Publications by authors named "Victor Segarra"

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Integrating multiple lines of evidence to assess freshwater ecosystem health in a tropical river basin.
Juseth E Chancay, Oscar Lucas-Solis, Daniela Alvear-S, Dayana Martínez-R, Gisella Mena, Víctor Segarra

Environ Pollut· November 2021

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The effects of the Nordic hamstring exercise on sprint performance and eccentric knee flexor strength: A systematic review and meta-analysis of intervention studies among team sport players.
Iker J Bautista, Juan Vicente-Mampel, Luis Baraja-Vegas, Víctor Segarra, Fernando Martín

J Sci Med Sport· September 2021

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Atomistic simulations shed new light on the activation mechanisms of RORγ and classify it as Type III nuclear hormone receptor regarding ligand-binding paths.
Suwipa Saen-Oon, Estrella Lozoya, Victor Segarra, Victor Guallar, Robert Soliva

Sci Rep· November 2019

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4-Amino-7,8-dihydro-1,6-naphthyridin-5(6 H)-ones as Inhaled Phosphodiesterase Type 4 (PDE4) Inhibitors: Structural Biology and Structure-Activity Relationships.
Richard S Roberts, Sara Sevilla, Manel Ferrer, Joan Taltavull, Begoña Hernández, Victor Segarra

J Med Chem· March 2018

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Application of a phenotypic drug discovery strategy to identify biological and chemical starting points for inhibition of TSLP production in lung epithelial cells.
Adelina Orellana, Vicente García-González, Rosa López, Sonia Pascual-Guiral, Estrella Lozoya, Victor Segarra

PLoS One· January 2018

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Confirmatory factor analysis of VISA-P scale and measurement invariance across sexes in athletes with patellar tendinopathy.
Sergio Hernandez-Sanchez, Ferran Abat, María D Hidalgo, Antonio I Cuesta-Vargas, Victor Segarra

J Sport Health Sci· September 2017

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Biphenyl Pyridazinone Derivatives as Inhaled PDE4 Inhibitors: Structural Biology and Structure-Activity Relationships.
Jordi Gràcia, Maria Antonia Buil, Jordi Castro, Peter Eichhorn, Manel Ferrer, Victor Segarra

J Med Chem· December 2016

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Setup and validation of shake-flask procedures for the determination of partition coefficients (logD) from low drug amounts.
Axel Andrés, Martí Rosés, Clara Ràfols, Elisabeth Bosch, Sonia Espinosa, Víctor Segarra

Eur J Pharm Sci· August 2015

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl amides as potent and long acting muscarinic antagonists.
Maria Prat, María Antonia Buil, Maria Dolors Fernández, Laia Tort, Juan Manuel Monleón, Victor Segarra

Bioorg Med Chem Lett· April 2015

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Microwave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.
Ana I Sánchez, Ricardo Meneses, José M Mínguez, Araceli Núñez, Rafael R Castillo, Víctor Segarra

Org Biomol Chem· June 2014

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Synthesis and evaluation of quinazoline derivatives as phosphodiesterase 7 inhibitors.
Ana I Sánchez, Valentín Martínez-Barrasa, Carolina Burgos, Juan J Vaquero, Julio Alvarez-Builla, Víctor Segarra

Bioorg Med Chem· April 2013

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Discovery of a novel class of zwitterionic, potent, selective and orally active S1P₁ direct agonists.
Nuria Aguilar, Marta Mir, Pedro M Grima, Manel López, Victor Segarra

Bioorg Med Chem Lett· December 2012

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1,7-Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase.
Wenceslao Lumeras, Laura Vidal, Bernat Vidal, Cristina Balagué, Adelina Orellana, Víctor Segarra

J Med Chem· November 2011

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Maria Prat, María Antonia Buil, Maria Dolors Fernández, Jordi Castro, Juan Manuel Monleón, Victor Segarra

Bioorg Med Chem Lett· June 2011

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
María Prat, Dolors Fernández, M Antonia Buil, María I Crespo, Gaspar Casals, Victor Segarra

J Med Chem· August 2009

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1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.
Franco Fernández, Olga Caamaño, M Isabel Nieto, Carmen López, Xerardo García-Mera, Victor Segarra

Bioorg Med Chem· May 2009

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1-, 3- and 8-substituted-9-deazaxanthines as potent and selective antagonists at the human A2B adenosine receptor.
Angela Stefanachi, Jose Manuel Brea, Maria Isabel Cadavid, Nuria B Centeno, Cristina Esteve, Victor Segarra

Bioorg Med Chem· March 2008

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Synthesis, adenosine receptor binding and 3D-QSAR of 4-substituted 2-(2'-furyl)-1,2,4-triazolo[1,5-a]quinoxalines.
Ana Martínez, Hugo Gutiérrez-de-Terán, José Brea, Enrique Raviña, Maria Isabel Loza, Victor Segarra

Bioorg Med Chem· February 2008

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Design, synthesis, and structure-activity relationships of 1-,3-,8-, and 9-substituted-9-deazaxanthines at the human A2B adenosine receptor.
Angelo Carotti, Maria Isabel Cadavid, Nuria B Centeno, Cristina Esteve, Maria Isabel Loza, Victor Segarra

J Med Chem· January 2006

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Combinatorial approaches towards the discovery of new tryptase inhibitors.
Montserrat del Fresno, Dolors Fernández-Forner, Montserrat Miralpeix, Victor Segarra, Hamish Ryder

Bioorg Med Chem Lett· March 2005

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Design, synthesis and biological activity of a targeted library of potential tryptase inhibitors.
Mónica García, Xavier del Rio, Sandra Silvestre, Mario Rubiralta, Estrella Lozoya, Victor Segarra

Org Biomol Chem· June 2004

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Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents.
Vittorio Dal Piaz, Maria Carla Castellana, Claudia Vergelli, Maria Paola Giovannoni, Amadeu Gavaldà, Victor Segarra

J Enzyme Inhib Med Chem· August 2002

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