Publications by authors named "Conrad Raab"

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Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
Randy R Miller, Maria Madeira, Harold B Wood, Wayne M Geissler, Conrad E Raab

J Med Chem· November 2020

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Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates.
Stephanie E Barrett, Rob S Burke, Marc T Abrams, Carol Bason, Marina Busuek, Conrad Raab

J Control Release· June 2014

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Quantitation of physiological and biochemical barriers to siRNA liver delivery via lipid nanoparticle platform.
Yan Xu, Mei Ou, Ed Keough, Jeff Roberts, Ken Koeplinger, Conrad Raab

Mol Pharm· May 2014

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Remote electronic control in the regioselective reduction of succinimides: a practical, scalable synthesis of Ep4 antagonist MF-310.
Carmela Molinaro, Danny Gauvreau, Gregory Hughes, Stephen Lau, Sophie Lauzon, Conrad E Raab

J Org Chem· September 2009

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Discovery of N-{N-[(3-cyanophenyl)sulfonyl]-4(R)-cyclobutylamino-(L)-prolyl}-4-[(3',5'-dichloroisonicotinoyl) amino]-(L)-phenylalanine (MK-0668), an extremely potent and orally active antagonist of very late antigen-4.
Linus S Lin, Thomas Lanza, James P Jewell, Ping Liu, Carrie Jones, Conrad Raab

J Med Chem· June 2009

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CYP2C75-involved autoinduction of metabolism in rhesus monkeys of methyl 3-chloro-3'-fluoro-4'-{(1R)-1-[({1-[(trifluoroacetyl)amino]cyclopropyl}carbonyl)amino]ethyl}-1,1'-biphenyl-2-carboxylate (MK-0686), a bradykinin B1 receptor antagonist.
Cuyue Tang, Brian A Carr, Frédéric Poignant, Bennett Ma, Stacey L Polsky-Fisher, Conrad E Raab

J Pharmacol Exp Ther· June 2008

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A novel radioligand for glycine transporter 1: characterization and use in autoradiographic and in vivo brain occupancy studies.
Zhizhen Zeng, Julie A O'Brien, Wei Lemaire, Stacey S O'Malley, Patricia J Miller, Conrad Raab

Nucl Med Biol· April 2008

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A general and efficient 2-amination of pyridines and quinolines.
Jingjun Yin, Bangping Xiang, Mark A Huffman, Conrad E Raab, Ian W Davies

J Org Chem· June 2007

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Synthesis of the first sulfur-35-labeled hERG radioligand.
Conrad E Raab, John W Butcher, Thomas M Connolly, Jerzy Karczewski, Nathan X Yu

Bioorg Med Chem Lett· March 2006

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Identification and characterization of isomeric intermediates in a catalyst formation reaction by means of speciation analysis using HPLC-ICPMS and HPLC-ESI-MS.
Qiang Tu, Tiebang Wang, Christopher J Welch, Peng Wang, Xiujuan Jia, Conrad Raab

Anal Chem· February 2006

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Induction of CYP1A in the beagle dog by an inhibitor of kinase insert domain-containing receptor: differential effects in vitro and in vivo on mRNA and functional activity.
Christopher R Gibson, Charles Lin, Rominder Singh, Cheri M Brown, Karen Richards, Conrad Raab

Drug Metab Dispos· July 2005

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Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.
Dai-Shi Su, M Kristine Markowitz, Kathy L Murphy, Bang-Lin Wan, Matthew M Zrada, Conrad E Raab

Bioorg Med Chem Lett· December 2004

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Pharmacological characterization and radioligand binding properties of a high-affinity, nonpeptide, bradykinin B1 receptor antagonist.
Richard W Ransom, Charles M Harrell, Duane R Reiss, Kathryn L Murphy, Raymond S L Chang, Conrad E Raab

Eur J Pharmacol· September 2004

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Evaluation of ubiquinone concentration and mitochondrial function relative to cerivastatin-induced skeletal myopathy in rats.
William H Schaefer, Jeffery W Lawrence, Amy F Loughlin, Dana A Stoffregen, Lori A Mixson, Conrad E Raab

Toxicol Appl Pharmacol· January 2004

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Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor.
Ping Lu, Michael L Schrag, Donald E Slaughter, Conrad E Raab, Magang Shou

Drug Metab Dispos· November 2003

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Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs.
Maria G Beconi, Ann Mao, David Q Liu, Christopher Kochansky, Tony Pereira, Conrad Raab

Drug Metab Dispos· October 2003

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A small molecule alpha4beta1/alpha4beta7 antagonist differentiates between the low-affinity states of alpha4beta1 and alpha4beta7: characterization of divalent cation dependence.
Linda A Egger, Jin Cao, Christine McCallum, Usha Kidambi, Gail Van Riper, Conrad E Raab

J Pharmacol Exp Ther· September 2003

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Identification of metabolites of a substance P (neurokinin 1 receptor) antagonist in rat hepatocytes and rat plasma.
Cornelis E C A Hop, Yanfeng Wang, Sanjeev Kumar, Maria Victoria Silva Elipe, Conrad E Raab

Drug Metab Dispos· August 2002

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Comparative assessment of the ligand and metal ion binding properties of integrins alpha9beta1 and alpha4beta1.
R Blake Pepinsky, Richard A Mumford, Ling Ling Chen, Diane Leone, Suzanne E Amo, Conrad E Raab

Biochemistry· June 2002

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LC/MS/MS plasma assay for the peptidomimetic VLA4 antagonist I and its major active metabolite II: for treatment of asthma by inhalation.
Alison L Fisher, Elizabeth DePuy, Andrew Jayaraj, Conrad Raab, Matt Braun

J Pharm Biomed Anal· January 2002

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