Publications by authors named "Barbara Leiting"

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Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.
Gui-Bai Liang, Xiaoxia Qian, Tesfaye Biftu, Suresh Singh, Ying-Duo Gao, Barbara Leiting

Bioorg Med Chem Lett· July 2008

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Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors.
Scott D Edmondson, Lan Wei, Jinyou Xu, Jackie Shang, Shiyao Xu, Barbara Leiting

Bioorg Med Chem Lett· April 2008

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Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines.
Dooseop Kim, Jennifer E Kowalchick, Linda L Brockunier, Emma R Parmee, George J Eiermann, Barbara Leiting

J Med Chem· February 2008

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Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors.
Jennifer E Kowalchick, Barbara Leiting, KellyAnn D Pryor, Frank Marsilio, Joseph K Wu

Bioorg Med Chem Lett· November 2007

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4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV.
David E Kaelin, Abigail L Smenton, George J Eiermann, Huaibing He, Barbara Leiting

Bioorg Med Chem Lett· November 2007

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Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes.
Ping Chen, Charles G Caldwell, Robert J Mathvink, Barbara Leiting, Frank Marsilio

Bioorg Med Chem Lett· November 2007

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Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors.
Jason M Cox, Bart Harper, Anthony Mastracchio, Barbara Leiting, Ranabir Sinha Roy

Bioorg Med Chem Lett· August 2007

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Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate).
Dooseop Kim, Jennifer E Kowalchick, Scott D Edmondson, Anthony Mastracchio, Jinyou Xu, Barbara Leiting

Bioorg Med Chem Lett· June 2007

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4-aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV.
Joseph L Duffy, Brian A Kirk, Liping Wang, George J Eiermann, Huaibing He, Barbara Leiting

Bioorg Med Chem Lett· May 2007

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Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.
Gui-Bai Liang, Xiaoxia Qian, Dennis Feng, Tesfaye Biftu, George Eiermann, Barbara Leiting

Bioorg Med Chem Lett· April 2007

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(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Tesfaye Biftu, Dennis Feng, Xiaoxia Qian, Gui-Bai Liang, Gerard Kieczykowski, Barbara Leiting

Bioorg Med Chem Lett· January 2007

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Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors.
Jinyou Xu, Lan Wei, Robert J Mathvink, Scott D Edmondson, George J Eiermann, Barbara Leiting

Bioorg Med Chem Lett· October 2006

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(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Scott D Edmondson, Anthony Mastracchio, Robert J Mathvink, Jiafang He, Bart Harper, Barbara Leiting

J Med Chem· June 2006

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Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors.
Jinyou Xu, Lan Wei, Robert Mathvink, Scott D Edmondson, Anthony Mastracchio, Barbara Leiting

Bioorg Med Chem Lett· March 2006

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Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.
George R Lankas, Barbara Leiting, Ranabir Sinha Roy, George J Eiermann, Maria G Beconi

Diabetes· October 2005

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Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors.
Scott D Edmondson, Anthony Mastracchio, Joseph L Duffy, George J Eiermann, Huaibing He, Barbara Leiting

Bioorg Med Chem Lett· June 2005

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Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Wallace T Ashton, Rosemary M Sisco, Hong Dong, Kathryn A Lyons, Huaibing He, Barbara Leiting

Bioorg Med Chem Lett· May 2005

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Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors.
Jinyou Xu, Lan Wei, Robert Mathvink, Jiafang He, You-Jung Park, Barbara Leiting

Bioorg Med Chem Lett· May 2005

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Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7).
Marie-Berthe Maes, Anne-Marie Lambeir, Kambiz Gilany, Kristel Senten, Pieter Van der Veken, Barbara Leiting

Biochem J· March 2005

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(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Dooseop Kim, Liping Wang, Maria Beconi, George J Eiermann, Michael H Fisher, Barbara Leiting

J Med Chem· January 2005

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Potent and selective proline derived dipeptidyl peptidase IV inhibitors.
Scott D Edmondson, Anthony Mastracchio, Maria Beconi, Lawrence F Colwell, Bahanu Habulihaz, Barbara Leiting

Bioorg Med Chem Lett· October 2004

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Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors.
Jinyou Xu, Hyun O Ok, Edward J Gonzalez, Lawrence F Colwell, Bahanu Habulihaz, Barbara Leiting

Bioorg Med Chem Lett· September 2004

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Substituted piperazines as novel dipeptidyl peptidase IV inhibitors.
Linda L Brockunier, Jiafang He, Lawrence F Colwell, Bahanu Habulihaz, Huaibing He, Barbara Leiting

Bioorg Med Chem Lett· September 2004

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Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors.
Charles G Caldwell, Ping Chen, Jiafang He, Emma R Parmee, Barbara Leiting

Bioorg Med Chem Lett· March 2004

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Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitors.
Wallace T Ashton, Hong Dong, Rosemary M Sisco, George A Doss, Barbara Leiting

Bioorg Med Chem Lett· February 2004

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