Publications by authors named "Daryl Walter"

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Discovery of , a Selective CNS Penetrant Chemical Probe as Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist.
Stefanie Mesch, Daryl Walter, Alexis Laux-Biehlmann, Daniel Basting, Stuart Flanagan

J Med Chem· January 2023

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Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors.
Scott H Henderson, Fiona Sorrell, James Bennett, Oleg Fedorov, Marcus T Hanley, Daryl S Walter

J Med Chem· August 2021

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Discovery and optimization of pyridyl-cycloalkyl-carboxylic acids as inhibitors of microsomal prostaglandin E synthase-1 for the treatment of endometriosis.
Marcus Koppitz, Nico Bräuer, Antonius Ter Laak, Horst Irlbacher, Andrea Rotgeri, Daryl Walter

Bioorg Med Chem Lett· September 2019

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Identification of a Benzimidazolecarboxylic Acid Derivative (BAY 1316957) as a Potent and Selective Human Prostaglandin E2 Receptor Subtype 4 (hEP4-R) Antagonist for the Treatment of Endometriosis.
Stefan Bäurle, Jens Nagel, Olaf Peters, Nico Bräuer, Antonius Ter Laak, Daryl Walter

J Med Chem· March 2019

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Cobalt versus Osmium: Control of Both trans and cis Selectivity in Construction of the EFG Rings of Pectenotoxin 4.
Ahria Roushanbakhti, Yifan Liu, Paul C M Winship, Michael J Tucker, Wasim M Akhtar, Daryl S Walter

Angew Chem Int Ed Engl· November 2017

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Metabolism and pharmacokinetics of JM6 in mice: JM6 is not a prodrug for Ro-61-8048.
Maria G Beconi, Dawn Yates, Kathryn Lyons, Kim Matthews, Steve Clifton, Daryl Walter

Drug Metab Dispos· December 2012

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The neuroprotective effect of a specific P2X₇ receptor antagonist derives from its ability to inhibit assembly of the NLRP3 inflammasome in glial cells.
Niamh Murphy, Thelma R Cowley, Jill C Richardson, David Virley, Neil Upton, Daryl Walter

Brain Pathol· May 2012

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The influence of exocyclic stereochemistry on the tethered aminohydroxylation reaction.
Timothy J Donohoe, Adam R Lacy, Akshat H Rathi, Daryl S Walter

Chem Asian J· December 2011

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Identification of 2-oxo-N-(phenylmethyl)-4-imidazolidinecarboxamide antagonists of the P2X(7) receptor.
Lee Abberley, Aude Bebius, Paul J Beswick, Andy Billinton, Katharine L Collis, Daryl S Walter

Bioorg Med Chem Lett· November 2010

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A novel oxidative cyclisation onto vinyl silanes.
Timothy J Donohoe, Paul C M Winship, Ben S Pilgrim, Daryl S Walter, Cedric K A Callens

Chem Commun (Camb)· October 2010

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Discovery and structure-activity relationships of a series of pyroglutamic acid amide antagonists of the P2X7 receptor.
Muna H Abdi, Paul J Beswick, Andy Billinton, Laura J Chambers, Andrew Charlton, Daryl S Walter

Bioorg Med Chem Lett· September 2010

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BACE-1 hydroxyethylamine inhibitors using novel edge-to-face interaction with Arg-296.
Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Daryl S Walter

Bioorg Med Chem Lett· August 2010

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Structure-activity relationships and in vivo activity of (1H-pyrazol-4-yl)acetamide antagonists of the P2X(7) receptor.
Paul J Beswick, Andy Billinton, Laura J Chambers, David K Dean, Elena Fonfria, Daryl S Walter

Bioorg Med Chem Lett· August 2010

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Synthesis and biological activity of a series of tetrasubstituted-imidazoles as P2X(7) antagonists.
Robert J Gleave, Daryl S Walter, Paul J Beswick, Elena Fonfria, Anton D Michel

Bioorg Med Chem Lett· August 2010

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Synthesis and structure-activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor.
Laura J Chambers, Alexander J Stevens, Andrew P Moses, Anton D Michel, Daryl S Walter

Bioorg Med Chem Lett· May 2010

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A Lewis acid promoted oxidative cyclization.
Timothy J Donohoe, Paul C M Winship, Daryl S Walter

J Org Chem· August 2009

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Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Daryl S Walter

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Daryl S Walter

Bioorg Med Chem Lett· July 2009

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Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent.
Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Daryl S Walter

Bioorg Med Chem Lett· July 2009

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Mechanism of action of species-selective P2X(7) receptor antagonists.
Anton D Michel, Sin-Wei Ng, Shilina Roman, William C Clay, David K Dean, Daryl S Walter

Br J Pharmacol· April 2009

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Second generation of hydroxyethylamine BACE-1 inhibitors: optimizing potency and oral bioavailability.
Nicolas Charrier, Brian Clarke, Leanne Cutler, Emmanuel Demont, Colin Dingwall, Daryl S Walter

J Med Chem· June 2008

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BACE-1 inhibitors part 2: identification of hydroxy ethylamines (HEAs) with reduced peptidic character.
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Daryl S Walter

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 1: identification of novel hydroxy ethylamines (HEAs).
Brian Clarke, Emmanuel Demont, Colin Dingwall, Rachel Dunsdon, Andrew Faller, Daryl S Walter

Bioorg Med Chem Lett· February 2008

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BACE-1 inhibitors part 3: identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells.
Paul Beswick, Nicolas Charrier, Brian Clarke, Emmanuel Demont, Colin Dingwall, Daryl S Walter

Bioorg Med Chem Lett· February 2008

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A new route to highly functionalized heterocyclic rings.
Philip J Parsons, Alexander J Waters, Daryl S Walter, Johnathan Board

J Org Chem· February 2007

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