Publications by authors named "Val S Goodfellow"

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Mixed lineage kinase 3 mediates release of C-X-C motif ligand 10-bearing chemotactic extracellular vesicles from lipotoxic hepatocytes.
Samar H Ibrahim, Petra Hirsova, Kyoko Tomita, Steven F Bronk, Nathan W Werneburg, Val S Goodfellow

Hepatology· March 2016

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The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.
Gang Zhang, Dongwei Guo, Prasanta K Dash, Mariluz Araínga, Jayme L Wiederin, Val S Goodfellow

Nanomedicine· January 2016

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Discovery, synthesis, and characterization of an orally bioavailable, brain penetrant inhibitor of mixed lineage kinase 3.
Val S Goodfellow, Colin J Loweth, Satheesh B Ravula, Torsten Wiemann, Thong Nguyen

J Med Chem· October 2013

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The new small-molecule mixed-lineage kinase 3 inhibitor URMC-099 is neuroprotective and anti-inflammatory in models of human immunodeficiency virus-associated neurocognitive disorders.
Daniel F Marker, Marie-Ève Tremblay, Jenna M Puccini, Justin Barbieri, Mary A Gantz Marker, Val S Goodfellow

J Neurosci· June 2013

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Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
Mingzhu Zhang, Junko Tamiya, Linh Nguyen, Martin W Rowbottom, Brian Dyck, Val S Goodfellow

Bioorg Med Chem Lett· May 2007

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Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Martin W Rowbottom, Troy D Vickers, Junko Tamiya, Mingzhu Zhang, Brian Dyck, Val S Goodfellow

Bioorg Med Chem Lett· April 2007

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Manipulation of small-molecule inhibitory kinetics modulates MCH-R1 function.
David A Schwarz, Molly M Allen, Robert E Petroski, Jordan E Pomeroy, Christopher E Heise, Val S Goodfellow

Mol Cell Endocrinol· October 2006

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Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.
Martin W Rowbottom, Troy D Vickers, Brian Dyck, Jonathan Grey, Junko Tamiya, Val S Goodfellow

Bioorg Med Chem Lett· September 2006

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Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.
Sarah Hudson, Mehrak Kiankarimi, Martin W Rowbottom, Troy D Vickers, Dongpei Wu, Val S Goodfellow

Bioorg Med Chem Lett· September 2006

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Substituted chromones and quinolones as potent melanin-concentrating hormone receptor 1 antagonists.
Brian Dyck, Liren Zhao, Junko Tamiya, Joseph Pontillo, Sarah Hudson, Val S Goodfellow

Bioorg Med Chem Lett· August 2006

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A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties.
Brian Dyck, Stacy Markison, Liren Zhao, Junko Tamiya, Jonathan Grey, Val S Goodfellow

J Med Chem· June 2006

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Potent and orally active non-peptide antagonists of the human melanocortin-4 receptor based on a series of trans-2-disubstituted cyclohexylpiperazines.
Fabio C Tucci, Nicole S White, Stacy Markison, Margaret Joppa, Joe A Tran, Val S Goodfellow

Bioorg Med Chem Lett· October 2005

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1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists.
Charles Q Huang, Tracy Baker, David Schwarz, Jun Fan, Christopher E Heise, Val S Goodfellow

Bioorg Med Chem Lett· August 2005

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Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Martin W Rowbottom, Troy D Vickers, Brian Dyck, Junko Tamiya, Mingzhu Zhang, Val S Goodfellow

Bioorg Med Chem Lett· July 2005

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Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists.
Jonathan Grey, Brian Dyck, Martin W Rowbottom, Junko Tamiya, Troy D Vickers, Val S Goodfellow

Bioorg Med Chem Lett· February 2005

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Potent imidazole and triazole CB1 receptor antagonists related to SR141716.
Brian Dyck, Val S Goodfellow, Teresa Phillips, Jonathan Grey, Mustapha Haddach

Bioorg Med Chem Lett· March 2004

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Assessment of a small molecule melanocortin-4 receptor-specific agonist on energy homeostasis.
David Cepoi, Teresa Phillips, Mary Cismowski, Val S Goodfellow, Nick Ling

Brain Res· March 2004

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Body weight regulation by selective MC4 receptor agonists and antagonists.
Alam C Foster, Margaret Joppa, Stacy Markison, Kathy R Gogas, Beth A Fleck, Val S Goodfellow

Ann N Y Acad Sci· June 2003

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The melanocortin system and its role in obesity and cachexia.
Val S Goodfellow, John Saunders

Curr Top Med Chem· May 2003

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