Publications by authors named "David Hava"

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Rational Engineering of Nissle 1917 as Live Biotherapeutic to Degrade Uremic Toxin Precursors.
David Lubkowicz, David L Hava, Kim Lewis, Vincent M Isabella

ACS Synth Biol· April 2024

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The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers.
Mylène Perreault, Jillian Means, Erik Gerson, Michael James, Sean Cotton, David L Hava

Cell Host Microbe· March 2024

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Lactate limits CNS autoimmunity by stabilizing HIF-1α in dendritic cells.
Liliana M Sanmarco, Joseph M Rone, Carolina M Polonio, Gonzalo Fernandez Lahore, Federico Giovannoni, David Hava

Nature· August 2023

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Phase I Study of SYNB1891, an Engineered E. coli Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies.
Jason J Luke, Sarina A Piha-Paul, Theresa Medina, Claire F Verschraegen, Mary Varterasian, David L Hava

Clin Cancer Res· July 2023

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Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice.
Tetsuya Kouno, Suling Zeng, Yanhan Wang, Yi Duan, Sonja Lang, David L Hava

Alcohol Clin Exp Res (Hoboken)· May 2023

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Engineered probiotics limit CNS autoimmunity by stabilizing HIF-1α in dendritic cells.
Liliana M Sanmarco, Joseph M Rone, Carolina M Polonio, Federico Giovannoni, Gonzalo Fernandez Lahore, David Hava

bioRxiv· March 2023

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Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster.
Aida Kalantari, Michael J James, Lauren A Renaud, Mylene Perreault, Catherine E Monahan, David L Hava

PLoS One· February 2023

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Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation.
Sara Federici, Sharon Kredo-Russo, Rafael Valdés-Mas, Denise Kviatcovsky, Eyal Weinstock, Hava Ben-David

Cell· August 2022

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An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria.
David Lubkowicz, Nicholas G Horvath, Michael J James, Pasquale Cantarella, Lauren Renaud, David L Hava

Mol Syst Biol· March 2022

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Synthetic biology: at the crossroads of genetic engineering and human therapeutics-a Keystone Symposia report.
Jennifer Cable, Joshua N Leonard, Timothy K Lu, Zhen Xie, Matthew Wook Chang, David L Hava

Ann N Y Acad Sci· December 2021

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Allergic Diseases Caused by Species in Patients with Cystic Fibrosis.
Aidan K Curran, David L Hava

Antibiotics (Basel)· March 2021

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A New Natural Defense Against Airborne Pathogens.
David Edwards, Anthony Hickey, Richard Batycky, Lester Griel, Michael Lipp, David Hava

QRB Discov· July 2020

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A phase 1/1b study of PUR1900, an inhaled formulation of itraconazole, in healthy volunteers and asthmatics to study safety, tolerability and pharmacokinetics.
David L Hava, Lisa Tan, Patrick Johnson, Aidan K Curran, Jason Perry

Br J Clin Pharmacol· April 2020

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Pulmonary and Regional Deposition of Nebulized and Dry Powder Aerosols in Ferrets.
Philip J Kuehl, Ramesh Chand, Jacob D McDonald, David L Hava, Wesley H DeHaan

AAPS PharmSciTech· July 2019

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Particle size and gastrointestinal absorption influence tiotropium pharmacokinetics: a pilot bioequivalence study of PUR0200 and Spiriva HandiHaler.
Jason Perry, Brian Trautman, Joe Takher-Smith, Steve Kramer, Katie Kane, David L Hava

Br J Clin Pharmacol· March 2019

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Inhaled calcium salts inhibit tobacco smoke-induced inflammation by modulating expression of chemokines and cytokines.
Paulette W Andreotta, Steve Arold, Jennifer Kenyon, Diane Spicer, Paul Woodman, David L Hava

Pulm Pharmacol Ther· December 2018

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Toll-like receptor 2 is overexpressed in Familial Mediterranean fever patients and is inhibited by colchicine treatment.
Hava Ben-David, Avi Livneh, Merav Lidar, Olga Feld, Souad Haj Yahia

Best Pract Res Clin Rheumatol· October 2018

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The pharmacokinetics, pharmacodynamics and tolerability of PUR0200, a novel tiotropium formulation, in chronic obstructive pulmonary disease.
Dave Singh, Arjun Ravi, Katie Kane, Tess Schmalbach, David L Hava

Br J Clin Pharmacol· September 2018

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Calcium restores the macrophage response to nontypeable haemophilus influenzae in chronic obstructive pulmonary disease.
Karin A Provost, Miyuki Smith, Stephen P Arold, David L Hava, Sanjay Sethi

Am J Respir Cell Mol Biol· June 2015

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Lysosomal trafficking, antigen presentation, and microbial killing are controlled by the Arf-like GTPase Arl8b.
Salil Garg, Mahak Sharma, Cindy Ung, Amit Tuli, Duarte C Barral, David L Hava

Immunity· August 2011

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A role for the B-cell CD74/macrophage migration inhibitory factor pathway in the immunomodulation of systemic lupus erythematosus by a therapeutic tolerogenic peptide.
Smadar Lapter, Hava Ben-David, Amir Sharabi, Heidy Zinger, Alona Telerman

Immunology· January 2011

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A tolerogenic peptide down-regulates mature B cells in bone marrow of lupus-afflicted mice by inhibition of interleukin-7, leading to apoptosis.
Hava Ben-David, Amir Sharabi, Reshmi Parameswaran, Heidy Zinger, Edna Mozes

Immunology· October 2009

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B-cell activating factor (BAFF) plays a role in the mechanism of action of a tolerogenic peptide that ameliorates lupus.
Reshmi Parameswaran, Hava Ben David, Amir Sharabi, Heidy Zinger, Edna Mozes

Clin Immunol· May 2009

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Apical membrane maturation and cellular rosette formation during morphogenesis of the zebrafish lateral line.
David Hava, Ulrike Forster, Miho Matsuda, Shuang Cui, Brian A Link

J Cell Sci· March 2009

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Evasion of peptide, but not lipid antigen presentation, through pathogen-induced dendritic cell maturation.
David L Hava, Nicole van der Wel, Nadia Cohen, Christopher C Dascher, Diane Houben

Proc Natl Acad Sci U S A· August 2008

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