Publications by authors named "Michael Carty"

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Multi-omic analysis of PBMCs in sepsis reveals widespread cytotoxic dysfunction and an increased population of expressing naïve CD4+ T cells.
Joshua Flynn, Anne Marie Baird, Eamon Breen, Michael Carty, Ciara S McNevin

Front Immunol· November 2025

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Canonical and Non-Canonical Roles of Human DNA Polymerase η.
Salma Bedaiwi, Anam Usmani, Michael P Carty

Genes (Basel)· September 2024

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Heterocyclic Iminoquinones and Quinones from the National Cancer Institute (NCI, USA) COMPARE Analysis.
Naemah Haji, Masoma Faizi, Panayiotis A Koutentis, Michael P Carty, Fawaz Aldabbagh

Molecules· July 2023

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Publisher Correction: Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Tristram A J Ryan, Alexander Hooftman, Aisling M Rehill, Matt D Johansen, Eóin C O' Brien, Michael Carty

Nat Commun· July 2023

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Dimethyl fumarate and 4-octyl itaconate are anticoagulants that suppress Tissue Factor in macrophages via inhibition of Type I Interferon.
Tristram A J Ryan, Alexander Hooftman, Aisling M Rehill, Matt D Johansen, Eóin C O' Brien, Michael Carty

Nat Commun· June 2023

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Klebsiella pneumoniae hijacks the Toll-IL-1R protein SARM1 in a type I IFN-dependent manner to antagonize host immunity.
Claudia Feriotti, Joana Sá-Pessoa, Ricardo Calderón-González, Lili Gu, Brenda Morris, Michael Carty

Cell Rep· August 2022

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SARM1 Promotes Photoreceptor Degeneration in an Oxidative Stress Model of Retinal Degeneration.
Luke Gibbons, Ema Ozaki, Chris Greene, Anne Trappe, Michael Carty

Front Neurosci· April 2022

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DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target.
Ashlynn Ai Li Ler, Michael P Carty

Front Oncol· February 2022

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SARM1 Ablation Is Protective and Preserves Spatial Vision in an In Vivo Mouse Model of Retinal Ganglion Cell Degeneration.
Laura K Finnegan, Naomi Chadderton, Paul F Kenna, Arpad Palfi, Michael Carty

Int J Mol Sci· January 2022

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CRISPR/Cas9-mediated SARM1 knockout and epitope-tagged mice reveal that SARM1 does not regulate nuclear transcription, but is expressed in macrophages.
Ciara G Doran, Ryoichi Sugisawa, Michael Carty, Fiona Roche, Claire Fergus

J Biol Chem· December 2021

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Dual NADPH oxidases DUOX1 and DUOX2 synthesize NAADP and are necessary for Ca signaling during T cell activation.
Feng Gu, Aileen Krüger, Hannes G Roggenkamp, Rick Alpers, Dmitri Lodygin, Michael Carty

Sci Signal· November 2021

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Detection of Viral Infections by Innate Immunity.
Michael Carty, Coralie Guy, Andrew G Bowie

Biochem Pharmacol· January 2021

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SARM1 deficiency promotes rod and cone photoreceptor cell survival in a model of retinal degeneration.
Ema Ozaki, Luke Gibbons, Nuno Gb Neto, Paul Kenna, Michael Carty

Life Sci Alliance· May 2020

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Cell Survival and Cytokine Release after Inflammasome Activation Is Regulated by the Toll-IL-1R Protein SARM.
Michael Carty, Jay Kearney, Katharine A Shanahan, Emily Hams, Ryoichi Sugisawa

Immunity· June 2019

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N-Alkyl-1,5-dideoxy-1,5-imino-l-fucitols as fucosidase inhibitors: Synthesis, molecular modelling and activity against cancer cell lines.
Jian Zhou, Arvind Negi, Styliana I Mirallai, Rolf Warta, Christel Herold-Mende, Michael P Carty

Bioorg Chem· March 2019

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SARM: From immune regulator to cell executioner.
Michael Carty, Andrew G Bowie

Biochem Pharmacol· March 2019

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Poxviral protein E3-altered cytokine production reveals that DExD/H-box helicase 9 controls Toll-like receptor-stimulated immune responses.
Alan Dempsey, Sinead E Keating, Michael Carty, Andrew G Bowie

J Biol Chem· September 2018

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Selective Methylmagnesium Chloride Mediated Acetylations of Isosorbide: A Route to Powerful Nitric Oxide Donor Furoxans.
Patrick Kielty, Dennis A Smith, Peter Cannon, Michael P Carty, Michael Kennedy

Org Lett· May 2018

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Anti-Cancer Activity of Phenyl and Pyrid-2-yl 1,3-Substituted Benzo[1,2,4]triazin-7-ones and Stable Free Radical Precursors.
Lee-Ann J Keane, Styliana I Mirallai, Martin Sweeney, Michael P Carty, Georgia A Zissimou

Molecules· March 2018

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Alum Activates the Bovine NLRP3 Inflammasome.
Ciaran Harte, Aoife L Gorman, S McCluskey, Michael Carty, Andrew G Bowie

Front Immunol· November 2017

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Discovery of anti-cancer activity for benzo[1,2,4]triazin-7-ones: Very strong correlation to pleurotin and thioredoxin reductase inhibition.
Martin Sweeney, Robert Coyle, Paul Kavanagh, Andrey A Berezin, Daniele Lo Re, Michael P Carty

Bioorg Med Chem· August 2016

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SARM regulates CCL5 production in macrophages by promoting the recruitment of transcription factors and RNA polymerase II to the Ccl5 promoter.
Claudia Gürtler, Michael Carty, Jay Kearney, Stefan A Schattgen, Aihao Ding

J Immunol· May 2014

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Innate antiviral signalling in the central nervous system.
Michael Carty, Line Reinert, Søren R Paludan, Andrew G Bowie

Trends Immunol· February 2014

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DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells.
Anna M Sokol, Séverine Cruet-Hennequart, Philippe Pasero, Michael P Carty

Sci Rep· November 2013

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Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells.
Séverine Cruet-Hennequart, Áine M Prendergast, Georgina Shaw, Frank P Barry, Michael P Carty

Int J Hematol· November 2012

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