Publications by authors named "Xandra Breakefield"

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AstroGreen transgenic mouse illuminates the trafficking of astrocyte-derived extracellular vesicles.
Lisa Nieland, Edwina Abou Haidar, David Rufino-Ramos, Shilpa Prabhakar, Youssef Samaha, Xandra O Breakefield

Mol Cell Neurosci· December 2025

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Intratumoral delivery of 4-1BBL boosts IL-12-triggered anti-glioma immunity.
Taral R Lunavat, Lisa Nieland, Sanne M van de Looij, Alexandra J E M de Reus, Charles P Couturier, Xandra O Breakefield

Mol Ther· November 2025

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AAV hamartin gene therapy in a stochastic, cerebral mouse model of tuberous sclerosis type 1.
Edwina Abou Haidar, Shilpa Prabhakar, Alexandra L Geffrey, Mohammed Mahamdeh, Tomeh Tomeh, Xandra O Breakefield

Mol Ther Methods Clin Dev· September 2025

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Intracellular and Extracellular Vesicle miRNA Signatures in Human iPSC-Derived Neural Stem Cells and Floor Plate Progenitors.
Lilian Cruz, Frederico Moraes Ferreira, Camila Miranda Lopes-Ramos, Zhiyun Wei, William T Hendriks, Xandra Owens Breakefield

FASEB J· August 2025

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Engineered AAV capsids mediate transduction of murine neurofibroma and sciatic nerve.
Edwina Abou Haidar, Shilpa Prabhakar, Pike See Cheah, Killian S Hanlon, Paula Espinoza, Xandra O Breakefield

Gene Ther· July 2025

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Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges.
Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield

Nanomedicine (Lond)· June 2025

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Engineering of CD63 Enables Selective Extracellular Vesicle Cargo Loading and Enhanced Payload Delivery.
Wataru Obuchi, Ayrton Zargani-Piccardi, Kevin Leandro, David Rufino-Ramos, Emilio Di Lanni, Xandra O Breakefield

J Extracell Vesicles· June 2025

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Extracellular vesicles for the delivery of gene therapy.
Emilio Di Ianni, Wataru Obuchi, Koen Breyne, Xandra O Breakefield

Nat Rev Bioeng· May 2025

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Glioblastoma Cortical Organoids Recapitulate Cell-State Heterogeneity and Intercellular Transfer.
Vamsi Mangena, Rony Chanoch-Myers, Rafaela Sartore, Bruna Paulsen, Simon Gritsch, Xandra O Breakefield

Cancer Discov· February 2025

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Intratumoral gene delivery of 4-1BBL boosts IL-12-triggered anti-glioblastoma immunity.
Taral R Lunavat, Lisa Nieland, Sanne M van de Looij, Alexandra J E M de Reus, Charles P Couturier, Xandra O Breakefield

bioRxiv· February 2025

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CRISPR targeting of mmu-miR-21a through a single adeno-associated virus vector prolongs survival of glioblastoma-bearing mice.
Lisa Nieland, Anne B Vrijmoet, Isabelle W Jetten, David Rufino-Ramos, Alexandra J E M de Reus, Xandra O Breakefield

Mol Ther· January 2025

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Enhanced mRNA delivery using ultrasound-delivered click reactive anchors.
Emilio Di Ianni, Jueun Jeon, Huiyu Hu, Jeremy M Quintana, Chanseo Lee, Xandra O Breakefield

bioRxiv· January 2025

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Probing the glioma micro-environment: Analysis using biopsy in combination with ultra-fast cyclic immunolabeling.
Thomas S van Solinge, Juhyun Oh, Erik Abels, Peter Koch, Xandra O Breakefield

Neoplasia· November 2024

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Exploring the potential of cell-derived vesicles for transient delivery of gene editing payloads.
Kevin Leandro, David Rufino-Ramos, Koen Breyne, Emilio Di Ianni, Sara M Lopes, Xandra O Breakefield

Adv Drug Deliv Rev· August 2024

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Correction: Real-time imaging of TRAIL-induced apoptosis of glioma tumors in vivo.
Khalid Shah, Yi Tang, Xandra Breakefield, Ralph Weissleder

Oncogene· August 2024

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Erratum: Gene replacement therapy in a schwannoma mouse model of neurofibromatosis type 2.
Shilpa Prabhakar, Roberta L Beauchamp, Pike See Cheah, Akiko Yoshinaga, Edwina Abou Haidar, Xandra O Breakefield

Mol Ther Methods Clin Dev· June 2024

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Probing the glioma micro-environment: analysis using biopsy in combination with ultra-fast cyclic immunolabeling.
Thomas S van Solinge, Juhyun Oh, Erik Abels, Peter Koch, Xandra O Breakefield

bioRxiv· June 2024

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Opportunities and challenges for innovative and equitable healthcare.
David J Ecker, Clarice D Aiello, Joseph R Arron, C Frank Bennett, Amy Bernard, Xandra O Breakefield

Nat Rev Drug Discov· May 2024

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Heparin interferes with the uptake of liposomes in glioma.
Thomas S van Solinge, Kristina Pagh Friis, Killian O'Brien, Romy L Verschoor, Jeroen van Aarle, Xandra O Breakefield

Int J Pharm X· December 2023

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Roles of extracellular vesicles in glioblastoma: foes, friends and informers.
Taral R Lunavat, Lisa Nieland, Anne B Vrijmoet, Ayrton Zargani-Piccardi, Youssef Samaha, Xandra O Breakefield

Front Oncol· November 2023

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Longitudinal analysis of serum-derived extracellular vesicle RNA to monitor dacomitinib treatment response in EGFR-amplified recurrent glioblastoma patients.
Anudeep Yekula, Tiffaney Hsia, Robert R Kitchen, Sudipto K Chakrabortty, Wei Yu, Xandra O Breakefield

Neurooncol Adv· September 2023

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Extracellular communication between brain cells through functional transfer of Cre mRNA mediated by extracellular vesicles.
David Rufino-Ramos, Kevin Leandro, Pedro R L Perdigão, Killian O'Brien, Maria Manuel Pinto, Xandra O Breakefield

Mol Ther· July 2023

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Tracking human neurologic disease status in mouse brain/plasma using reporter-tagged, EV-associated biomarkers.
Katia E Maalouf, Christine A Vaine, Dawn M Frederick, Akiko Yoshinaga, Wataru Obuchi, Xandra O Breakefield

Mol Ther· July 2023

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Engineered EVs designed to target diseases of the CNS.
Lisa Nieland, Shadi Mahjoum, Emily Grandell, Koen Breyne, Xandra O Breakefield

J Control Release· April 2023

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Illuminating cellular and extracellular vesicle-mediated communication via a split-Nanoluc reporter and .
Thomas S van Solinge, Shadi Mahjoum, Stefano Ughetto, Alessandro Sammarco, Marike L D Broekman, Xandra O Breakefield

Cell Rep Methods· February 2023

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