Publications by authors named "Alan Naylor"

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Low pH, High Stakes: A Narrative Review Exploring the Acid-Sensing GPR65 Pathway as a Novel Approach in Renal Cell Carcinoma.
Michael Grant, Barbara Cipriani, Alastair Corbin, David Miller, Alan Naylor

Cancers (Basel)· December 2025

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Phenotypic screening identifies a trisubstituted imidazo[1,2-a]pyridine series that induces differentiation in multiple AML cell lines.
Laia Josa-Culleré, Sébastien R G Galan, Thomas J Cogswell, Thomas R Jackson, Morgan Jay-Smith, Alan Naylor

Eur J Med Chem· October 2023

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Discovery of {4-[4,9-bis(ethyloxy)-1-oxo-1,3-dihydro-2H-benzo[f]isoindol-2-yl]-2-fluorophenyl}acetic acid (GSK726701A), a novel EP receptor partial agonist for the treatment of pain.
Mark P Healy, Amanda C Allan, Kristin Bailey, Andy Billinton, Iain P Chessell, Alan Naylor

Bioorg Med Chem Lett· June 2018

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and Efficacy of a Novel and Long-Acting Fungicidal Azole, PC1244, on Aspergillus fumigatus Infection.
Thomas Colley, Gurpreet Sehra, Anuradha Chowdhary, Alexandre Alanio, Steven L Kelly, Alan Naylor

Antimicrob Agents Chemother· May 2018

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Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.
Amanda C Allan, Andy Billinton, Susan H Brown, Anita Chowdhury, Andrew J Eatherton, Alan Naylor

Bioorg Med Chem Lett· July 2011

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Alan Naylor

Bioorg Med Chem Lett· August 2010

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Piperidine-derived gamma-secretase modulators.
Adrian Hall, Richard L Elliott, Gerard M P Giblin, Ishrut Hussain, James Musgrave, Alan Naylor

Bioorg Med Chem Lett· February 2010

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Discovery of 1-[4-(3-chlorophenylamino)-1-methyl-1H-pyrrolo[3,2-c]pyridin-7-yl]-1-morpholin-4-ylmethanone (GSK554418A), a brain penetrant 5-azaindole CB2 agonist for the treatment of chronic pain.
Gerard M P Giblin, Andrew Billinton, Michael Briggs, Andrew J Brown, Iain P Chessell, Alan Naylor

J Med Chem· October 2009

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Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors.
Martin E Swarbrick, Paul J Beswick, Robert J Gleave, Richard H Green, Sharon Bingham, Alan Naylor

Bioorg Med Chem Lett· August 2009

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Identification and optimisation of a novel series of pyrimidine based cyclooxygenase-2 (COX-2) inhibitors. Utilisation of a biotransformation approach.
Paul J Beswick, Andrew P Blackaby, Chas Bountra, Terry Brown, Kerry Browning, Alan Naylor

Bioorg Med Chem Lett· August 2009

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Alan Naylor

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Alan Naylor

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Alan Naylor

Bioorg Med Chem Lett· July 2009

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Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.
Adrian Hall, Andy Billinton, Susan H Brown, Anita Chowdhury, Nicholas M Clayton, Alan Naylor

Bioorg Med Chem Lett· May 2009

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Pyridine-3-carboxamides as novel CB(2) agonists for analgesia.
William L Mitchell, Gerard M P Giblin, Alan Naylor, Andrew J Eatherton, Brian P Slingsby

Bioorg Med Chem Lett· January 2009

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Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain.
Adrian Hall, Susan H Brown, Christopher Budd, Nicholas M Clayton, Gerard M P Giblin, Alan Naylor

Bioorg Med Chem Lett· January 2009

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Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists.
Adrian Hall, Andy Billinton, Alan K Bristow, Susan H Brown, Anita Chowdhury, Alan Naylor

Bioorg Med Chem Lett· July 2008

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Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Alan Naylor

J Med Chem· June 2008

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Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy.
Adrian Hall, Andy Billinton, Susan H Brown, Nicholas M Clayton, Anita Chowdhury, Alan Naylor

Bioorg Med Chem Lett· June 2008

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Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping.
Adrian Hall, Andy Billinton, Susan H Brown, Anita Chowdhury, Gerard M P Giblin, Alan Naylor

Bioorg Med Chem Lett· April 2008

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The novel cyclooxygenase-2 inhibitor GW637185X protects against l-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity.
Jose A Aguirre, Giuseppina Leo, Raquel Cueto, Beth Andbjer, Alan Naylor

Neuroreport· April 2008

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Novel methylene-linked heterocyclic EP1 receptor antagonists.
Adrian Hall, Rino A Bit, Susan H Brown, Anita Chowdhury, Gerard M P Giblin, Alan Naylor

Bioorg Med Chem Lett· March 2008

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BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Alan Naylor

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Alan Naylor

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Paul Beswick, Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Alan Naylor

Bioorg Med Chem Lett· February 2008

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