Publications by authors named "Zachary B Mackey"

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Molecular docking to homology models of human and Trypanosoma brucei ERK8 that identified ortholog-specific inhibitors.
Matthew Merski, Zachary B Mackey

PLoS Negl Trop Dis· September 2025

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A phenotypic screen with Trypanosoma brucei for discovering small molecules that target the SLiM-binding pocket of proliferating cell nuclear antigen orthologs.
Marisa Actis, Naoaki Fujii, Zachary B Mackey

Chem Biol Drug Des· January 2024

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CRIg plays an essential role in intravascular clearance of bloodborne parasites by interacting with complement.
Gongguan Liu, Yong Fu, Mohammed Yosri, Yanli Chen, Peng Sun, Zachary B Mackey

Proc Natl Acad Sci U S A· November 2019

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Depletion of the extracellular-signal regulated kinase 8 homolog in Trypanosoma brucei in vivo reduces its virulence in a mouse target validation study.
Haitham Elaadli, Inyoung Kim, Zachary B Mackey

Mol Biochem Parasitol· March 2018

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Discovery and antiparasitic activity of AZ960 as a Trypanosoma brucei ERK8 inhibitor.
Ana L Valenciano, Aaron C Ramsey, Webster L Santos, Zachary B Mackey

Bioorg Med Chem· October 2016

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Extracellular-signal regulated kinase 8 of Trypanosoma brucei uniquely phosphorylates its proliferating cell nuclear antigen homolog and reveals exploitable properties.
Ana L Valenciano, Giselle M Knudsen, Zachary B Mackey

Cell Cycle· October 2016

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Deviating the level of proliferating cell nuclear antigen in Trypanosoma brucei elicits distinct mechanisms for inhibiting proliferation and cell cycle progression.
Ana L Valenciano, Aaron C Ramsey, Zachary B Mackey

Cell Cycle· December 2015

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Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.
Laura M Sanchez, Giselle M Knudsen, Claudia Helbig, Geraldine De Muylder, Samantha M Mascuch, Zachary B Mackey

J Nat Prod· April 2013

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Early invasion of brain parenchyma by African trypanosomes.
Ute Frevert, Alexandru Movila, Olga V Nikolskaia, Jayne Raper, Zachary B Mackey

PLoS One· February 2013

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High-throughput analysis of an RNAi library identifies novel kinase targets in Trypanosoma brucei.
Zachary B Mackey, Kyriacos Koupparis, Mari Nishino, James H McKerrow

Chem Biol Drug Des· September 2011

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Mining a cathepsin inhibitor library for new antiparasitic drug leads.
Kenny K H Ang, Joseline Ratnam, Jiri Gut, Jennifer Legac, Elizabeth Hansell, Zachary B Mackey

PLoS Negl Trop Dis· May 2011

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Crystal Structures of TbCatB and rhodesain, potential chemotherapeutic targets and major cysteine proteases of Trypanosoma brucei.
Iain D Kerr, Peng Wu, Rachael Marion-Tsukamaki, Zachary B Mackey, Linda S Brinen

PLoS Negl Trop Dis· June 2010

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Trypanosoma cruzi CYP51 inhibitor derived from a Mycobacterium tuberculosis screen hit.
Chiung-Kuang Chen, Patricia S Doyle, Liudmila V Yermalitskaya, Zachary B Mackey, Kenny K H Ang

PLoS Negl Trop Dis· March 2010

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Isolation and identification of two novel SDS-resistant secreted chitinases from Aeromonas schubertii.
Chao-Lin Liu, Chia-Rui Shen, Fong-Fu Hsu, Jeen-Kuan Chen, Pei-Tzu Wu, Zachary B Mackey

Biotechnol Prog· April 2009

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Evaluation of cryptolepine and huperzine derivatives as lead compounds towards new agents for the treatment of human African trypanosomiasis.
Awotunde J Oluwafemi, Emmanuel O Okanla, Pelayo Camps, Diego Muñoz-Torrerob, Zachary B Mackey

Nat Prod Commun· February 2009

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A parasite cysteine protease is key to host protein degradation and iron acquisition.
Theresa C O'Brien, Zachary B Mackey, Richard D Fetter, Youngchool Choe, Anthony J O'Donoghue

J Biol Chem· October 2008

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RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model.
Maha-Hamadien Abdulla, Theresa O'Brien, Zachary B Mackey, Mohamed Sajid, Dennis J Grab

PLoS Negl Trop Dis· September 2008

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Drugs targeting parasite lysosomes.
Patricia S Doyle, Mohamed Sajid, Theresa O'Brien, Kelly Dubois, Juan C Engel, Zachary B Mackey

Curr Pharm Des· June 2008

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Discovery of trypanocidal compounds by whole cell HTS of Trypanosoma brucei.
Zachary B Mackey, Arthur M Baca, Jeremy P Mallari, Beth Apsel, Anang Shelat

Chem Biol Drug Des· May 2006

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Utility of CD117 immunoreactivity in differentiating metastatic melanoma from clear cell sarcoma.
Joaquin J Garcia, Miranda J Kramer, Zachary B Mackey, Richard J O'Donnell, Andrew E Horvai

Arch Pathol Lab Med· March 2006

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Antitrypanosomal activity of 5'-deoxy-5'-(iodomethylene)adenosine and related 6-N-cyclopropyladenosine analogues.
Magdalena Rapp, Trisha A Haubrich, Jacques Perrault, Zachary B Mackey, James H McKerrow

J Med Chem· March 2006

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A cathepsin B-like protease is required for host protein degradation in Trypanosoma brucei.
Zachary B Mackey, Theresa C O'Brien, Doron C Greenbaum, Rebecca B Blank, James H McKerrow

J Biol Chem· November 2004

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Physical and functional interaction between DNA ligase IIIalpha and poly(ADP-Ribose) polymerase 1 in DNA single-strand break repair.
John B Leppard, Zhiwan Dong, Zachary B Mackey, Alan E Tomkinson

Mol Cell Biol· August 2003

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An easily dissociated 26 S proteasome catalyzes an essential ubiquitin-mediated protein degradation pathway in Trypanosoma brucei.
Ziyin Li, Chun-Bin Zou, Yi Yao, Martin A Hoyt, Stephen McDonough, Zachary B Mackey

J Biol Chem· May 2002

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