Publications by authors named "David Croucher"

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Cell-penetrant peptides as novel inhibitors of the interaction of coatomer protein COPB2/RACK2 with protein kinase Cε and cargo proteins.
Abisola A Olushola-Siedoks, Lewin Small, Kathryn J Fincham, Dorothy C C Wai, Dhruv Monteiro, David R Croucher

Biochim Biophys Acta Mol Cell Res· January 2026

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Inclusion of JNK-independent drugs within multiagent chemotherapy improves response in relapsed high-risk neuroblastoma.
Jeremy Z R Han, Monica Phimmachanh, Jordan F Hastings, King Ho Leong, Boaz H Ng, David R Croucher

Sci Adv· November 2025

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JNK pathway suppression mediates insensitivity to combination endocrine therapy and CDK4/6 inhibition in ER+ breast cancer.
Sarah Alexandrou, Christine S Lee, Kristine J Fernandez, Celine E Wiharja, Leila Eshraghi, David R Croucher

J Exp Clin Cancer Res· August 2025

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Targeting the NPY/NPY1R signaling axis in mutant p53-dependent pancreatic cancer impairs metastasis.
Cecilia R Chambers, Supitchaya Watakul, Peter Schofield, Anna E Howell, Jessie Zhu, David R Croucher

Sci Adv· March 2025

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PSKH1 kinase activity is differentially modulated via allosteric binding of Ca sensor proteins.
Christopher R Horne, Toby A Dite, Samuel N Young, Lucy J Mather, Laura F Dagley, David R Croucher

Proc Natl Acad Sci U S A· February 2025

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Activation of CAMK2 by pseudokinase PEAK1 represents a targetable pathway in triple negative breast cancer.
Xue Yang, Xiuquan Ma, Tianyue Zhao, David R Croucher, Elizabeth V Nguyen

Nat Commun· February 2025

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Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically "actionable" signalling axis in triple negative breast cancer.
Xue Yang, Xiuquan Ma, Tianyue Zhao, David R Croucher, Elizabeth V Nguyen

bioRxiv· November 2024

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Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.
Brooke A Pereira, Shona Ritchie, Cecilia R Chambers, Katie A Gordon, Astrid Magenau, David R Croucher

Sci Adv· July 2024

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Tumor Biomechanics Alters Metastatic Dissemination of Triple Negative Breast Cancer via Rewiring Fatty Acid Metabolism.
Elysse C Filipe, Sipiththa Velayuthar, Ashleigh Philp, Max Nobis, Sharissa L Latham, David R Croucher

Adv Sci (Weinh)· June 2024

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A first-in-class pan-lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer.
Jessica L Chitty, Michelle Yam, Lara Perryman, Amelia L Parker, Joanna N Skhinas, David R Croucher

Nat Cancer· September 2023

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Human PIK3R1 mutations disrupt lymphocyte differentiation to cause activated PI3Kδ syndrome 2.
Tina Nguyen, Anthony Lau, Julia Bier, Kristen C Cooke, Helen Lenthall, David R Croucher

J Exp Med· June 2023

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Monitoring AKT activity and targeting in live tissue and disease contexts using a real-time Akt-FRET biosensor mouse.
James R W Conway, Sean C Warren, Young-Kyung Lee, Andrew T McCulloch, Astrid Magenau, David R Croucher

Sci Adv· April 2023

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Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma.
Jordan F Hastings, Sharissa L Latham, Alvin Kamili, Madeleine S Wheatley, Jeremy Z R Han, David R Croucher

Sci Adv· March 2023

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Mepolizumab decreases tissue eosinophils while increasing type-2 cytokines in eosinophilic chronic rhinosinusitis.
Sophie Walter, Jacqueline Ho, Raquel Alvarado, Greg Smith, David R Croucher

Clin Exp Allergy· December 2022

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Non-kinase targeting of oncogenic c-Jun N-terminal kinase (JNK) signaling: the future of clinically viable cancer treatments.
Sharissa L Latham, Yolande E I O'Donnell, David R Croucher

Biochem Soc Trans· December 2022

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Temporal profiling of the breast tumour microenvironment reveals collagen XII as a driver of metastasis.
Michael Papanicolaou, Amelia L Parker, Michelle Yam, Elysse C Filipe, Sunny Z Wu, David R Croucher

Nat Commun· August 2022

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Prostate cancer cell proliferation is influenced by LDL-cholesterol availability and cholesteryl ester turnover.
Nikki L Raftopulos, Tinashe C Washaya, Andreas Niederprüm, Antonia Egert, Mariam F Hakeem-Sanni, David R Croucher

Cancer Metab· January 2022

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Bisphosphonate drugs have actions in the lung and inhibit the mevalonate pathway in alveolar macrophages.
Marcia A Munoz, Emma K Fletcher, Oliver P Skinner, Julie Jurczyluk, Esther Kristianto, David R Croucher

Elife· December 2021

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Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.
Hui-Ming Lin, Nicole Yeung, Jordan F Hastings, David R Croucher, Kevin Huynh

Cancers (Basel)· October 2021

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Optimizing metastatic-cascade-dependent Rac1 targeting in breast cancer: Guidance using optical window intravital FRET imaging.
Alessia Floerchinger, Kendelle J Murphy, Sharissa L Latham, Sean C Warren, Andrew T McCulloch, David R Croucher

Cell Rep· September 2021

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In Vitro 3D Models of Tunable Stiffness.
Elysse C Filipe, Amelia L Parker, Antonia L Cadell, Gretel Major, David R Croucher

Methods Mol Biol· June 2021

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Personalized Medicine for Neuroblastoma: Moving from Static Genotypes to Dynamic Simulations of Drug Response.
Jeremy Z R Han, Jordan F Hastings, Monica Phimmachanh, Dirk Fey, Walter Kolch, David R Croucher

J Pers Med· May 2021

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A zebrafish functional genomics model to investigate the role of human A20 variants in vivo.
Daniele Cultrone, Nathan W Zammit, Eleanor Self, Benno Postert, Jeremy Z R Han, David R Croucher

Sci Rep· November 2020

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Histone Deacetylases and Histone Deacetylase Inhibitors in Neuroblastoma.
Monica Phimmachanh, Jeremy Z R Han, Yolande E I O'Donnell, Sharissa L Latham, David R Croucher

Front Cell Dev Biol· October 2020

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