(4-boronobutyl)pyrrolidine-2-carboxylic Acid (AZD0011), an Actively Transported Prodrug of a Potent Arginase Inhibitor to Treat Cancer.
Scott N Mlynarski, Brian M Aquila, Susan Cantin, Steve Cook, Aatman Doshi, Tyler Grebe

J Med Chem· December 2024

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Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists.
James S Scott, Darren Stead, Bernard Barlaam, Jason Breed, Rodrigo J Carbajo, Tyler Grebe

J Med Chem· February 2023

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Discovery of AZD9833, a Potent and Orally Bioavailable Selective Estrogen Receptor Degrader and Antagonist.
James S Scott, Thomas A Moss, Amber Balazs, Bernard Barlaam, Jason Breed, Tyler Grebe

J Med Chem· December 2020

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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies.
Bernard Barlaam, Robert Casella, Justin Cidado, Calum Cook, Chris De Savi, Tyler Grebe

J Med Chem· December 2020

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Photoredox Catalysis: 1,4-Conjugate Addition of -Methyl Radicals to Electron-Deficient Olefins via Decarboxylation of -Substituted Acetic Acids.
Lakshmaiah Gingipalli, Jeffrey Boerth, David Emmons, Tyler Grebe, Holia Hatoum-Mokdad

Org Lett· May 2020

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Selective inhibitors of bacterial t-RNA-(N(1)G37) methyltransferase (TrmD) that demonstrate novel ordering of the lid domain.
Pamela J Hill, Ayome Abibi, Robert Albert, Beth Andrews, Moriah M Gagnon, Tyler Grebe

J Med Chem· September 2013

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Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity.
Folkert Reck, Richard Alm, Patrick Brassil, Joseph Newman, Boudewijn Dejonge, Tyler Grebe

J Med Chem· November 2011

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(4R)-3-Allenyl-4-(diphenylmethyl)oxazolidin-2-one, an unsubstituted allenamide.
Michael R Tracey, Tyler P Grebe, William W Brennessel, Richard P Hsung

Acta Crystallogr C· November 2004

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The first successful base-promoted isomerization of propargyl amides to chiral ynamides. Applications in ring-closing metathesis of ene-ynamides and tandem RCM of diene-ynamides.
Jian Huang, Hui Xiong, Richard P Hsung, C Rameshkumar, Jason A Mulder, Tyler P Grebe

Org Lett· July 2002

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