Publications by authors named "Hamish Ryder"

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Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.
Niall Igoe, Elliott D Bayle, Oleg Fedorov, Cynthia Tallant, Pavel Savitsky, Hamish Ryder

J Med Chem· January 2017

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Discovery of potent inhibitors of the lysophospholipase autotaxin.
Pritom Shah, Anne Cheasty, Caroline Foxton, Tony Raynham, Muddasar Farooq, Hamish Ryder

Bioorg Med Chem Lett· November 2016

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Pharmacological characterization of abediterol, a novel inhaled β(2)-adrenoceptor agonist with long duration of action and a favorable safety profile in preclinical models.
Mònica Aparici, Mireia Gómez-Angelats, Dolors Vilella, Raquel Otal, Carla Carcasona, Hamish Ryder

J Pharmacol Exp Ther· August 2012

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Synthesis and biological activity of pyrido[3',2':4,5]furo[3,2-d]pyrimidine derivatives as novel and potent phosphodiesterase type 4 inhibitors.
Joan Taltavull, Jordi Serrat, Jordi Gràcia, Amadeu Gavaldà, Mònica Córdoba, Hamish Ryder

Eur J Med Chem· October 2011

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists.
Maria Prat, María Antonia Buil, Maria Dolors Fernández, Jordi Castro, Juan Manuel Monleón, Hamish Ryder

Bioorg Med Chem Lett· June 2011

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Synthesis and biological activity of pyrido[3',2':4,5]thieno[3,2-d]pyrimidines as phosphodiesterase type 4 inhibitors.
Joan Taltavull, Jordi Serrat, Jordi Gràcia, Amadeu Gavaldà, Míriam Andrés, Hamish Ryder

J Med Chem· October 2010

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Characterization of aclidinium bromide, a novel inhaled muscarinic antagonist, with long duration of action and a favorable pharmacological profile.
Amadeu Gavaldà, Montserrat Miralpeix, Israel Ramos, Raquel Otal, Cristina Carreño, Hamish Ryder

J Pharmacol Exp Ther· November 2009

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Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinol esters as potent and long-acting muscarinic antagonists with potential for minimal systemic exposure after inhaled administration: identification of (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(3-phenoxypropyl)-1-azoniabicyclo[2.2.2]octane bromide (aclidinium bromide).
María Prat, Dolors Fernández, M Antonia Buil, María I Crespo, Gaspar Casals, Hamish Ryder

J Med Chem· August 2009

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Discovery and characterization of 4'-(2-furyl)-N-pyridin-3-yl-4,5'-bipyrimidin-2'-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist.
Bernat Vidal, Arsenio Nueda, Cristina Esteve, Teresa Domenech, Sonia Benito, Hamish Ryder

J Med Chem· May 2007

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New pyrrolopyrimidin-6-yl benzenesulfonamides: potent A2B adenosine receptor antagonists.
Cristina Esteve, Arsenio Nueda, José Luis Díaz, Jorge Beleta, Alvaro Cárdenas, Hamish Ryder

Bioorg Med Chem Lett· July 2006

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Combinatorial approaches towards the discovery of new tryptase inhibitors.
Montserrat del Fresno, Dolors Fernández-Forner, Montserrat Miralpeix, Victor Segarra, Hamish Ryder

Bioorg Med Chem Lett· March 2005

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Synthesis and structure-activity relationships of piperidinylpyrrolopyridine derivatives as potent and selective H1 antagonists.
Silvia Fonquerna, Montse Miralpeix, Lluís Pagès, Carles Puig, Arantxa Cardús, Hamish Ryder

Bioorg Med Chem Lett· February 2005

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Synthesis and structure-activity relationships of novel histamine H1 antagonists: indolylpiperidinyl benzoic acid derivatives.
Silvia Fonquerna, Montse Miralpeix, Lluís Pagès, Carles Puig, Arantxa Cardús, Hamish Ryder

J Med Chem· December 2004

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Synthesis and biological evaluation of 2-phenylpyran-4-ones: a new class of orally active cyclooxygenase-2 inhibitors.
Francisco Caturla, Juan-Miguel Jiménez, Núria Godessart, Mercè Amat, Alvaro Cárdenas, Hamish Ryder

J Med Chem· July 2004

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Synthesis and evaluation of some pyrazolo[3,4-d]pyridazinones and analogues as PDE 5 inhibitors potentially useful as peripheral vasodilator agents.
Vittorio Dal Piaz, Maria Carla Castellana, Claudia Vergelli, Maria Paola Giovannoni, Amadeu Gavaldà, Hamish Ryder

J Enzyme Inhib Med Chem· August 2002

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Studies on quinazolinones as dual inhibitors of Pgp and MRP1 in multidrug resistance.
Shouming Wang, Hamish Ryder, Ian Pretswell, Paul Depledge, John Milton

Bioorg Med Chem Lett· February 2002

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