Publications by authors named "Alan Northrup"

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Wonsuk Chang, Michael D Altman, Charles A Lesburg, Samanthi A Perera, Jennifer A Piesvaux, Alan B Northrup

J Med Chem· April 2022

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A kinase-cGAS cascade to synthesize a therapeutic STING activator.
John A McIntosh, Zhijian Liu, Brian M Andresen, Nastaran Salehi Marzijarani, Jeffrey C Moore, Alan Northrup

Nature· March 2022

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Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.
Graham F Smith, Michael D Altman, Brian Andresen, James Baker, Jason D Brubaker, Alan Northrup

Bioorg Med Chem Lett· June 2017

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Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.
Pierre Daublain, Kung-I Feng, Michael D Altman, Iain Martin, Suman Mukherjee, Alan B Northrup

Mol Pharm· May 2017

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Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.
Jason D Katz, Andrew Haidle, Kaleen K Childers, Anna A Zabierek, James P Jewell, Alan Northrup

Bioorg Med Chem Lett· January 2017

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MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation.
Andrew M Haidle, Kaleen K Childers, Anna A Zabierek, Jason D Katz, James P Jewell, Alan Northrup

Bioorg Med Chem Lett· January 2017

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Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization.
J Michael Ellis, Michael D Altman, Brandon Cash, Andrew M Haidle, Rachel L Kubiak, Alan B Northrup

ACS Med Chem Lett· December 2016

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Inhibition of spleen tyrosine kinase attenuates IgE-mediated airway contraction and mediator release in human precision cut lung slices.
Cynthia J Koziol-White, Yanlin Jia, Gretchen A Baltus, Philip R Cooper, Dennis M Zaller, Alan B Northrup

Br J Pharmacol· November 2016

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Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.
J Michael Ellis, Michael D Altman, Alan Bass, John W Butcher, Alan J Byford, Alan B Northrup

J Med Chem· February 2015

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The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
Tony Siu, Sathyajith E Kumarasinghe, Michael D Altman, Matthew Katcher, Alan Northrup

Bioorg Med Chem Lett· March 2014

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Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.
Lily Y Moy, Yanlin Jia, Michael Caniga, Gissela Lieber, Malgorzata Gil, Alan Northrup

Am J Respir Cell Mol Biol· December 2013

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Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
Alan B Northrup, Matthew H Katcher, Michael D Altman, Melissa Chenard, Matthew H Daniels

J Med Chem· March 2013

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Identification of direct target engagement biomarkers for kinase-targeted therapeutics.
Cloud P Paweletz, Jannik N Andersen, Roy Pollock, Kumiko Nagashima, Mansuo L Hayashi, Alan Northrup

PLoS One· February 2012

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PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models.
Katharine Ellwood-Yen, Heike Keilhack, Kaiko Kunii, Brian Dolinski, Yamicia Connor, Alan Northrup

Cancer Res· April 2011

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Genetic and pharmacological inhibition of PDK1 in cancer cells: characterization of a selective allosteric kinase inhibitor.
Kumiko Nagashima, Stuart D Shumway, Sriram Sathyanarayanan, Albert H Chen, Brian Dolinski, Alan Northrup

J Biol Chem· February 2011

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Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening.
Ekaterina V Bobkova, Michael J Weber, Zangwei Xu, Yan-Ling Zhang, Joon Jung, Alan Northrup

J Biol Chem· June 2010

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Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.
Dongyu Sun, Joon Jung, Thomas S Rush, Zangwei Xu, Michael J Weber, Alan Northrup

Comb Chem High Throughput Screen· January 2010

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Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.
Zangwei Xu, Kumiko Nagashima, Dongyu Sun, Thomas Rush, Alan Northrup

J Biomol Screen· December 2009

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Total synthesis and structural revision of callipeltoside C.
Joseph Carpenter, Alan B Northrup, deMichael Chung, John J M Wiener, Sung-Gon Kim

Angew Chem Int Ed Engl· May 2008

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A new strategy for the synthesis of benzylic sulfonamides: palladium-catalyzed arylation and sulfonamide metathesis.
Jonathan B Grimm, Matthew H Katcher, David J Witter, Alan B Northrup

J Org Chem· October 2007

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The importance of iminium geometry control in enamine catalysis: identification of a new catalyst architecture for aldehyde-aldehyde couplings.
Ian K Mangion, Alan B Northrup, David W C MacMillan

Angew Chem Int Ed Engl· December 2004

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Two-step synthesis of carbohydrates by selective aldol reactions.
Alan B Northrup, David W C MacMillan

Science· September 2004

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Enantioselective organocatalytic direct aldol reactions of alpha-oxyaldehydes: step one in a two-step synthesis of carbohydrates.
Alan B Northrup, Ian K Mangion, Frank Hettche, David W C MacMillan

Angew Chem Int Ed Engl· April 2004

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The first direct and enantioselective cross-aldol reaction of aldehydes.
Alan B Northrup, David W C MacMillan

J Am Chem Soc· June 2002

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The first general enantioselective catalytic Diels-Alder reaction with simple alpha,beta-unsaturated ketones.
Alan B Northrup, David W C MacMillan

J Am Chem Soc· March 2002

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