Publications by authors named "Randy Hecht"

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A Novel Fc-FGF21 With Improved Resistance to Proteolysis, Increased Affinity Toward β-Klotho, and Enhanced Efficacy in Mice and Cynomolgus Monkeys.
Shanaka Stanislaus, Randy Hecht, Junming Yie, Todd Hager, Michael Hall

Endocrinology· May 2017

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Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.
Randy Hecht, Yue-Sheng Li, Jeonghoon Sun, Ed Belouski, Michael Hall

PLoS One· June 2013

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Targeted codon optimization improves translational fidelity for an Fc fusion protein.
Katariina M Hutterer, Zhongqi Zhang, Mark Leo Michaels, Ed Belouski, Robert W Hong, Randy Hecht

Biotechnol Bioeng· November 2012

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A novel anion-exchange resin suitable for both discovery research and clinical manufacturing purposes.
Amir Porat, Dwight Winters, Ling Cai, Steve Smith, Frank Abroson, Randy Hecht

Prep Biochem Biotechnol· October 2012

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Long-acting FGF21 has enhanced efficacy in diet-induced obese mice and in obese rhesus monkeys.
Murielle M Véniant, Renee Komorowski, Ping Chen, Shanaka Stanislaus, Katherine Winters, Randy Hecht

Endocrinology· September 2012

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Understanding the physical interactions in the FGF21/FGFR/β-Klotho complex: structural requirements and implications in FGF21 signaling.
Junming Yie, Wei Wang, Liying Deng, Lei-Ting Tam, Jennitte Stevens, Randy Hecht

Chem Biol Drug Des· April 2012

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The FGFR D3 domain determines receptor selectivity for fibroblast growth factor 21.
Jamila Gupte, Li Yang, Xinle Wu, Jennifer Weiszmann, Randy Hecht

J Mol Biol· May 2011

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FGF19-induced hepatocyte proliferation is mediated through FGFR4 activation.
Xinle Wu, Hongfei Ge, Bryan Lemon, Steven Vonderfecht, Jennifer Weiszmann, Randy Hecht

J Biol Chem· February 2010

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Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.
Jing Xu, Shanaka Stanislaus, Narumol Chinookoswong, Yvonne Y Lau, Todd Hager, Randy Hecht

Am J Physiol Endocrinol Metab· November 2009

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Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice.
Xiaofan Li, Hongfei Ge, Jennifer Weiszmann, Randy Hecht, Yue-sheng Li

FEBS Lett· October 2009

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Fibroblast growth factor 21 reverses hepatic steatosis, increases energy expenditure, and improves insulin sensitivity in diet-induced obese mice.
Jing Xu, David J Lloyd, Clarence Hale, Shanaka Stanislaus, Michelle Chen, Randy Hecht

Diabetes· January 2009

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FGF21 N- and C-termini play different roles in receptor interaction and activation.
Junming Yie, Randy Hecht, Jennifer Patel, Jennitte Stevens, Wei Wang

FEBS Lett· January 2009

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Structural determinants of the ADAM inhibition by TIMP-3: crystal structure of the TACE-N-TIMP-3 complex.
Magdalena Wisniewska, Peter Goettig, Klaus Maskos, Edward Belouski, Dwight Winters, Randy Hecht

J Mol Biol· September 2008

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