Publications by authors named "Eric S Martin"

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Targeting BRAF Class II and III Mutations in NSCLC with the pan-RAF inhibitor Exarafenib Reveals ARAF-KSR1-Mediated Resistance and Rational Combination Strategies.
Tadashi Manabe, Hannah C Bergo, Qingtian Li, Tim Sen Wang, Paul Severson, Eric S Martin

Res Sq· October 2025

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The Discovery of Exarafenib (KIN-2787): Overcoming the Challenges of Pan-RAF Kinase Inhibition.
Young K Chen, Toufike Kanouni, Lee D Arnold, Jason M Cox, Elisabeth Gardiner, Eric S Martin

J Med Chem· February 2024

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Discovery of KIN-3248, An Irreversible, Next Generation FGFR Inhibitor for the Treatment of Advanced Tumors Harboring FGFR2 and/or FGFR3 Gene Alterations.
John S Tyhonas, Lee D Arnold, Jason M Cox, Aleksandra Franovic, Elisabeth Gardiner, Eric S Martin

J Med Chem· February 2024

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Resistance to dual blockade of the kinases PI3K and mTOR in KRAS-mutant colorectal cancer models results in combined sensitivity to inhibition of the receptor tyrosine kinase EGFR.
Peter J Belmont, Ping Jiang, Trevor D McKee, Tao Xie, Jason Isaacson, Eric S Martin

Sci Signal· November 2014

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Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Jatin Roper, Mark J Sinnamon, Erin M Coffee, Peter Belmont, Lily Keung, Eric S Martin

Cancer Lett· June 2014

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Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease.
Peter J Belmont, Eva Budinska, Ping Jiang, Mark J Sinnamon, Erin Coffee, Eric S Martin

Dis Model Mech· June 2014

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Overview of genetically engineered mouse models of colorectal carcinoma to enable translational biology and drug development.
Jatin Roper, Eric S Martin, Kenneth E Hung

Curr Protoc Pharmacol· June 2014

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Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation.
Eric S Martin, Peter J Belmont, Mark J Sinnamon, Larissa Georgeon Richard, Jing Yuan

Clin Cancer Res· June 2013

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Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer.
Erin M Coffee, Anthony C Faber, Jatin Roper, Mark J Sinnamon, Gautam Goel, Eric S Martin

Clin Cancer Res· May 2013

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Identification of a HMGA2-EFCAB6 gene rearrangement following next-generation sequencing in a patient with a t(12;22)(q14.3;q13.2) and JAK2V617F-positive myeloproliferative neoplasm.
S Eric Martin, Mark Sausen, Abraham Joseph, Brewster F Kingham, Eric S Martin

Cancer Genet· June 2012

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Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism.
Haoqiang Ying, Alec C Kimmelman, Costas A Lyssiotis, Sujun Hua, Gerald C Chu, Eric S Martin

Cell· April 2012

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The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer.
Jatin Roper, Michael P Richardson, Wei Vivian Wang, Larissa Georgeon Richard, Wei Chen, Eric S Martin

PLoS One· February 2012

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Telomere dysfunction induces metabolic and mitochondrial compromise.
Ergün Sahin, Simona Colla, Marc Liesa, Javid Moslehi, Florian L Müller, Eric S Martin

Nature· February 2011

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BRCA1 E1644X: a deleterious mutation in an African American individual with early onset breast cancer.
S Eric Martin, Mark Sausen, Abraham Joseph, David D Biggs, Brewster F Kingham, Eric S Martin

Breast Cancer Res Treat· January 2009

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Common and distinct genomic events in sporadic colorectal cancer and diverse cancer types.
Eric S Martin, Giovanni Tonon, Raktim Sinha, Yonghong Xiao, Bin Feng

Cancer Res· November 2007

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Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.
Richard S Maser, Bhudipa Choudhury, Peter J Campbell, Bin Feng, Kwok-Kin Wong, Eric S Martin

Nature· June 2007

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Human peripheral CD2-/lo T cells: an extrathymic population of early differentiated, developing T cells.
Matthew J Loza, Patrizia Luppi, Kerstin Kiefer, Eric S Martin, Jennifer L Szczytkowski

Int Immunol· September 2005

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High-resolution genomic profiles of human lung cancer.
Giovanni Tonon, Kwok-Kin Wong, Gautam Maulik, Cameron Brennan, Bin Feng, Eric S Martin

Proc Natl Acad Sci U S A· July 2005

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A genetic screen for candidate tumor suppressors identifies REST.
Thomas F Westbrook, Eric S Martin, Michael R Schlabach, Yumei Leng, Anthony C Liang

Cell· June 2005

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BRCA1 IVS2-2delA: a deleterious mutation in a family of Asian descent.
Eric S Martin, Carlo M Croce, David D Biggs, S Eric Martin

Cancer Genet Cytogenet· April 2004

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Alterations of the tumor suppressor gene Parkin in non-small cell lung cancer.
Maria Cristina Picchio, Eric Santos Martin, Rossano Cesari, George Adrian Calin, Sai Yendamuri

Clin Cancer Res· April 2004

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The BCSC-1 locus at chromosome 11q23-q24 is a candidate tumor suppressor gene.
Eric S Martin, Rossano Cesari, Francesca Pentimalli, Kristine Yoder, Richard Fishel, S Eric Martin

Proc Natl Acad Sci U S A· September 2003

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Parkin, a gene implicated in autosomal recessive juvenile parkinsonism, is a candidate tumor suppressor gene on chromosome 6q25-q27.
Rossano Cesari, Eric S Martin, George A Calin, Francesca Pentimalli, Roberta Bichi

Proc Natl Acad Sci U S A· May 2003

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Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression.
Roberta Bichi, Susan A Shinton, Eric S Martin, Anatoliy Koval, George A Calin

Proc Natl Acad Sci U S A· May 2002

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