Publications by authors named "Alain Pierre"

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TIPIN depletion leads to apoptosis in breast cancer cells.
Céline Baldeyron, Amélie Brisson, Bruno Tesson, Fariba Némati, Stéphane Koundrioukoff

Mol Oncol· October 2015

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Synthesis, antitumor activity, and mechanism of action of benzo[b]chromeno[6,5-g][1,8]naphthyridin-7-one analogs of acronycine.
Wen Tian, Rodrigue Yougnia, Sabine Depauw, Amélie Lansiaux, Marie-Hélène David-Cordonnier

J Med Chem· December 2014

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Targeting Bcl-2/Bcl-XL induces antitumor activity in uveal melanoma patient-derived xenografts.
Fariba Némati, Catherine de Montrion, Guillaume Lang, Laurence Kraus-Berthier, Guillaume Carita

PLoS One· September 2014

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TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.
Virginie Maire, Céline Baldeyron, Marion Richardson, Bruno Tesson, Anne Vincent-Salomon

PLoS One· December 2013

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S49076 is a novel kinase inhibitor of MET, AXL, and FGFR with strong preclinical activity alone and in association with bevacizumab.
Mike F Burbridge, Céline J Bossard, Carine Saunier, Imre Fejes, Alain Bruno

Mol Cancer Ther· September 2013

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Polo-like kinase 1: a potential therapeutic option in combination with conventional chemotherapy for the management of patients with triple-negative breast cancer.
Virginie Maire, Fariba Némati, Marion Richardson, Anne Vincent-Salomon, Bruno Tesson

Cancer Res· January 2013

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Novel protein scaffolds as emerging therapeutic proteins: from discovery to clinical proof-of-concept.
Thierry Wurch, Alain Pierré, Stéphane Depil

Trends Biotechnol· November 2012

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Characterization of a large panel of patient-derived tumor xenografts representing the clinical heterogeneity of human colorectal cancer.
Sylvia Julien, Ana Merino-Trigo, Ludovic Lacroix, Marc Pocard, Diane Goéré

Clin Cancer Res· October 2012

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Antiproliferative and iron chelating efficiency of the new bis-8-hydroxyquinoline benzylamine chelator S1 in hepatocyte cultures.
Gérard Lescoat, Stéphane Léonce, Alain Pierré, Lucie Gouffier, François Gaboriau

Chem Biol Interact· January 2012

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Characterization of novel checkpoint kinase 1 inhibitors by in vitro assays and in human cancer cells treated with topoisomerase inhibitors.
Gilles Ferry, Aurélie Studeny, Céline Bossard, Philip M Kubara, Denis Zeyer

Life Sci· August 2011

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Synthesis and cytotoxic activity of benzo[a]acronycine and benzo[b]acronycine substituted on the A ring.
Thomas Gaslonde, Fabiola Covello, Laura Velazquez-Alonso, Stéphane Léonce, Alain Pierré

Eur J Med Chem· May 2011

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Synthesis and biological evaluation of novel benzodioxinocarbazoles (BDCZs) as potential anticancer agents.
Nathalie Ayerbe, Sylvain Routier, Isabelle Gillaizeau, Carmen Maiereanu, Daniel-Henry Caignard

Bioorg Med Chem Lett· August 2010

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An unusual DNA binding compound, S23906, induces mitotic catastrophe in cultured human cells.
Nathalie Cahuzac, Aurélie Studény, Kris Marshall, Isabella Versteege, Kate Wetenhall

Cancer Lett· March 2010

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Synthesis and cytotoxic activity of psorospermin and acronycine analogues in the 3-propyloxy-acridin-9(10H)-one and -benzo[b]acridin-125H-one series.
Sabrina Boutefnouchet, Nguyen Tuan Minh, Rana Putrus, Bruno Pfeiffer, Stéphane Léonce

Eur J Med Chem· February 2010

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Influence of the stereoisomeric position of the reactive acetate groups of the benzo[b]acronycine derivative S23906-1 on its DNA alkylation, helix-opening, cytotoxic, and antitumor activities.
Sabine Depauw, Thomas Gaslonde, Stéphane Léonce, Laurence Kraus-Berthier, William Laine

Mol Pharmacol· December 2009

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Radiosensitization by Chir-124, a selective CHK1 inhibitor: effects of p53 and cell cycle checkpoints.
Yungan Tao, Céline Leteur, Ceyao Yang, Ping Zhang, Maria Castedo

Cell Cycle· April 2009

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Synthesis, cytotoxic activity, and DNA binding properties of antitumor cis-1,2-dihydroxy-1,2-dihydrobenzo[b]acronycine cinnamoyl esters.
Quyên Do, Wen Tian, Rodrigue Yougnia, Thomas Gaslonde, Bruno Pfeiffer

Bioorg Med Chem· March 2009

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Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues.
Jean-Gilles Parmentier, Bernard Portevin, Roy M Golsteyn, Alain Pierré, John Hickman

Bioorg Med Chem Lett· February 2009

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Benzopyridooxathiazepine derivatives as novel potent antimitotic agents.
Sebastien Gallet, Nathalie Flouquet, Pascal Carato, Bruno Pfeiffer, Pierre Renard

Bioorg Med Chem· February 2009

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Structure-activity relationships in the acronycine and benzo[b]acronycine series: role of the pyran ring.
Quyên Do, Huong Doan Thi Mai, Thomas Gaslonde, Bruno Pfeiffer, Stéphane Léonce

Eur J Med Chem· December 2008

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Rebeccamycin derivatives as dual DNA-damaging agents and potent checkpoint kinase 1 inhibitors.
Christelle Marminon, Fabrice Anizon, Pascale Moreau, Bruno Pfeiffer, Alain Pierré

Mol Pharmacol· December 2008

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Synthesis, cytotoxic activity, and mechanism of action of furo[2,3-c]acridin-6-one and benzo[b]furo[3,2-h]acridin-6-one analogues of psorospermin and acronycine.
Sabrina Boutefnouchet, Nicolas Gaboriaud-Kolar, Tuan Minh Nguyen, Sabine Depauw, Marie-Hélène David-Cordonnier

J Med Chem· November 2008

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Novel 5-azaindolocarbazoles as cytotoxic agents and Chk1 inhibitors.
Myriam Lefoix, Gérard Coudert, Sylvain Routier, Bruno Pfeiffer, Daniel-Henri Caignard

Bioorg Med Chem· May 2008

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Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters.
Kazutaka Takagi, Thomas S Dexheimer, Christophe Redon, Olivier Sordet, Keli Agama

Mol Cancer Ther· December 2007

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Synthesis and biological activities of isogranulatimide analogues.
Bernadette Hugon, Fabrice Anizon, Christian Bailly, Roy M Golsteyn, Alain Pierré

Bioorg Med Chem· September 2007

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