Publications by authors named "Duncan Holmes"

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Lecture Capture, Transcripts, and Captioning in US Colleges of Osteopathic Medicine: Descriptive Cross-Sectional Survey.
Phillip Khong, Duncan Holmes, Bahar Masoudian, Gregg C Lund, Steven Garwood

Med Sci Educ· April 2025

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Optimization of Potent and Selective Cyclohexyl Acid ERAP1 Inhibitors Using Structure- and Property-Based Drug Design.
Ross P Hryczanek, Andrew S Hackett, Paul Rowland, Chun-Wa Chung, Máire A Convery, Duncan S Holmes

ACS Med Chem Lett· December 2024

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A Potent and Selective Kallikrein-5 Inhibitor Delivers High Pharmacological Activity in Skin from Patients with Netherton Syndrome.
John Liddle, Veronique Beneton, Matthew Benson, Ryan Bingham, Anne Bouillot, Duncan S Holmes

J Invest Dermatol· September 2021

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GSK137, a potent small-molecule BCL6 inhibitor with in vivo activity, suppresses antibody responses in mice.
Andrew C Pearce, Mark J Bamford, Ruth Barber, Angela Bridges, Maire A Convery, Duncan S Holmes

J Biol Chem· August 2021

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The development of highly potent and selective small molecule correctors of Z α-antitrypsin misfolding.
John Liddle, Andrew C Pearce, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Duncan S Holmes

Bioorg Med Chem Lett· June 2021

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Development of a small molecule that corrects misfolding and increases secretion of Z α -antitrypsin.
David A Lomas, James A Irving, Christopher Arico-Muendel, Svetlana Belyanskaya, Andrew Brewster, Duncan S Holmes

EMBO Mol Med· March 2021

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Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'.
David J Hirst, Martin Brandt, Gordon Bruton, Erica Christodoulou, Leanne Cutler, Duncan S Holmes

Bioorg Med Chem Lett· November 2020

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Identification, preclinical profile, and clinical proof of concept of an orally bioavailable pro-drug of miridesap.
Duncan Richards, Mark Bamford, Lia Liefaard, Nazneen Haque, Gareth Lewis, Duncan S Holmes

Br J Pharmacol· April 2020

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Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
John Liddle, Jonathan P Hutchinson, Semra Kitchen, Paul Rowland, Margarete Neu, Duncan S Holmes

J Med Chem· March 2020

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Corrigendum to 'Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors' [Bioorg. Med. Chem. Lett. 29 (2019) 126675].
Ann L Walker, Alexis Denis, Ryan P Bingham, Anne Bouillot, Emma V Edgar, Duncan S Holmes

Bioorg Med Chem Lett· January 2020

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Design and development of a series of borocycles as selective, covalent kallikrein 5 inhibitors.
Ann L Walker, Alexis Denis, Ryan P Bingham, Anne Bouillot, Emma V Edgar, Duncan S Holmes

Bioorg Med Chem Lett· October 2019

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Structure guided drug design to develop kallikrein 5 inhibitors to treat Netherton syndrome.
Ann L Walker, Ryan P Bingham, Emma V Edgar, Alan Ferrie, Duncan S Holmes

Bioorg Med Chem Lett· June 2019

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Evaluation of a crystallographic surrogate for kallikrein 5 in the discovery of novel inhibitors for Netherton syndrome.
James H Thorpe, Emma V Edgar, Kathrine J Smith, Xiao Q Lewell, Monika Rella, Duncan S Holmes

Acta Crystallogr F Struct Biol Commun· May 2019

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Kallikrein 5 inhibitors identified through structure based drug design in search for a treatment for Netherton Syndrome.
Gemma V White, Emma V Edgar, Duncan S Holmes, Xiao Qing Lewell, John Liddle

Bioorg Med Chem Lett· March 2019

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Identification of selective 8-(piperidin-4-yloxy)quinoline sulfone and sulfonamide histamine H receptor antagonists for use in allergic rhinitis.
Panayiotis A Procopiou, Alison J Ford, Paul M Gore, Ashley P Hancock, Simon T Hodgson, Duncan S Holmes

Bioorg Med Chem Lett· November 2017

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In search of a small molecule agonist of the relaxin receptor RXFP1 for the treatment of liver fibrosis.
Andrew McBride, Anna M Hoy, Mark J Bamford, Danuta E Mossakowska, Martin P Ruediger, Duncan S Holmes

Sci Rep· September 2017

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Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Jonathan P Hutchinson, Paul Rowland, Mark R D Taylor, Erica M Christodoulou, Carl Haslam, Duncan S Holmes

Nat Commun· June 2017

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The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
John Liddle, Benjamin Beaufils, Margaret Binnie, Anne Bouillot, Alexis A Denis, Duncan S Holmes

Bioorg Med Chem Lett· May 2017

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Design of Phthalazinone Amide Histamine H Receptor Antagonists for Use in Rhinitis.
Panayiotis A Procopiou, Alison J Ford, Paul M Gore, Brian E Looker, Simon T Hodgson, Duncan S Holmes

ACS Med Chem Lett· May 2017

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Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
Ann L Walker, Nicolas Ancellin, Benjamin Beaufils, Marylise Bergeal, Margaret Binnie, Duncan S Holmes

J Med Chem· April 2017

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The discovery of quinoline based single-ligand human H and H receptor antagonists.
Panayiotis A Procopiou, Rachael A Ancliff, Paul M Gore, Ashley P Hancock, Simon T Hodgson, Duncan S Holmes

Bioorg Med Chem Lett· December 2016

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Discovery of Tetrahydropyrazolopyridine as Sphingosine 1-Phosphate Receptor 3 (S1P3)-Sparing S1P1 Agonists Active at Low Oral Doses.
Emmanuel H Demont, James M Bailey, Rino A Bit, Jack A Brown, Colin A Campbell, Duncan S Holmes

J Med Chem· February 2016

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Kynurenine-3-monooxygenase inhibition prevents multiple organ failure in rodent models of acute pancreatitis.
Damian J Mole, Scott P Webster, Iain Uings, Xiaozhong Zheng, Margaret Binnie, Duncan S Holmes

Nat Med· February 2016

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Prevalence of Lead Hazards and Soil Arsenic in U.S. Housing.
F Gary Dewalt, David C Cox, Robert O'Haver, Brendon Salatino, Duncan Holmes

J Environ Health· December 2015

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Discovery of a rapidly metabolized, long-acting β(2) adrenergic receptor agonist with a short onset time incorporating a sulfone group suitable for once-daily dosing.
Panayiotis A Procopiou, Victoria J Barrett, Keith Biggadike, Peter R Butchers, Andrew Craven, Duncan S Holmes

J Med Chem· January 2014

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