Publications by authors named "Connie Ha"

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Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research.
Jonathan L Golob, Tomiko T Oskotsky, Alice S Tang, Alennie Roldan, Verena Chung, Connie W Y Ha, Rong Chai, Yuci Zhang, Nima Aghaeepour

Cell Rep Med· December 2025

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Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.
Tanya N Weerakkody, Hanna Sabelström, Shan V Andrews, Jean Paul Chadarevian, Marcus Y Chin, Richard Theolis, Connie Ha, Lihong Zhan, Lily Sarrafha, Jonathan Hasselmann, Alina L Chadarevian, Ghazaleh Eskandari-Sedighi, Hayk Davtyan

Sci Transl Med· December 2025

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Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.
Brittany N Flores, Seungyoon B Yu, Isaac V Cohen, Melania H Fanok, Wei Luan, Richard M Tsai, Connie L Ha

Nat Commun· August 2025

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Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques.
Lis de Weerd, Selina Hummel, Stephan A Müller, Iñaki Paris, Thomas Sandmann, Stephan Wagner, Connie Ha, Michael Willem, Stefan F Lichtenthaler, Christian Haass

Mol Neurodegener· August 2025

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Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Nathalie Khoury, Michelle E Pizzo, Claire B Discenza, David Joy, David Tatarakis, Mihail Ivilinov Todorov, Connie Ha, Lily Sarrafha, Darren Chan, Roni Chau, Johann Chow, Yinhan Zhou

Nat Commun· February 2025

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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.
Jing L Guo, Dylan Braun, Gabriel A Fitzgerald, Yun-Ting Hsieh, Lionel Rougé, Suk Ji Han, Connie Ha, Cathal S Mahon, Nathan Nguyen

Cell· January 2025

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VMAP: Vaginal Microbiome Atlas during Pregnancy.
Antonio Parraga-Leo, Tomiko T Oskotsky, Boris Oskotsky, Camilla Wibrand, Alennie Roldan, Connie W Y Ha, Nima Aghaeepour, Jonathan L Golob

JAMIA Open· October 2024

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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Ryan Takahashi, Connie Ha, Patrick C G Haddick, Martin Larhammar

Elife· September 2024

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Urinary and Oral Microbiota Among Men Undergoing Buccal Urethroplasty.
Than S Kyaw, Hiren V Patel, Charles Jones, Connie W Y Ha, Abdur Rahim Khan, Lindsay A Hampson, Nathan M Shaw

Urology· August 2024

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Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew J Simon, Yinhan Zhou, Alfred Chappell, Johann Chow, Connie Ha, Cathal Mahon, Hai Tran

Sci Transl Med· August 2024

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Microbiome preterm birth DREAM challenge: Crowdsourcing machine learning approaches to advance preterm birth research.
Jonathan L Golob, Tomiko T Oskotsky, Alice S Tang, Alennie Roldan, Verena Chung, Connie W Y Ha, Nima Aghaeepour

Cell Rep Med· January 2024

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Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Vaibhav Upadhyay, Rahul K Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, Renuka G Kumar, Connie W Y Ha, Bharath Sreekumar

mBio· August 2023

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DR3 Regulates Intestinal Epithelial Homeostasis and Regeneration After Intestinal Barrier Injury.
Yosuke Shimodaira, Shyam K More, Hussein Hamade, Anna Y Blackwood, Jay P Abraham, Connie W Y Ha, Stephan R Targan

Cell Mol Gastroenterol Hepatol· June 2023

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Microbiome Preterm Birth DREAM Challenge: Crowdsourcing Machine Learning Approaches to Advance Preterm Birth Research.
Jonathan L Golob, Tomiko T Oskotsky, Alice S Tang, Alennie Roldan, Verena Chung, Connie W Y Ha, Nima Aghaeepour

medRxiv· April 2023

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VMAP: Vaginal Microbiome Atlas During Pregnancy.
Antonio Parraga-Leo, Tomiko T Oskotsky, Boris Oskotsky, Camilla Wibrand, Alennie Roldan, Connie W Y Ha, Nima Aghaeepour, Jonathan Golob

medRxiv· April 2023

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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Johannes Gnörich, Connie Ha, Chandler Vieira, Christian Haass

Nat Neurosci· March 2023

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Mild SARS-CoV-2 infection results in long-lasting microbiota instability.
Vaibhav Upadhyay, Rahul Suryawanshi, Preston Tasoff, Maria McCavitt-Malvido, G Renuka Kumar, Connie Ha, Bharat Sreekumar

bioRxiv· December 2022

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The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfaces.
Ivan Vujkovic-Cvijin, Hugh C Welles, Connie W Y Ha, Lutfi Huq, Shreni Mistry

Sci Transl Med· August 2022

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H Suh, Connie Ha, Roni Chau, Shababa T Masoud, Nathalie Khoury, Stephanie Miller, Michael Sasner, Julie A Harris, Johannes Gnörich, Michael Willem, Christian Haass

Mol Neurodegener· June 2022

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Intestinal inflammation alters the antigen-specific immune response to a skin commensal.
Geil R Merana, Laura R Dwyer, Miqdad O Dhariwala, Antonin Weckel, Jeanmarie R Gonzalez, Jungmin Han, Connie W Y Ha, Michael G Kattah, Tiffany C Scharschmidt

Cell Rep· May 2022

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Gestational diabetes: Optimizing Dx and management in primary care.
Connie L Ha, Jay H Shubrook, Tina Mason

J Fam Pract· March 2022

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Author Correction: DART takes aim at community editing.
Connie W Y Ha, Suzanne Devkota

Nat Microbiol· February 2022

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DART takes aim at community editing.
Connie W Y Ha, Suzanne Devkota

Nat Microbiol· January 2022

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Gut microbiota mediate the FGF21 adaptive stress response to chronic dietary protein-restriction in mice.
Anthony Martin, Gertrude Ecklu-Mensah, Connie W Y Ha, Gustaf Hendrick, Donald K Layman

Nat Commun· June 2021

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The new microbiology: cultivating the future of microbiome-directed medicine.
Connie W Y Ha, Suzanne Devkota

Am J Physiol Gastrointest Liver Physiol· December 2020

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