Publications by authors named "Danny Shen"

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Classification system proposed to guide the design, development, regulatory approval, and scaling of long acting, small- and macro-molecule parenteral products (CS-BLAP).
Simone Perazzolo, Danny D Shen, Rodney Jy Ho

J Pharm Sci· November 2025

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Physiologically based Pharmacokinetic Model Validated to Enable Predictions Of Multiple Drugs in a Long-acting Drug-combination Nano-Particles (DcNP): Confirmation with 3 HIV Drugs, Lopinavir, Ritonavir, and Tenofovir in DcNP Products.
Simone Perazzolo, Danny D Shen, Ariel M Scott, Rodney J Y Ho

J Pharm Sci· June 2024

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Incorporating Uremic Solute-mediated Inhibition of OAT1/3 Improves PBPK Prediction of Tenofovir Renal and Systemic Disposition in Patients with Severe Kidney Disease.
Shih-Yu Chang, Weize Huang, Alenka Chapron, Antonio J López Quiñones, Joanne Wang, Danny D Shen

Pharm Res· November 2023

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Co-consuming green tea with raloxifene decreases raloxifene systemic exposure in healthy adult participants.
John D Clarke, Sabrina M Judson, Dan-Dan Tian, Trevor O Kirby, Rakshit S Tanna, Danny D Shen

Clin Transl Sci· October 2023

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Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction.
Dennis D Wang, Sophia E Airhart, Bo Zhou, Laura M Shireman, Siyi Jiang, Danny D Shen

JACC Basic Transl Sci· December 2022

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Model-Based Analysis of the Influence of Alcohol Use and Age on Pharmacokinetics-Pharmacodynamics of Oral Oxycodone in Middle-Age and Older Community-Dwelling Adults.
Bojan B Lalovic, Laura Shireman, Danny D Shen, Monique M Cherrier

J Clin Pharmacol· September 2022

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Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 2: Model for the Drug-combination Nanoparticles.
Simone Perazzolo, Danny D Shen, Rodney J Y Ho

J Pharm Sci· March 2022

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Physiologically Based Pharmacokinetic Modeling of 3 HIV Drugs in Combination and the Role of Lymphatic System after Subcutaneous Dosing. Part 1: Model for the Free-Drug Mixture.
Simone Perazzolo, Laura M Shireman, Danny D Shen, Rodney J Y Ho

J Pharm Sci· February 2022

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Elevated customary alcohol consumption attenuates opioid effects.
Monique M Cherrier, Danny D Shen, Laura Shireman, Andrew J Saxon, Tracy Simpson

Pharmacol Biochem Behav· December 2021

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Predicting Maternal-Fetal Disposition of Fentanyl Following Intravenous and Epidural Administration Using Physiologically Based Pharmacokinetic Modeling.
Sara Shum, Danny D Shen, Nina Isoherranen

Drug Metab Dispos· November 2021

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Relationship of Phosphatidylethanol Biomarker to Self-Reported Alcohol Drinking Patterns in Older and Middle-Age Adults.
Monique M Cherrier, Laura M Shireman, Katie Wicklander, Winnie Yeung, Preetma Kooner, Danny Shen

Alcohol Clin Exp Res· December 2020

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Novel Long-Acting Drug Combination Nanoparticles Composed of Gemcitabine and Paclitaxel Enhance Localization of Both Drugs in Metastatic Breast Cancer Nodules.
Jesse Yu, Qingxin Mu, Simone Perazzolo, James I Griffin, Linxi Zhu, Danny D Shen

Pharm Res· September 2020

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LETTER TO THE EDITOR.
Monique Cherrier, Gregory Terman, Danny Shen, Laura Shireman, Andrew Saxon

J Am Osteopath Assoc· July 2020

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Pharmacodynamics of Glyburide, Metformin, and Glyburide/Metformin Combination Therapy in the Treatment of Gestational Diabetes Mellitus.
Diana L Shuster, Laura M Shireman, Xiaosu Ma, Danny D Shen, Shannon K Flood Nichols

Clin Pharmacol Ther· June 2020

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An Improved Vascularized, Dual-Channel Microphysiological System Facilitates Modeling of Proximal Tubular Solute Secretion.
Alenka Chapron, Brian D Chapron, Dale W Hailey, Shih-Yu Chang, Tomoki Imaoka, Danny Shen

ACS Pharmacol Transl Sci· June 2020

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Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101.
Simone Perazzolo, Laura M Shireman, Lisa A McConnachie, Josefin Koehn, Loren Kinman, Danny D Shen

J Pharm Sci· May 2020

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Pharmacodynamics of Metformin in Pregnant Women With Gestational Diabetes Mellitus and Nonpregnant Women With Type 2 Diabetes Mellitus.
Diana L Shuster, Laura M Shireman, Xiaosu Ma, Danny D Shen, Shannon K Flood Nichols

J Clin Pharmacol· April 2020

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Influence of St. John's Wort on Intravenous Fentanyl Pharmacokinetics, Pharmacodynamics, and Clinical Effects: A Randomized Clinical Trial.
Michael J Loughren, Evan D Kharasch, Megan C Kelton-Rehkopf, Karen L Syrjala, Danny D Shen

Anesthesiology· March 2020

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The Impact of Proximal Roux-en-Y Gastric Bypass Surgery on Acetaminophen Absorption and Metabolism.
Kuan-Fu Chen, Lingtak-Neander Chan, Taurence D Senn, Brant K Oelschlager, David R Flum, Danny D Shen

Pharmacotherapy· March 2020

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Dexmedetomidine Pharmacokinetics in Neonates with Hypoxic-Ischemic Encephalopathy Receiving Hypothermia.
Ryan M McAdams, Daniel Pak, Bojan Lalovic, Brian Phillips, Danny D Shen

Anesthesiol Res Pract· February 2020

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Interrogation of CYP2D6 Structural Variant Alleles Improves the Correlation Between CYP2D6 Genotype and CYP2D6-Mediated Metabolic Activity.
Rachel Dalton, Seung-Been Lee, Katrina G Claw, Bhagwat Prasad, Brian R Phillips, Danny D Shen

Clin Transl Sci· January 2020

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Effect of N-Acetyltransferase 2 Genotype on the Pharmacokinetics of Hydralazine During Pregnancy.
Lyrialle W Han, Rachel J Ryu, Michael Cusumano, Thomas R Easterling, Brian R Phillips, Danny D Shen

J Clin Pharmacol· December 2019

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Reevaluating the role of megalin in renal vitamin D homeostasis using a human cell-derived microphysiological system.
Brian D Chapron, Alenka Chapron, Brian Phillips, Miracle C Okoli, Danny D Shen

ALTEX· February 2019

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Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates.
Simone Perazzolo, Laura M Shireman, Josefin Koehn, Lisa A McConnachie, John C Kraft, Danny D Shen

J Pharm Sci· December 2018

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Gut Microbiota Modulates Interactions Between Polychlorinated Biphenyls and Bile Acid Homeostasis.
Sunny Lihua Cheng, Xueshu Li, Hans-Joachim Lehmler, Brian Phillips, Danny Shen

Toxicol Sci· December 2018

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