Publications by authors named "Gilbert Adam"

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Nurse practitioner and physician associate mentorship: Improving retention and employment experiences.
Boyon Yun, Adam C Gilbert, Hsin-Fang Li, James M Scanlan, Andrea L Coleman

J Am Assoc Nurse Pract· October 2025

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Applications of contemporary tools to measure plasma protein binding of targeted protein degraders.
Mark Niosi, Sam Zhang, Woodrow Burchett, Carley J S Heck, Gilles H Goetz, Adam M Gilbert

Drug Metab Dispos· May 2025

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An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes.
Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Adam M Gilbert

Nat Chem Biol· March 2025

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Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M Muscarinic Acetylcholine Receptor.
Christopher R Butler, Michael Popiolek, Laura A McAllister, Erik A LaChapelle, Melissa Kramer, Adam Gilbert

J Med Chem· July 2024

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Expanding the ligandable proteome by paralog hopping with covalent probes.
Yuanjin Zhang, Zhonglin Liu, Marsha Hirschi, Oleg Brodsky, Eric Johnson, Adam M Gilbert

bioRxiv· January 2024

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Visualizing complexity: embracing graphical abstracts in the BJD.
Shehnaz Ahmed, Laura Prescott, John Caulfield, Adam Gilbert, John R Ingram

Br J Dermatol· July 2023

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Translational PK-PD for targeted protein degradation.
Derek W Bartlett, Adam M Gilbert

Chem Soc Rev· May 2022

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REL-1017 (Esmethadone) as Adjunctive Treatment in Patients With Major Depressive Disorder: A Phase 2a Randomized Double-Blind Trial.
Maurizio Fava, Stephen Stahl, Luca Pani, Sara De Martin, Marco Pappagallo, Adam Gilbert

Am J Psychiatry· February 2022

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Intramolecular Ring-Opening Decomposition of Aryl Azetidines.
Guoyun Bai, Thomas N O'Connell, Michael A Brodney, Christopher R Butler, Lara C Czabaniuk, Adam M Gilbert

ACS Med Chem Lett· October 2021

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A kinetic proofreading model for bispecific protein degraders.
Derek W Bartlett, Adam M Gilbert

J Pharmacokinet Pharmacodyn· February 2021

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Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes.
James Schiemer, Reto Horst, Yilin Meng, Justin I Montgomery, Yingrong Xu, Adam M Gilbert

Nat Chem Biol· February 2021

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Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice.
Cynthia Lebeaupin, Déborah Vallée, Déborah Rousseau, Stéphanie Patouraux, Stéphanie Bonnafous, Gilbert Adam

Hepatology· August 2018

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Inducing protein-protein interactions with molecular glues.
Ye Che, Adam M Gilbert, Veerabahu Shanmugasundaram, Mark C Noe

Bioorg Med Chem Lett· August 2018

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Delineating the role of cooperativity in the design of potent PROTACs for BTK.
Adelajda Zorba, Chuong Nguyen, Yingrong Xu, Jeremy Starr, Kris Borzilleri, Adam M Gilbert

Proc Natl Acad Sci U S A· July 2018

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Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.
Laura A McAllister, Christopher R Butler, Scot Mente, Steven V O'Neil, Kari R Fonseca, Adam M Gilbert

J Med Chem· April 2018

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Structure-Based Approach To Identify 5-[4-Hydroxyphenyl]pyrrole-2-carbonitrile Derivatives as Potent and Tissue Selective Androgen Receptor Modulators.
Ray Unwalla, James J Mousseau, Olugbeminiyi O Fadeyi, Chulho Choi, Kevin Parris, Adam M Gilbert

J Med Chem· July 2017

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Design of a Janus Kinase 3 (JAK3) Specific Inhibitor 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one (PF-06651600) Allowing for the Interrogation of JAK3 Signaling in Humans.
Atli Thorarensen, Martin E Dowty, Mary Ellen Banker, Brian Juba, Jason Jussif, Adam M Gilbert

J Med Chem· March 2017

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Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms.
Louis Leung, Xin Yang, Timothy J Strelevitz, Justin Montgomery, Matthew F Brown, Adam M Gilbert

Drug Metab Dispos· January 2017

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Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition.
Jean-Baptiste Telliez, Martin E Dowty, Lu Wang, Jason Jussif, Tsung Lin, Adam M Gilbert

ACS Chem Biol· December 2016

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Chiral Sulfoxide-Induced Single Turn Peptide α-Helicity.
Qingzhou Zhang, Fan Jiang, Bingchuan Zhao, Huacan Lin, Yuan Tian, Adam M Gilbert

Sci Rep· December 2016

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Whole genome PCR scanning (WGPS) of Coxiella burnetii strains from ruminants.
Karim Sidi-Boumedine, Gilbert Adam, Øysten Angen, Anna Aspán, Alex Bossers

Microbes Infect· October 2016

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Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.
Kay Ahn, Markus Boehm, Matthew F Brown, Jessica Calloway, Ye Che, Adam M Gilbert

ACS Chem Biol· September 2016

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Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
Kim Huard, James R Gosset, Justin I Montgomery, Adam Gilbert, Matthew M Hayward

J Med Chem· February 2016

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First Description of Infection of Caprine Herpesvirus 1 (CpHV-1) in Goats in Mainland France.
Florence Suavet, Jean-Luc Champion, Luc Bartolini, Maryline Bernou, Jean-Pierre Alzieu, Gilbert Adam

Pathogens· February 2016

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Developing predictive assays: the phenotypic screening "rule of 3".
Fabien Vincent, Paula Loria, Marko Pregel, Robert Stanton, Linda Kitching, Adam Gilbert

Sci Transl Med· June 2015

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