Publications by authors named "Darian Bartkowski"

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Development of CVN424: A Selective and Novel GPR6 Inverse Agonist Effective in Models of Parkinson Disease.
Nicola L Brice, Hans H Schiffer, Holger Monenschein, Victoria J Mulligan, Keith Page, Darian Bartkowski

J Pharmacol Exp Ther· June 2021

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Using Target Engagement Biomarkers to Predict Clinical Efficacy of MetAP2 Inhibitors.
Pamela J Farrell, Christopher J Zopf, Huey-Jing Huang, Deepika Balakrishna, Corine Holub, Darian Bartkowski

J Pharmacol Exp Ther· November 2019

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Effective targeting of Hedgehog signaling in a medulloblastoma model with PF-5274857, a potent and selective Smoothened antagonist that penetrates the blood-brain barrier.
Allison Rohner, Mary E Spilker, Justine L Lam, Bernadette Pascual, Darian Bartkowski

Mol Cancer Ther· January 2012

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Effects of p38 MAPK inhibition on early stages of diabetic retinopathy and sensory nerve function.
Yunpeng Du, Jie Tang, Guangyuan Li, Liliana Berti-Mattera, Chieh Allen Lee, Darian Bartkowski

Invest Ophthalmol Vis Sci· April 2010

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5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
David A Ellis, Julie K Blazel, Chinh V Tran, Frank Ruebsam, Douglas E Murphy, Darian M Bartkowski

Bioorg Med Chem Lett· November 2009

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Douglas E Murphy, Chinh V Tran, Lian-Sheng Li, Jingjing Zhao, Darian M Bartkowski

Bioorg Med Chem Lett· November 2009

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5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Chinh V Tran, Lian-Sheng Li, Sun Hee Kim, Alan X Xiang, Darian M Bartkowski

Bioorg Med Chem Lett· January 2009

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Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Zhongxiang Sun, Benjamin K Ayida, Stephen E Webber, Yuefen Zhou, Darian M Bartkowski

Bioorg Med Chem Lett· September 2008

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4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
David A Ellis, Julie K Blazel, Stephen E Webber, Chinh V Tran, Peter S Dragovich, Darian M Bartkowski

Bioorg Med Chem Lett· August 2008

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Sun Hee Kim, Martin T Tran, Frank Ruebsam, Alan X Xiang, Benjamin Ayida, Darian M Bartkowski

Bioorg Med Chem Lett· July 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Maria V Sergeeva, Yuefen Zhou, Darian M Bartkowski, Thomas G Nolan, Daniel A Norris

Bioorg Med Chem Lett· June 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Lian-Sheng Li, Yuefen Zhou, Douglas E Murphy, Nebojsa Stankovic, Jingjing Zhao, Darian M Bartkowski

Bioorg Med Chem Lett· June 2008

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Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Stephen E Webber, Martin T Tran, Chinh V Tran, Douglas E Murphy, Darian M Bartkowski

Bioorg Med Chem Lett· June 2008

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Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.
Alan X Xiang, Stephen E Webber, Bradley M Kerr, Erik J Rueden, Joseph R Lennox, Darian M Bartkowski

Nucleosides Nucleotides Nucleic Acids· February 2008

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