Publications by authors named "Ulrich Hommel"

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Ligandability Assessment of IL-1β by Integrated Hit Identification Approaches.
Anna Vulpetti, Jean-Michel Rondeau, Marie-Hélène Bellance, Jutta Blank, Ralf Boesch, Ulrich Hommel

J Med Chem· May 2024

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Discovery of a selective and biologically active low-molecular weight antagonist of human interleukin-1β.
Ulrich Hommel, Konstanze Hurth, Jean-Michel Rondeau, Anna Vulpetti, Daniela Ostermeier

Nat Commun· September 2023

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Discovery of Potent Small-Molecule Inhibitors of WDR5-MYC Interaction.
Jian Ding, Guo Li, Hejun Liu, Lulu Liu, Ying Lin, Ulrich Hommel

ACS Chem Biol· January 2023

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Comprehensive and High-Throughput Exploration of Chemical Space Using Broadband F NMR-Based Screening.
Andreas Lingel, Anna Vulpetti, Tony Reinsperger, Andrew Proudfoot, Regis Denay, Ulrich Hommel

Angew Chem Int Ed Engl· August 2020

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Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
Edwige Lorthiois, Karen Anderson, Anna Vulpetti, Olivier Rogel, Frederic Cumin, Ulrich Hommel

J Med Chem· July 2017

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Structure-Based Library Design and Fragment Screening for the Identification of Reversible Complement Factor D Protease Inhibitors.
Anna Vulpetti, Stefan Randl, Simon Rüdisser, Nils Ostermann, Paul Erbel, Ulrich Hommel

J Med Chem· March 2017

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Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.
Henrik Möbitz, Rainer Machauer, Philipp Holzer, Andrea Vaupel, Frédéric Stauffer, Ulrich Hommel

ACS Med Chem Lett· March 2017

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Small-molecule factor D inhibitors targeting the alternative complement pathway.
Jürgen Maibaum, Sha-Mei Liao, Anna Vulpetti, Nils Ostermann, Stefan Randl, Ulrich Hommel

Nat Chem Biol· December 2016

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A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space.
Sai Chetan K Sukuru, Florian Nigsch, Jean Quancard, Martin Renatus, Rajiv Chopra, Ulrich Hommel

Protein Sci· November 2010

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Design and NMR-based screening of LEF, a library of chemical fragments with different local environment of fluorine.
Anna Vulpetti, Ulrich Hommel, Gregory Landrum, Richard Lewis, Claudio Dalvit

J Am Chem Soc· September 2009

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Direct methods and residue type specific isotope labeling in NMR structure determination and model-driven sequential assignment.
Andreas Schedlbauer, Renate Auer, Karin Ledolter, Martin Tollinger, Karin Kloiber, Ulrich Hommel

J Biomol NMR· October 2008

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"Virtual fragment linking": an approach to identify potent binders from low affinity fragment hits.
Thomas J Crisman, Andreas Bender, Mariusz Milik, Jeremy L Jenkins, Josef Scheiber, Ulrich Hommel

J Med Chem· April 2008

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Automated backbone and side-chain assignment of mitochondrial matrix cyclophilin D.
Andreas Schedlbauer, Bernd Hoffmann, Georg Kontaxis, Simon Rüdisser, Ulrich Hommel

J Biomol NMR· July 2007

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Backbone 1H, 13C, and 15N resonance assignments for the 26-kD human de-ubiquitinating enzyme UCH-L3.
Richard Harris, Ulf Eidhoff, Daniela Vinzenz, Martin Renatus, Bernd Gerhartz, Ulrich Hommel

Biomol NMR Assign· July 2007

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Aspartic proteases in drug discovery.
Jörg Eder, Ulrich Hommel, Frederic Cumin, Bruno Martoglio, Bernd Gerhartz

Curr Pharm Des· March 2007

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Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Paul Erbel, Nikolaus Schiering, Allan D'Arcy, Martin Renatus, Markus Kroemer, Ulrich Hommel

Nat Struct Mol Biol· April 2006

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Crystal structure of human BACE2 in complex with a hydroxyethylamine transition-state inhibitor.
Nils Ostermann, Jörg Eder, Ulf Eidhoff, Florence Zink, Ulrich Hassiepen, Ulrich Hommel

J Mol Biol· January 2006

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1,4-Diazepane-2,5-diones as novel inhibitors of LFA-1.
Sompong Wattanasin, Joerg Kallen, Stewart Myers, Qin Guo, Michael Sabio, Ulrich Hommel

Bioorg Med Chem Lett· February 2005

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Structure and allosteric regulation of the alpha X beta 2 integrin I domain.
Thomas Vorup-Jensen, Christian Ostermeier, Motomu Shimaoka, Ulrich Hommel, Timothy A Springer

Proc Natl Acad Sci U S A· February 2003

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1,4-Diazepane-2-ones as novel inhibitors of LFA-1.
Sompong Wattanasin, Rainer Albert, Claus Ehrhardt, Didier Roche, Michael Sabio, Ulrich Hommel

Bioorg Med Chem Lett· February 2003

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Small molecule inhibitors induce conformational changes in the I domain and the I-like domain of lymphocyte function-associated antigen-1. Molecular insights into integrin inhibition.
Karl Welzenbach, Ulrich Hommel, Gabriele Weitz-Schmidt

J Biol Chem· March 2002

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