Publications by authors named "Eamon Breen"

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Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of expressing naïve CD4+ T cells.
Joshua Flynn, Anne Marie Baird, Eamon Breen, Michael Carty, Ciara S McNevin

Front Immunol· November 2025

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Trained immunity is induced in humans after immunization with an adenoviral vector COVID-19 vaccine.
Dearbhla M Murphy, Donal J Cox, Sarah A Connolly, Eamon P Breen, Aenea Ai Brugman

J Clin Invest· January 2023

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von Willebrand factor links primary hemostasis to innate immunity.
Clive Drakeford, Sonia Aguila, Fiona Roche, Karsten Hokamp, Judicael Fazavana, Eamon Breen

Nat Commun· November 2022

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Study protocol for the St James's Hospital, Tallaght University Hospital, Trinity College Dublin Allied Researchers' (STTAR) Bioresource for COVID-19.
Laura O'Doherty, Stuart Hendricken Phelan, Nicole Wood, Sorcha O'Brien, Jacklyn Sui, Eamon Breen

HRB Open Res· March 2022

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Exploitation of the vitamin A/retinoic acid axis depletes ALDH1-positive cancer stem cells and re-sensitises resistant non-small cell lung cancer cells to cisplatin.
Lauren MacDonagh, Rhyla Mae Santiago, Steven G Gray, Eamon Breen, Sinead Cuffe

Transl Oncol· April 2021

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CD1d expression and invariant natural killer T-cell numbers are reduced in patients with upper gastrointestinal cancers and are further impaired by commonly used chemotherapies.
Ashanty M Melo, Melissa J Conroy, Emma K Foley, Éilis Dockry, Eamon P Breen

Cancer Immunol Immunother· June 2020

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Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis.
John Davis Coakley, Eamon P Breen, Ana Moreno-Olivera, Alhanouf I Al-Harbi, Ashanty M Melo

Vaccines (Basel)· June 2020

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Dysregulated T helper type 1 (Th1) and Th17 responses in elderly hospitalised patients with infection and sepsis.
John D Coakley, Eamon P Breen, Ana Moreno-Olivera, Alhanouf I Al-Harbi, Ashanty M Melo

PLoS One· March 2020

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BBI608 inhibits cancer stemness and reverses cisplatin resistance in NSCLC.
Lauren MacDonagh, Steven G Gray, Eamon Breen, Sinead Cuffe, Stephen P Finn

Cancer Lett· August 2018

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Role of matrix metalloproteinases 2 and 9, toll-like receptor 4 and platelet-leukocyte aggregate formation in sepsis-associated thrombocytopenia.
Caroline M Larkin, Nadhim Kamil Hante, Eamon P Breen, Krzysztof A Tomaszewski, Simon Eisele

PLoS One· August 2018

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Type 1 IFN Induction by Cytosolic Nucleic Acid Is Intact in Neonatal Mononuclear Cells, Contrasting Starkly with Neonatal Hyporesponsiveness to TLR Ligation Due to Independence from Endosome-Mediated IRF3 Activation.
Kiva Brennan, Bobby D O'Leary, Danielle Mc Laughlin, Eamon P Breen, Emma Connolly

J Immunol· August 2018

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Novel thioglycoside analogs of α-galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells.
Ashanty M Melo, Lei Zhang, Éilis F Dockry, Andreea Petrasca, Yasmeen G Ghnewa, Eamon P Breen

Glycobiology· July 2018

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pSTAT3 Levels Have Divergent Expression Patterns and Associations with Survival in Squamous Cell Carcinoma and Adenocarcinoma of the Oesophagus.
Katie E O' Sullivan, Adriana J Michielsen, Esther O' Regan, Mary C Cathcart, Gillian Moore, Eamon Breen

Int J Mol Sci· June 2018

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Platelet microaggregation in sepsis examined by quartz crystal microbalance with dissipation technology.
Caroline M Larkin, Eamon P Breen, Krzysztof A Tomaszewski, Simon Eisele, Marek W Radomski

Platelets· May 2018

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Human Vδ3 γδ T cells induce maturation and IgM secretion by B cells.
Andreea Petrasca, Ashanty M Melo, Eamon P Breen, Derek G Doherty

Immunol Lett· April 2018

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Targeting the cancer stem cell marker, aldehyde dehydrogenase 1, to circumvent cisplatin resistance in NSCLC.
Lauren MacDonagh, Michael F Gallagher, Brendan Ffrench, Claudia Gasch, Eamon Breen

Oncotarget· September 2017

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Lung cancer stem cells: The root of resistance.
Lauren MacDonagh, Steven G Gray, Eamon Breen, Sinead Cuffe, Stephen P Finn

Cancer Lett· March 2016

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Lack of activation of UCP1 in isolated brown adipose tissue mitochondria by glucose-O-ω-modified saturated fatty acids of various chain lengths.
Eamon P Breen, Wayne Pilgrim, Kieran J Clarke, Cristy Yssel, Mark Farrell

J Chem Biol· March 2013

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Tyrosine phosphorylation of the E3 ubiquitin ligase TRIM21 positively regulates interaction with IRF3 and hence TRIM21 activity.
Kevin B Stacey, Eamon Breen, Caroline A Jefferies

PLoS One· November 2012

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Hepatocyte entry leads to degradation of autoreactive CD8 T cells.
Volker Benseler, Alessandra Warren, Michelle Vo, Lauren E Holz, Szun S Tay, Eamon Breen

Proc Natl Acad Sci U S A· October 2011

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Dynamic regulation of uncoupling protein 2 content in INS-1E insulinoma cells.
Vian Azzu, Charles Affourtit, Eamon P Breen, Nadeene Parker, Martin D Brand

Biochim Biophys Acta· October 2008

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The E3 ubiquitin ligase Ro52 negatively regulates IFN-beta production post-pathogen recognition by polyubiquitin-mediated degradation of IRF3.
Rowan Higgs, Joan Ní Gabhann, Nadia Ben Larbi, Eamon P Breen, Katherine A Fitzgerald

J Immunol· August 2008

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Cold acclimation and oxygen consumption in the thymus.
Clare M Brennan, Eamon P Breen, Richard K Porter

Biochim Biophys Acta· November 2006

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A new automated technique for the reconstitution of hydrophobic proteins into planar bilayer membranes. Studies of human recombinant uncoupling protein 1.
Valeri Beck, Martin Jabůrek, Eamon P Breen, Richard K Porter, Petr Jezek

Biochim Biophys Acta· September 2006

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On the mechanism of mitochondrial uncoupling protein 1 function.
Eamon P Breen, Sebastien G Gouin, Andrew F Murphy, Lee R Haines, Angela M Jackson

J Biol Chem· January 2006

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