Publications by authors named "David Roush"

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Flow-through polishing of Protein A eluates: Removal of high and low molecular weight impurities by size-exclusion-mixed-mode chromatography.
Jacob P LeBarre, Wenning Chu, Ka Zhang, Dipendra Bhandari, Cristiana Boi, David Roush

J Chromatogr A· September 2025

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Integration of QSAR models with high throughput screening to accelerate the development of polishing chromatography unit operations.
Michael Hartmann, Michael Rauscher, Julie Robinson, John Welsh, David Roush

J Chromatogr A· April 2025

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Current state of implementation of in silico tools in the biopharmaceutical industry-Proceedings of the 5th modeling workshop.
Felix Wittkopp, John Welsh, Robert Todd, Arne Staby, David Roush

Biotechnol Bioeng· September 2024

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Insulin purification-Innovation continuum via synthesis of fundamentals, technology, and modeling.
David Roush, Michael Iammarino, Rebecca Chmielowski, Francis Insaidoo, Mark A McCoy

Biotechnol Bioeng· August 2024

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Exploring preferred binding domains of IgG1 mAbs to multimodal adsorbents using a combined biophysics and simulation approach.
Kabir Dhingra, Imee Sinha, Mark Snyder, David Roush, Steven M Cramer

Biotechnol Prog· April 2024

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Factors affecting product association as a mechanism of host-cell protein persistence in bioprocessing.
Young Hoon Oh, Matthew L Becker, Kerri M Mendola, Leila H Choe, Lie Min, David J Roush

Biotechnol Bioeng· April 2024

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Mixed-mode size-exclusion silica resin for polishing human antibodies in flow-through mode.
Jacob P LeBarre, Wenning Chu, Scott H Altern, Andrew J Kocot, Dipendra Bhandari, David Roush

J Chromatogr A· April 2024

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Mechanistic model-based characterization of size-exclusion-mixed-mode resins for removal of monoclonal antibody fragments.
Scott H Altern, Andrew J Kocot, Jacob P LeBarre, Cristiana Boi, Michael W Phillips, David J Roush

J Chromatogr A· March 2024

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Identification and characterization of CHO host-cell proteins in monoclonal antibody bioprocessing.
Young Hoon Oh, Kerri M Mendola, Leila H Choe, Lie Min, Ashton R Lavoie, David J Roush

Biotechnol Bioeng· January 2024

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Characterization and implications of host-cell protein aggregates in biopharmaceutical processing.
Young Hoon Oh, Matthew L Becker, Kerri M Mendola, Leila H Choe, Lie Min, David J Roush

Biotechnol Bioeng· April 2023

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Proceedings of the 2019 Viral Clearance Symposium, Session 4: Viral Clearance Strategy and Process Understanding.
David Roush, Johannes Blümel

PDA J Pharm Sci Technol· August 2022

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Towards continuous mAb purification: Clearance of host cell proteins from CHO cell culture harvests via "flow-through affinity chromatography" using peptide-based adsorbents.
Sobhana Alekhya Sripada, Wenning Chu, Taufika Islam Williams, Matthew A Teten, Brian J Mosley, David J Roush

Biotechnol Bioeng· July 2022

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Scale-up issues for commercial depth filters in bioprocessing.
Negin Nejatishahidein, Minyoung Kim, Seon Y Jung, Ehsan E Borujeni, Lara Fernandez-Cerezo, David J Roush

Biotechnol Bioeng· April 2022

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The measurement and control of high-risk host cell proteins for polysorbate degradation in biologics formulation.
Xuanwen Li, Fengqiang Wang, Hong Li, Douglas D Richardson, David J Roush

Antib Ther· January 2022

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Probing IgG1 F-Multimodal Nanoparticle Interactions: A Combined Nuclear Magnetic Resonance and Molecular Dynamics Simulations Approach.
Ronak B Gudhka, Mayank Vats, Camille L Bilodeau, Scott A McCallum, Mark A McCoy, David J Roush

Langmuir· October 2021

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Behavior of Water Near Multimodal Chromatography Ligands and Its Consequences for Modulating Protein-Ligand Interactions.
Camille L Bilodeau, Edmond Y Lau, David J Roush, Mark A Snyder, Steven M Cramer

J Phys Chem B· June 2021

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Identification of preferred multimodal ligand-binding regions on IgG1 F using nuclear magnetic resonance and molecular dynamics simulations.
Ronak B Gudhka, Camille L Bilodeau, Scott A McCallum, Mark A McCoy, David J Roush

Biotechnol Bioeng· February 2021

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Toward in silico CMC: An industrial collaborative approach to model-based process development.
David Roush, Dilip Asthagiri, Deenesh K Babi, Steve Benner, Camille Bilodeau

Biotechnol Bioeng· December 2020

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Effectiveness of host cell protein removal using depth filtration with a filter containing diatomaceous earth.
Negin Nejatishahidein, Ehsan E Borujeni, David J Roush, Andrew L Zydney

Biotechnol Prog· November 2020

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A direct RT qPCR method for quantification of retrovirus-like particles in biopharmaceutical production with CHO cells.
Musaddeq Hussain, William J Rayfield, David J Roush

J Pharm Biomed Anal· September 2020

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A thermodynamic evaluation of antibody-surface interactions in multimodal cation exchange chromatography.
Ronak B Gudhka, David J Roush, Steven M Cramer

J Chromatogr A· September 2020

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Highland games: A benchmarking exercise in predicting biophysical and drug properties of monoclonal antibodies from amino acid sequences.
Jonathan Coffman, Bruno Marques, Raquel Orozco, Minni Aswath, Hasan Mohammad, David Roush

Biotechnol Bioeng· July 2020

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Viral contamination in biologic manufacture and implications for emerging therapies.
Paul W Barone, Michael E Wiebe, James C Leung, Islam T M Hussein, Flora J Keumurian, David Roush

Nat Biotechnol· May 2020

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The effect of pH on antibody retention in multimodal cation exchange chromatographic systems.
Julie Robinson, David Roush, Steven M Cramer

J Chromatogr A· April 2020

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Formation of Ligand Clusters on Multimodal Chromatographic Surfaces.
Camille L Bilodeau, Edmond Y Lau, David Roush, Shekhar Garde, Steven M Cramer

Langmuir· December 2019

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