Publications by authors named "Allen Sickmier"

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Discovery of ATX968: An Orally Available Allosteric Inhibitor of DHX9.
Matthew H Daniels, Jennifer Castro, Young-Tae Lee, Deepali Gotur, Kevin E Knockenhauer, E Allen Sickmier

J Med Chem· May 2025

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Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3',5'-bisphosphate as a potent enzyme inhibitor.
Gordon J Lockbaum, Maureen M Lynes, Sophie A Shen, Julie Liu, Nicholas Holt, E Allen Sickmier

Commun Biol· April 2025

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A Potent, Selective, Small-Molecule Inhibitor of DHX9 Abrogates Proliferation of Microsatellite Instable Cancers with Deficient Mismatch Repair.
Jennifer Castro, Matthew H Daniels, David Brennan, Brian Johnston, Deepali Gotur, E Allen Sickmier

Cancer Res· February 2025

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Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9.
Deepali Gotur, April Case, Julie Liu, E Allen Sickmier, Nicholas Holt

SLAS Discov· December 2023

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Crystal structures of the DExH-box RNA helicase DHX9.
Young Tae Lee, E Allen Sickmier, Simina Grigoriu, Jennifer Castro, P Ann Boriack-Sjodin

Acta Crystallogr D Struct Biol· November 2023

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Correction: Crystal structures of human procathepsin H.
Yue Hao, Whitney E Purtha, Christa Cortesio, Huan Rui, Yan Gu, E Allen Sickmier

PLoS One· June 2019

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Crystal structures of human procathepsin H.
Yue Hao, Whitney Purtha, Christa Cortesio, Huan Rui, Yan Gu, E Allen Sickmier

PLoS One· January 2019

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Development of 2-aminooxazoline 3-azaxanthene β-amyloid cleaving enzyme (BACE) inhibitors with improved selectivity against Cathepsin D.
Jonathan D Low, Michael D Bartberger, Kui Chen, Yuan Cheng, Mark R Fielden, E Allen Sickmier

Medchemcomm· June 2017

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Structural Basis for Apelin Control of the Human Apelin Receptor.
Yingli Ma, Yang Yue, Yanbin Ma, Qing Zhang, Qingtong Zhou, E Allen Sickmier

Structure· June 2017

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Correction to Fragment-Linking Approach Using F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase.
John B Jordan, Douglas A Whittington, Michael D Bartberger, E Allen Sickmier, Kui Chen

J Med Chem· April 2017

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Facile Modulation of Antibody Fucosylation with Small Molecule Fucostatin Inhibitors and Cocrystal Structure with GDP-Mannose 4,6-Dehydratase.
John G Allen, Mirna Mujacic, Michael J Frohn, Alex J Pickrell, Paul Kodama, E Allen Sickmier

ACS Chem Biol· October 2016

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The Panitumumab EGFR Complex Reveals a Binding Mechanism That Overcomes Cetuximab Induced Resistance.
E Allen Sickmier, Robert J M Kurzeja, Klaus Michelsen, Mukta Vazir, Evelyn Yang

PLoS One· September 2016

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Fragment-Linking Approach Using (19)F NMR Spectroscopy To Obtain Highly Potent and Selective Inhibitors of β-Secretase.
John B Jordan, Douglas A Whittington, Michael D Bartberger, E Allen Sickmier, Kui Chen

J Med Chem· April 2016

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Pharmaceutical Optimization of Peptide Toxins for Ion Channel Targets: Potent, Selective, and Long-Lived Antagonists of Kv1.3.
Justin K Murray, Yi-Xin Qian, Benxian Liu, Robin Elliott, Jennifer Aral, E Allen Sickmier

J Med Chem· September 2015

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Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.
Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall, Allen Sickmier

PLoS One· June 2013

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Polyethylene glycol modified FGF21 engineered to maximize potency and minimize vacuole formation.
Jing Xu, Jeanine Bussiere, Junming Yie, Allen Sickmier, Phil An

Bioconjug Chem· June 2013

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Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.
Matthew M Weiss, Toni Williamson, Safura Babu-Khan, Michael D Bartberger, James Brown, E Allen Sickmier

J Med Chem· November 2012

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Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.
Thomas A Dineen, Matthew M Weiss, Toni Williamson, Paul Acton, Safura Babu-Khan, E Allen Sickmier

J Med Chem· November 2012

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A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.
Matthew R Kaller, Scott S Harried, Brian Albrecht, Patricia Amarante, Safura Babu-Khan, E Allen Sickmier

ACS Med Chem Lett· November 2012

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From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).
Yuan Cheng, Ted C Judd, Michael D Bartberger, James Brown, Kui Chen, E Allen Sickmier

J Med Chem· August 2011

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Alternative conformations at the RNA-binding surface of the N-terminal U2AF(65) RNA recognition motif.
Karen R Thickman, E Allen Sickmier, Clara L Kielkopf

J Mol Biol· February 2007

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Structural basis for polypyrimidine tract recognition by the essential pre-mRNA splicing factor U2AF65.
E Allen Sickmier, Katherine E Frato, Haihong Shen, Shanthi R Paranawithana, Michael R Green

Mol Cell· July 2006

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Crystallization and preliminary X-ray analysis of a U2AF65 variant in complex with a polypyrimidine-tract analogue by use of protein engineering.
E Allen Sickmier, Katherine E Frato, Clara L Kielkopf

Acta Crystallogr Sect F Struct Biol Cryst Commun· May 2006

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X-ray structure of a Rex-family repressor/NADH complex insights into the mechanism of redox sensing.
E Allen Sickmier, Dimitris Brekasis, Shanthi Paranawithana, Jeffrey B Bonanno, Mark S B Paget

Structure· January 2005

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The crystal structure of the UvsW helicase from bacteriophage T4.
E Allen Sickmier, Kenneth N Kreuzer, Stephen W White

Structure· April 2004

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