Publications by authors named "Elham Behshad"

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Discovery of a Novel Series of -Indolinone-Based Glutarimides as Highly Efficacious and Selective IKZF2 Molecular Glue Degraders.
Xuqing Zhang, Harshil Dhruv, Qiaolin Deng, Matthew Tudor, Nelisa Bechtel, Elham Behshad

J Med Chem· September 2025

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Overcoming CK1α liability in the discovery of a series of isoIndolinone Glutarimides as selective IKZF2 molecular glue degraders.
Xuqing Zhang, Qiaolin Deng, Harshil Dhruv, Matthew Tudor, Rakesh Nagilla, Elham Behshad

Bioorg Med Chem Lett· August 2025

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Discovery and Characterization of PVTX-321 as a Potent and Orally Bioavailable Estrogen Receptor Degrader for ER+/HER2- Breast Cancer.
Guozhang Xu, Courtney G Havens, Qiaolin Deng, Cassandra Lowenstein, Debangshu Samanta, Elham Behshad

J Med Chem· June 2025

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Discovery of INCB126503 as a Potent and Selective FGFR2/3 Inhibitor.
Minh H Nguyen, Anlai Wang, Lisa Truong, Ke Zhang, Hai-Fen Ye, Elham Behshad

ACS Med Chem Lett· June 2025

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Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders.
Zhenwu Li, Lalgudi S Harikrishnan, Guozhang Xu, Debangshu Samanta, Jose C Clemente, Elham Behshad

J Med Chem· January 2025

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Discovery of Orally Bioavailable FGFR2/FGFR3 Dual Inhibitors via Structure-Guided Scaffold Repurposing Approach.
Minh H Nguyen, Hai-Fen Ye, Yao Xu, Lisa Truong, April Horsey, Elham Behshad

ACS Med Chem Lett· March 2023

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Discovery of Pyrazolopyridine Derivatives as HPK1 Inhibitors.
Qinda Ye, Kai Liu, Hai-Fen Ye, Jun Pan, Alexander Sokolsky, Elham Behshad

ACS Med Chem Lett· January 2023

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Potent and Selective Biaryl Amide Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1).
Alexander Sokolsky, Oleg Vechorkin, Joshua R Hummel, Evan D Styduhar, Anlai Wang, Elham Behshad

ACS Med Chem Lett· January 2023

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Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor.
Holly K Koblish, Liangxing Wu, Liang-Chuan S Wang, Phillip C C Liu, Richard Wynn, Elham Behshad

Cancer Discov· June 2022

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The Janus kinase 2 inhibitor fedratinib inhibits thiamine uptake: a putative mechanism for the onset of Wernicke's encephalopathy.
Qiang Zhang, Yan Zhang, Sharon Diamond, Jason Boer, Jennifer J Harris, Elham Behshad

Drug Metab Dispos· October 2014

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A novel kinase inhibitor, INCB28060, blocks c-MET-dependent signaling, neoplastic activities, and cross-talk with EGFR and HER-3.
Xiangdong Liu, Qian Wang, Gengjie Yang, Cindy Marando, Holly K Koblish, Elham Behshad

Clin Cancer Res· November 2011

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Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase.
Elham Behshad, Ronald M Klabe, Alexander Margulis, Mary Becker-Pasha, Mark J Rupar

Curr Chem Genomics· April 2010

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Kinetic analysis of cysteine desulfurase CD0387 from Synechocystis sp. PCC 6803: formation of the persulfide intermediate.
Elham Behshad, J Martin Bollinger

Biochemistry· December 2009

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Evidence for conformational movement and radical mechanism in the reaction of 4-thia-L-lysine with lysine 5,6-aminomutase.
Amarendra N Maity, Chih-Pin Hsieh, Ming-Hui Huang, Yung-Han Chen, Kuo-Hsiang Tang, Elham Behshad

J Phys Chem B· September 2009

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How an enzyme tames reactive intermediates: positioning of the active-site components of lysine 2,3-aminomutase during enzymatic turnover as determined by ENDOR spectroscopy.
Nicholas S Lees, Dawei Chen, Charles J Walsby, Elham Behshad, Perry A Frey

J Am Chem Soc· August 2006

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A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase.
Frederick Berkovitch, Elham Behshad, Kuo-Hsiang Tang, Eva A Enns, Perry A Frey

Proc Natl Acad Sci U S A· November 2004

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Mechanism of cysteine desulfurase Slr0387 from Synechocystis sp. PCC 6803: kinetic analysis of cleavage of the persulfide intermediate by chemical reductants.
Elham Behshad, Sara E Parkin, J Martin Bollinger

Biochemistry· September 2004

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