Publications by authors named "Corinne Reimer"

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Discovery of AZD8421: A Potent CDK2 Inhibitor with Selectivity Against Other CDK Family Members and the Human Kinome.
Avipsa Ghosh, Afshan Ahmed, Konstantina Amoiradaki, Amber Y S Balazs, Bernard Barlaam, Corinne Reimer

J Med Chem· September 2025

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Potent combination benefit of the AKT inhibitor capivasertib and the BCL-2 inhibitor venetoclax in diffuse large B cell lymphoma.
Brandon S Willis, Kevin Mongeon, Hannah Dry, India L Neveras, Nadezda Bryan, Corinne Reimer

Leukemia· December 2024

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A PKPD Case Study: Achieving Clinically Relevant Exposures of AZD5991 in Oncology Mouse Models.
Michael J White, Letitia Cheatham, Shenghua Wen, Graeme Scarfe, Justin Cidado, Corinne Reimer

AAPS J· June 2023

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Design and optimisation of dendrimer-conjugated Bcl-2/x inhibitor, AZD0466, with improved therapeutic index for cancer therapy.
Claire M Patterson, Srividya B Balachander, Iain Grant, Petar Pop-Damkov, Brian Kelly, Corinne Reimer

Commun Biol· January 2021

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Antisense Oligonucleotide Remodels the Suppressive Tumor Microenvironment to Enhance Immune Activation in Combination with Anti-PD-L1.
Theresa A Proia, Maneesh Singh, Richard Woessner, Larissa Carnevalli, Gayathri Bommakanti, Corinne Reimer

Clin Cancer Res· December 2020

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Small molecule AZD4635 inhibitor of AR signaling rescues immune cell function including CD103 dendritic cells enhancing anti-tumor immunity.
Alexandra Borodovsky, Christine M Barbon, Yanjun Wang, Minwei Ye, Laura Prickett, Corinne Reimer

J Immunother Cancer· July 2020

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Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.
Erica Banks, Michael Grondine, Deepa Bhavsar, Evan Barry, Jason G Kettle, Corinne Reimer

Sci Transl Med· April 2020

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Differential Activity of ATR and WEE1 Inhibitors in a Highly Sensitive Subpopulation of DLBCL Linked to Replication Stress.
Lucy A Young, Lenka Oplustil O'Connor, Christelle de Renty, Margaret H Veldman-Jones, Thierry Dorval, Corinne Reimer

Cancer Res· July 2019

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Expression of Concern for Lee et al., "Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression".
Sam W Lee, Corinne L Reimer, Li Fang, M Luisa Iruela-Arispe, Stuart A Aaronson

Mol Cell Biol· May 2019

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Pharmacological Inhibition of PARP6 Triggers Multipolar Spindle Formation and Elicits Therapeutic Effects in Breast Cancer.
Zebin Wang, Shaun E Grosskurth, Tony Cheung, Philip Petteruti, Jingwen Zhang, Corinne Reimer

Cancer Res· December 2018

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BRD4 facilitates replication stress-induced DNA damage response.
Jingwen Zhang, Austin M Dulak, Maureen M Hattersley, Brandon S Willis, Jenni Nikkilä, Corinne Reimer

Oncogene· July 2018

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AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies.
Garrett W Rhyasen, Maureen M Hattersley, Yi Yao, Austin Dulak, Wenxian Wang, Corinne Reimer

Mol Cancer Ther· November 2016

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Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation.
Ryan E Henry, Evan R Barry, Lillian Castriotta, Brendon Ladd, Aleksandra Markovets, Corinne Reimer

Oncotarget· September 2016

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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.
Brendon Ladd, Anne Marie Mazzola, Teeru Bihani, Zhongwu Lai, James Bradford, Corinne Reimer

Oncotarget· August 2016

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Aurora kinase inhibitor nanoparticles target tumors with favorable therapeutic index in vivo.
Susan Ashton, Young Ho Song, Jim Nolan, Elaine Cadogan, Jim Murray, Corinne L Reimer

Sci Transl Med· February 2016

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AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer.
David Hong, Razelle Kurzrock, Youngsoo Kim, Richard Woessner, Anas Younes, Corinne Reimer

Sci Transl Med· November 2015

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The MET Inhibitor AZD6094 (Savolitinib, HMPL-504) Induces Regression in Papillary Renal Cell Carcinoma Patient-Derived Xenograft Models.
Alwin G Schuller, Evan R Barry, Rhys D O Jones, Ryan E Henry, Melanie M Frigault, Corinne Reimer

Clin Cancer Res· June 2015

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Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers.
Teeru Bihani, Scott A Ezell, Brendon Ladd, Shaun E Grosskurth, Anne Marie Mazzola, Corinne Reimer

Oncotarget· February 2015

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Synergistic induction of apoptosis by combination of BTK and dual mTORC1/2 inhibitors in diffuse large B cell lymphoma.
Scott A Ezell, Michele Mayo, Teeru Bihani, Suprawee Tepsuporn, Suping Wang, Corinne Reimer

Oncotarget· July 2014

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Inhibition of platelet-derived growth factor receptor α by MEDI-575 reduces tumor growth and stromal fibroblast content in a model of non-small cell lung cancer.
Naomi Laing, Brenda McDermott, Shenghua Wen, David Yang, Deborah Lawson, Corinne Reimer

Mol Pharmacol· June 2013

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Comparisons of the efficacy of a Jak1/2 inhibitor (AZD1480) with a VEGF signaling inhibitor (cediranib) and sham treatments in mouse tumors using DCE-MRI, DW-MRI, and histology.
Mary E Loveless, Deborah Lawson, Michael Collins, Murali V Prasad Nadella, Corinne Reimer

Neoplasia· January 2012

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A human monoclonal anti-ANG2 antibody leads to broad antitumor activity in combination with VEGF inhibitors and chemotherapy agents in preclinical models.
Jeffrey L Brown, Z Alexander Cao, Maria Pinzon-Ortiz, Jane Kendrew, Corinne Reimer

Mol Cancer Ther· January 2010

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Longitudinally quantitative 2-deoxy-2-[18F]fluoro-D-glucose micro positron emission tomography imaging for efficacy of new anticancer drugs: a case study with bortezomib in prostate cancer murine model.
Yumin Zhang, Melissa Saylor, Shenhua Wen, Matthew D Silva, Mark Rolfe, Corinne Reimer

Mol Imaging Biol· January 2007

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Comparison of biochemical and biological effects of ML858 (salinosporamide A) and bortezomib.
Mark J Williamson, Jonathan L Blank, Frank J Bruzzese, Yueying Cao, J Scott Daniels, Corinne L Reimer

Mol Cancer Ther· December 2006

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Perspectives on molecular and anatomical imaging in drug discovery.
Matthew D Silva, Mac Johnson, Donna Cvet, Rob Robertson, Erik Kupperman, Corinne Reimer

Biotechniques· December 2005

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