Publications by authors named "William Finlay"

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Digitally Enabled AI-Interpreted Salivary Ferning-Based Ovulation Prediction: Feasibility Study.
Elizabeth Peebles, William Finlay, Thao-Mi Nguyen, Samuel Barrett, Prudhvi Thirumalaraju

J Med Internet Res· August 2025

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Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns.
Orla Cunningham, Martin Scott, Zhaohui Sunny Zhou, William J J Finlay

MAbs· April 2022

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affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states .
Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, William Finlay

MAbs· May 2021

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De novo discovery of antibody drugs - great promise demands scrutiny.
William J J Finlay, Alexey A Lugovskoy

MAbs· July 2019

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Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
Lindsay B Avery, Jason Wade, Mengmeng Wang, Amy Tam, Amy King, William J Finlay

MAbs· January 2019

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Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement.
William J J Finlay, James E Coleman, Jonathan S Edwards, Kevin S Johnson

MAbs· January 2019

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Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources.
William J J Finlay, Laird Bloom, Joanne Grant, Edward Franklin, Deirdre Ní Shúilleabháin

Methods Mol Biol· January 2018

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Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens.
William J J Finlay, Laird Bloom, Sreeja Varghese, Bénédicte Autin, Orla Cunningham

Methods Mol Biol· January 2018

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Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Adam R Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, William J J Finlay

Antibodies (Basel)· March 2016

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A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
Chao Tu, Virginie Terraube, Amy Sze Pui Tam, Wayne Stochaj, Brian J Fennell, William J J Finlay

J Biol Chem· January 2016

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Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Sue Townsend, Brian J Fennell, James R Apgar, Matthew Lambert, Barry McDonnell, William J J Finlay

Proc Natl Acad Sci U S A· December 2015

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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
Brian J Fennell, Barry McDonnell, Amy Sze Pui Tam, Lijun Chang, John Steven, William J J Finlay

MAbs· January 2015

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Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential.
Ciara M Mahon, Matthew A Lambert, Jacob Glanville, Jason M Wade, Brian J Fennell, William J J Finlay

J Mol Biol· May 2013

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Molecular scanning: combining random mutagenesis, ribosome display, and bioinformatic analysis for protein engineering.
Alfredo Darmanin-Sheehan, William James Jonathan Finlay, Orla Cunningham, Brian Joseph Fennell

Methods Mol Biol· December 2012

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An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
Heather H Shih, Chao Tu, Wei Cao, Anne Klein, Renee Ramsey, William J J Finlay

J Biol Chem· December 2012

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Natural and man-made V-gene repertoires for antibody discovery.
William J J Finlay, Juan C Almagro

Front Immunol· November 2012

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Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids.
Leeying Wu, Katarzyna Oficjalska, Matthew Lambert, Brian J Fennell, Alfredo Darmanin-Sheehan, William J J Finlay

J Immunol· January 2012

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Synthetic antibodies designed on natural sequence landscapes.
Wenwu Zhai, Jacob Glanville, Markus Fuhrmann, Li Mei, Irene Ni, William J J Finlay

J Mol Biol· September 2011

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Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology.
Tyrone Bowes, Shirley A Hanley, Aaron Liew, Marc Eglon, Kaveh Mashayekhi, William J J Finlay

J Biomol Screen· August 2011

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A high-affinity recombinant antibody permits rapid and sensitive direct detection of myeloperoxidase.
Barry McDonnell, Stephen Hearty, William J J Finlay, Richard O'Kennedy

Anal Biochem· March 2011

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Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources.
William J J Finlay, Laird Bloom, Orla Cunningham

Methods Mol Biol· February 2011

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Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens.
William J J Finlay, Laird Bloom, Orla Cunningham

Methods Mol Biol· February 2011

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Optimisation of 2-cyano-pyrimidine inhibitors of cathepsin K: improving selectivity over hERG.
Zoran Rankovic, Jiaqiang Cai, Jennifer Kerr, Xavier Fradera, John Robinson, William Finlay

Bioorg Med Chem Lett· November 2010

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2-Phenyl-9H-purine-6-carbonitrile derivatives as selective cathepsin S inhibitors.
Jiaqiang Cai, D Jonathan Bennett, Zoran Rankovic, Maureen Dempster, Xavier Fradera, William Finlay

Bioorg Med Chem Lett· August 2010

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Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.
William J Finlay, Orla Cunningham, Matthew A Lambert, Alfredo Darmanin-Sheehan, Xuemei Liu

J Mol Biol· May 2009

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