Publications by authors named "Gordon M Stott"

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NNMT inhibition in cancer-associated fibroblasts restores antitumour immunity.
Janna Heide, Agnes J Bilecz, Samarjit Patnaik, Maria Francesca Allega, Leonhard Donle, Gordon M Stott

Nature· September 2025

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Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors.
Neal Green, Matthew G LaPorte, William Paquette, Sipak Joyasawal, Pravat Mondal, Gordon M Stott

J Med Chem· July 2025

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Discovery of a Myeloid Cell Leukemia 1 (Mcl-1) Inhibitor That Demonstrates Potent Activities in Mouse Models of Hematological and Solid Tumors.
James C Tarr, James M Salovich, Martin Aichinger, KyuOk Jeon, Nagarathanam Veerasamy, Gordon M Stott

J Med Chem· August 2024

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Expanded profiling of WD repeat domain 5 inhibitors reveals actionable strategies for the treatment of hematologic malignancies.
Christian T Meyer, Brianna N Smith, Jing Wang, Kevin B Teuscher, Brian C Grieb, Gordon M Stott

Proc Natl Acad Sci U S A· August 2024

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Structure-Based Discovery of Potent, Orally Bioavailable Benzoxazepinone-Based WD Repeat Domain 5 Inhibitors.
Kevin B Teuscher, Jonathan J Mills, Jianhua Tian, Changho Han, Kenneth M Meyers, Gordon M Stott

J Med Chem· December 2023

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Mitochondrial-Encoded Complex I Impairment Induces a Targetable Dependency on Aerobic Fermentation in Hürthle Cell Carcinoma of the Thyroid.
Anderson R Frank, Vicky Li, Spencer D Shelton, Jiwoong Kim, Gordon M Stott

Cancer Discov· August 2023

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Optimization of 1,2,4-Triazole-Based p97 Inhibitors for the Treatment of Cancer.
Matthew G LaPorte, Celeste Alverez, Alexander Chatterley, Marina Kovaliov, Evan J Carder, Gordon M Stott

ACS Med Chem Lett· July 2023

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Structure-based discovery of potent WD repeat domain 5 inhibitors that demonstrate efficacy and safety in preclinical animal models.
Kevin B Teuscher, Somenath Chowdhury, Kenneth M Meyers, Jianhua Tian, Jiqing Sai, Gordon M Stott

Proc Natl Acad Sci U S A· January 2023

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Comparative Oncology Assessment of a Novel Inhibitor of Valosin-Containing Protein in Tumor-Bearing Dogs.
Amy K LeBlanc, Christina N Mazcko, Timothy M Fan, David M Vail, Brian K Flesner, Gordon M Stott

Mol Cancer Ther· October 2022

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Sulforaphane is Synergistic with CB-5083 and Inhibits Colony Formation of CB-5083-Resistant HCT116 Cells.
Feng Wang, Shan Li, William M Rosencrans, Kai-Wen Cheng, Gordon M Stott

ChemMedChem· June 2022

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Discovery of Potent Orally Bioavailable WD Repeat Domain 5 (WDR5) Inhibitors Using a Pharmacophore-Based Optimization.
Kevin B Teuscher, Kenneth M Meyers, Qiangqiang Wei, Jonathan J Mills, Jianhua Tian, Gordon M Stott

J Med Chem· April 2022

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Optimization of ether and aniline based inhibitors of lactate dehydrogenase.
Plamen P Christov, Kwangho Kim, Somnath Jana, Ian M Romaine, Ganesha Rai, Gordon M Stott

Bioorg Med Chem Lett· June 2021

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Discovery and Optimization of 2-1λ-Pyridin-2-one Inhibitors of Mutant Isocitrate Dehydrogenase 1 for the Treatment of Cancer.
Jason M Rohde, Surendra Karavadhi, Rajan Pragani, Li Liu, Yuhong Fang, Gordon M Stott

J Med Chem· April 2021

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Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.
Ganesha Rai, Daniel J Urban, Bryan T Mott, Xin Hu, Shyh-Ming Yang, Gordon M Stott

J Med Chem· October 2020

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Allosteric p97 Inhibitors Can Overcome Resistance to ATP-Competitive p97 Inhibitors for Potential Anticancer Therapy.
Feng Wang, Shan Li, Taiping Gan, Gordon M Stott, Andrew Flint

ChemMedChem· April 2020

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Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy.
Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R Brender, Gordon M Stott

Cell Rep· February 2020

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Discovery and Structure-Based Optimization of Potent and Selective WD Repeat Domain 5 (WDR5) Inhibitors Containing a Dihydroisoquinolinone Bicyclic Core.
Jianhua Tian, Kevin B Teuscher, Erin R Aho, Joseph R Alvarado, Jonathan J Mills, Gordon M Stott

J Med Chem· January 2020

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Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma.
Choh Yeung, Anna E Gibson, Sameer H Issaq, Nobu Oshima, Joshua T Baumgart, Gordon M Stott

Cancer Res· October 2019

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Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).
Ganesha Rai, Kyle R Brimacombe, Bryan T Mott, Daniel J Urban, Xin Hu, Gordon M Stott

J Med Chem· November 2017

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