Publications by authors named "Ann Barbier"

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The clinical progress of mRNA vaccines and immunotherapies.
Ann J Barbier, Allen Yujie Jiang, Peng Zhang, Richard Wooster, Daniel G Anderson

Nat Biotechnol· June 2022

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Safety and Efficacy of Mitapivat in Pyruvate Kinase Deficiency.
Rachael F Grace, Christian Rose, D Mark Layton, Frédéric Galactéros, Wilma Barcellini, Ann J Barbier

N Engl J Med· September 2019

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Phase 1 Single- and Multiple-Ascending-Dose Randomized Studies of the Safety, Pharmacokinetics, and Pharmacodynamics of AG-348, a First-in-Class Allosteric Activator of Pyruvate Kinase R, in Healthy Volunteers.
Hua Yang, Elizabeth Merica, Yue Chen, Marvin Cohen, Ronald Goldwater, Ann J Barbier

Clin Pharmacol Drug Dev· February 2019

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Patient Voice in Rare Disease Drug Development and Endpoints.
Linda S Deal, Jonathan C Goldsmith, Susan Martin, Ann J Barbier, Steven L Roberds

Ther Innov Regul Sci· March 2017

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A phase 1/2 study of intrathecal heparan-N-sulfatase in patients with mucopolysaccharidosis IIIA.
Simon A Jones, Catherine Breen, Fiona Heap, Stewart Rust, Jessica de Ruijter, Ann J Barbier

Mol Genet Metab· July 2016

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Neurocognitive clinical outcome assessments for inborn errors of metabolism and other rare conditions.
Elsa Shapiro, Jessica Bernstein, Heather R Adams, Ann J Barbier, Teresa Buracchio

Mol Genet Metab· June 2016

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A novel LC-MS/MS assay for heparan sulfate screening in the cerebrospinal fluid of mucopolysaccharidosis IIIA patients.
Hicham Naimy, Kendall D Powell, John R Moriarity, Jiang Wu, Thomas G McCauley, Ann J Barbier

Bioanalysis· February 2016

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A phase I/II study of intrathecal idursulfase-IT in children with severe mucopolysaccharidosis II.
Joseph Muenzer, Christian J Hendriksz, Zheng Fan, Suresh Vijayaraghavan, Victor Perry, Ann J Barbier

Genet Med· January 2016

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Levels of glycosaminoglycans in the cerebrospinal fluid of healthy young adults, surrogate-normal children, and Hunter syndrome patients with and without cognitive impairment.
Christian J Hendriksz, Joseph Muenzer, Adeline Vanderver, Jonathan M Davis, Barbara K Burton, Ann J Barbier

Mol Genet Metab Rep· December 2015

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Novel benzamide-based histamine h3 receptor antagonists: the identification of two candidates for clinical development.
Michael A Letavic, Leah Aluisio, Richard Apodaca, Manoj Bajpai, Ann J Barbier

ACS Med Chem Lett· April 2015

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Immunogenicity of idursulfase and clinical outcomes in very young patients (16 months to 7.5 years) with mucopolysaccharidosis II (Hunter syndrome).
Arian Pano, Ann J Barbier, Bonnie Bielefeld, David A H Whiteman, David A Amato

Orphanet J Rare Dis· April 2015

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Pharmacodynamics, pharmacokinetics, safety, and tolerability of encenicline, a selective α7 nicotinic receptor partial agonist, in single ascending-dose and bioavailability studies.
Ann J Barbier, Martijn Hilhorst, André Van Vliet, Peter Snyder, Michael G Palfreyman

Clin Ther· February 2015

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Heterocyclic replacement of the central phenyl core of diamine-based histamine H3 receptor antagonists.
Devin M Swanson, Chandra R Shah, Brian Lord, Kirsten Morton, Lisa K Dvorak, Ann J Barbier

Eur J Med Chem· November 2009

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In-vitro and in-vivo characterization of JNJ-7925476, a novel triple monoamine uptake inhibitor.
Leah Aluisio, Brian Lord, Ann J Barbier, Ian C Fraser, Sandy J Wilson

Eur J Pharmacol· June 2008

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Lead identification of acetylcholinesterase inhibitors-histamine H3 receptor antagonists from molecular modeling.
Scott D Bembenek, John M Keith, Michael A Letavic, Richard Apodaca, Ann J Barbier

Bioorg Med Chem· March 2008

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Synthesis and biological activity of piperazine and diazepane amides that are histamine H3 antagonists and serotonin reuptake inhibitors.
Kiev S Ly, Michael A Letavic, John M Keith, Jennifer M Miller, Emily M Stocking, Ann J Barbier

Bioorg Med Chem Lett· January 2008

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Pharmacological characterization of JNJ-28583867, a histamine H(3) receptor antagonist and serotonin reuptake inhibitor.
Ann J Barbier, Leah Aluisio, Brian Lord, Ying Qu, Sandy J Wilson

Eur J Pharmacol· December 2007

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Dual serotonin transporter inhibitor/histamine H3 antagonists: development of rigidified H3 pharmacophores.
John M Keith, Ann J Barbier, Sandy J Wilson, Kirstin Miller, Jamin D Boggs

Bioorg Med Chem Lett· October 2007

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Benzylamine histamine H(3) antagonists and serotonin reuptake inhibitors.
Michael A Letavic, Emily M Stocking, Ann J Barbier, Pascal Bonaventure, Jamin D Boggs

Bioorg Med Chem Lett· September 2007

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Pyrrolidino-tetrahydroisoquinolines bearing pendant heterocycles as potent dual H3 antagonist and serotonin transporter inhibitors.
John M Keith, Leslie A Gomez, Ann J Barbier, Sandy J Wilson, Jamin D Boggs

Bioorg Med Chem Lett· August 2007

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Synthesis and biological evaluation of diamine-based histamine H3 antagonists with serotonin reuptake inhibitor activity.
Emily M Stocking, Jennifer M Miller, Ann J Barbier, Sandy J Wilson, Jamin D Boggs

Bioorg Med Chem Lett· June 2007

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Novel naphthyridines are histamine H3 antagonists and serotonin reuptake transporter inhibitors.
Michael A Letavic, John M Keith, Kiev S Ly, Ann J Barbier, Jamin D Boggs

Bioorg Med Chem Lett· May 2007

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Pyrrolidino-tetrahydroisoquinolines as potent dual H3 antagonist and serotonin transporter inhibitors.
John M Keith, Leslie A Gomez, Ronald L Wolin, Ann J Barbier, Sandy J Wilson

Bioorg Med Chem Lett· May 2007

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Dual serotonin transporter/histamine H3 ligands: Optimization of the H3 pharmacophore.
John M Keith, Leslie A Gomez, Michael A Letavic, Kiev S Ly, Jill A Jablonowski, Ann J Barbier

Bioorg Med Chem Lett· February 2007

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Novel tetrahydroisoquinolines are histamine H3 antagonists and serotonin reuptake inhibitors.
Michael A Letavic, John M Keith, Jill A Jablonowski, Emily M Stocking, Leslie A Gomez, Ann J Barbier

Bioorg Med Chem Lett· February 2007

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