Publications by authors named "Charles Omer"

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STAR-0215 is a Novel, Long-Acting Monoclonal Antibody Inhibitor of Plasma Kallikrein for the Potential Treatment of Hereditary Angioedema.
Vahe Bedian, Nikolaos Biris, Charles Omer, Jou-Ku Chung, James Fuller

J Pharmacol Exp Ther· November 2023

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Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors.
Alexander W Hird, Brian M Aquila, Michael H Block, Edward J Hennessy, Victor M Kamhi, Charles A Omer

Bioorg Med Chem Lett· April 2014

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Discovery of a novel class of dimeric Smac mimetics as potent IAP antagonists resulting in a clinical candidate for the treatment of cancer (AZD5582).
Edward J Hennessy, Ammar Adam, Brian M Aquila, Lillian M Castriotta, Donald Cook, Charles A Omer

J Med Chem· December 2013

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Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.
David A Scott, Les A Dakin, Kevin Daly, David J Del Valle, R Bruce Diebold, Charles A Omer

Bioorg Med Chem Lett· August 2013

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Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.
Melissa M Vasbinder, Brian Aquila, Martin Augustin, Huawei Chen, Tony Cheung, Charles Omer

J Med Chem· March 2013

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Discovery of Disubstituted Imidazo[4,5-b]pyridines and Purines as Potent TrkA Inhibitors.
Tao Wang, Michelle L Lamb, Michael H Block, Audrey Molina Davies, Yongxin Han, Charles A Omer

ACS Med Chem Lett· September 2012

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Discovery of aminopiperidine-based Smac mimetics as IAP antagonists.
Edward J Hennessy, Jamal C Saeh, Li Sha, Terry MacIntyre, Haiyun Wang, Charles A Omer

Bioorg Med Chem Lett· February 2012

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The selective Trk inhibitor AZ623 inhibits brain-derived neurotrophic factor-mediated neuroblastoma cell proliferation and signaling and is synergistic with topotecan.
Peter E Zage, Timothy C Graham, Lizhi Zeng, Wendy Fang, Christine Pien, Charles Omer

Cancer· March 2011

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3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.
David A Scott, Les A Dakin, David J Del Valle, R Bruce Diebold, Lisa Drew, Charles A Omer

Bioorg Med Chem Lett· March 2011

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Identification and preclinical characterization of AZ-23, a novel, selective, and orally bioavailable inhibitor of the Trk kinase pathway.
Kenneth Thress, Terry Macintyre, Haiyun Wang, Dave Whitston, Zhong-Ying Liu, Charles Omer

Mol Cancer Ther· July 2009

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Identification of 3-amido-4-anilinoquinolines as potent and selective inhibitors of CSF-1R kinase.
David A Scott, Carrie L Balliet, Donald J Cook, Audrey M Davies, Thomas W Gero, Charles A Omer

Bioorg Med Chem Lett· February 2009

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3-amido-4-anilinoquinolines as CSF-1R kinase inhibitors 2: Optimization of the PK profile.
David A Scott, Kirsten J Bell, Cheryl T Campbell, Donald J Cook, Les A Dakin, Charles A Omer

Bioorg Med Chem Lett· February 2009

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Pyridyl and thiazolyl bisamide CSF-1R inhibitors for the treatment of cancer.
David A Scott, Brian M Aquila, Geraldine A Bebernitz, Donald J Cook, Les A Dakin, Charles A Omer

Bioorg Med Chem Lett· September 2008

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Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases.
Tao Wang, Michelle L Lamb, David A Scott, Haixia Wang, Michael H Block, Charles A Omer

J Med Chem· August 2008

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4-anilino-5-carboxamido-2-pyridone derivatives as noncompetitive inhibitors of mitogen-activated protein kinase kinase.
Julie A Spicer, Gordon W Rewcastle, Michael D Kaufman, Shannon L Black, Mark S Plummer, Charles Omer

J Med Chem· October 2007

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The effects of a novel MEK inhibitor PD184161 on MEK-ERK signaling and growth in human liver cancer.
Patrick J Klein, C Max Schmidt, Chad A Wiesenauer, Jennifer N Choi, Earl A Gage, Charles Omer

Neoplasia· January 2006

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A role for K-ras in conferring resistance to the MEK inhibitor, CI-1040.
Yuli Wang, Keri Van Becelaere, Ping Jiang, Sally Przybranowski, Charles Omer

Neoplasia· April 2005

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Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition.
Jeffrey F Ohren, Huifen Chen, Alexander Pavlovsky, Christopher Whitehead, Erli Zhang, Charles Omer

Nat Struct Mol Biol· December 2004

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Phase II trial of intravenous CI-1042 in patients with metastatic colorectal cancer.
Oday Hamid, Mary L Varterasian, Scott Wadler, J Randolph Hecht, Al Benson, Charles Omer

J Clin Oncol· April 2003

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