Publications by authors named "Alexandre Trifilieff"

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Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).
Neil J Press, Roger J Taylor, Joseph D Fullerton, Pamela Tranter, Clive McCarthy, Alexandre Trifilieff

J Med Chem· September 2015

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Comparing the cardiovascular therapeutic indices of glycopyrronium and tiotropium in an integrated rat pharmacokinetic, pharmacodynamic and safety model.
Alexandre Trifilieff, Brian T Ethell, David A Sykes, Kenny J Watson, Steve Collingwood

Toxicol Appl Pharmacol· August 2015

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The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.
Nicola Arnold, David Beattie, Michelle Bradley, Andrew Brearley, Lyndon Brown, Alexandre Trifilieff

Bioorg Med Chem Lett· September 2014

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The Influence of receptor kinetics on the onset and duration of action and the therapeutic index of NVA237 and tiotropium.
David A Sykes, Mark R Dowling, Juliet Leighton-Davies, Toby C Kent, Lindsay Fawcett, Alexandre Trifilieff

J Pharmacol Exp Ther· November 2012

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An investigation into the structure-activity relationships associated with the systematic modification of the β(2)-adrenoceptor agonist indacaterol.
David Beattie, David Beer, Michelle E Bradley, Ian Bruce, Steven J Charlton, Alexandre Trifilieff

Bioorg Med Chem Lett· October 2012

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Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.
Neil J Press, Roger J Taylor, Joseph D Fullerton, Pamela Tranter, Clive McCarthy, Alexandre Trifilieff

J Med Chem· September 2012

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Sphingosine-1-phosphate-induced airway hyper-reactivity in rodents is mediated by the sphingosine-1-phosphate type 3 receptor.
Alexandre Trifilieff, John R Fozard

J Pharmacol Exp Ther· August 2012

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The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases.
Liz Hardaker, Parmjit Bahra, Benjamin Cochin de Billy, Mark Freeman, Natalia Kupfer, Alexandre Trifilieff

Respir Res· April 2012

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The identification of indacaterol as an ultralong-acting inhaled beta2-adrenoceptor agonist.
François Baur, David Beattie, David Beer, David Bentley, Michelle Bradley, Alexandre Trifilieff

J Med Chem· May 2010

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Essential role of phosphoinositide 3-kinase gamma in eosinophil chemotaxis within acute pulmonary inflammation.
Matthew Thomas, Matthew J Edwards, Elzbieta Sawicka, Nicholas Duggan, Emilio Hirsch, Alexandre Trifilieff

Immunology· March 2009

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Allergen-induced lung inflammation in actively sensitized mice assessed with MR imaging.
François-Xavier Blé, Catherine Cannet, Stefan Zurbruegg, Harry Karmouty-Quintana, Reinhard Bergmann, Alexandre Trifilieff

Radiology· September 2008

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Pharmacological characterization of indacaterol, a novel once daily inhaled 2 adrenoceptor agonist, on small airways in human and rat precision-cut lung slices.
Richard G Sturton, Alexandre Trifilieff, Andrew G Nicholson, Peter J Barnes

J Pharmacol Exp Ther· January 2008

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Lung MRI for experimental drug research.
Nicolau Beckmann, Catherine Cannet, Harry Karmouty-Quintana, Bruno Tigani, Stefan Zurbruegg, Alexandre Trifilieff

Eur J Radiol· December 2007

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Effects of PKF242-484 and PKF241-466, novel dual inhibitors of TNF-alpha converting enzyme and matrix metalloproteinases, in a model of intestinal reperfusion injury in mice.
Danielle G Souza, Flávio Lopes Ferreira, Caio T Fagundes, Flávio A Amaral, Angélica T Vieira, Alexandre Trifilieff

Eur J Pharmacol· September 2007

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Effect of adenosine A2A receptor activation in murine models of respiratory disorders.
Olivier Bonneau, Daniel Wyss, Stephane Ferretti, Clare Blaydon, Christopher S Stevenson, Alexandre Trifilieff

Am J Physiol Lung Cell Mol Physiol· May 2006

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In vitro and in vivo pharmacological characterization of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one (indacaterol), a novel inhaled beta(2) adrenoceptor agonist with a 24-h duration of action.
Cliff Battram, Steven J Charlton, Bernard Cuenoud, Mark R Dowling, Robin A Fairhurst, Alexandre Trifilieff

J Pharmacol Exp Ther· May 2006

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Mast cell involvement in the adenosine mediated airway hyper-reactivity in a murine model of ovalbumin-induced lung inflammation.
Daniel Wyss, Olivier Bonneau, Alexandre Trifilieff

Br J Pharmacol· August 2005

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CGH2466, a combined adenosine receptor antagonist, p38 mitogen-activated protein kinase and phosphodiesterase type 4 inhibitor with potent in vitro and in vivo anti-inflammatory activities.
Alexandre Trifilieff, Thomas H Keller, Neil J Press, Trevor Howe, Peter Gedeck

Br J Pharmacol· April 2005

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Airway inflammation: chemokine-induced neutrophilia and the class I phosphoinositide 3-kinases.
Matthew J Thomas, Alexandra Smith, Denise H Head, Laura Milne, Andrew Nicholls, Alexandre Trifilieff

Eur J Immunol· April 2005

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Gender comparison in a murine model of allergen-driven airway inflammation and the response to budesonide treatment.
Randolph Corteling, Alexandre Trifilieff

BMC Pharmacol· April 2004

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Inhibition of Th1- and Th2-mediated airway inflammation by the sphingosine 1-phosphate receptor agonist FTY720.
Elzbieta Sawicka, Claudia Zuany-Amorim, Corinne Manlius, Alexandre Trifilieff, Volker Brinkmann

J Immunol· December 2003

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Differential DNA synthesis in response to activation of protease-activated receptors on cultured guinea-pig tracheal smooth muscle cells.
Randolph Corteling, Olivier Bonneau, Stephane Ferretti, Mireille Ferretti, Alexandre Trifilieff

Naunyn Schmiedebergs Arch Pharmacol· July 2003

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PPAR-alpha and -gamma but not -delta agonists inhibit airway inflammation in a murine model of asthma: in vitro evidence for an NF-kappaB-independent effect.
Alexandre Trifilieff, Anne Bench, Marcus Hanley, Debbie Bayley, Emma Campbell

Br J Pharmacol· May 2003

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IL-17, produced by lymphocytes and neutrophils, is necessary for lipopolysaccharide-induced airway neutrophilia: IL-15 as a possible trigger.
Stephane Ferretti, Olivier Bonneau, Gerald R Dubois, Carol E Jones, Alexandre Trifilieff

J Immunol· February 2003

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Involvement of CCR3-reactive chemokines in eosinophil survival.
Kazuhiko Shinagawa, Alexandre Trifilieff, Gary P Anderson

Int Arch Allergy Immunol· February 2003

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