Publications by authors named "Ilona Kariv"

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Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.
Wonsuk Chang, Michael D Altman, Charles A Lesburg, Samanthi A Perera, Jennifer A Piesvaux, Ilona Kariv

J Med Chem· April 2022

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Establishing and Validating Cellular Functional Target Engagement Assay for Selective IRAK4 Inhibitor Discovery.
Yiping Chen, Dongyu Sun, Ruojing Yang, Jongwon Lim, Christopher Sondey, Ilona Kariv

SLAS Discov· September 2021

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Development of High-Throughput Assays for Evaluation of Hematopoietic Progenitor Kinase 1 Inhibitors.
Brian M Lacey, Zangwei Xu, Xiaomei Chai, Jason Laskey, Xavier Fradera, Ilona Kariv

SLAS Discov· January 2021

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An orally available non-nucleotide STING agonist with antitumor activity.
Bo-Sheng Pan, Samanthi A Perera, Jennifer A Piesvaux, Jeremy P Presland, Gottfried K Schroeder, Ilona Kariv

Science· August 2020

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Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model.
Haiyan Xu, Eric S Muise, Sarah Javaid, Lan Chen, Razvan Cristescu, Ilona Kariv

J Cell Mol Med· October 2019

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Determination of EPAC2 function using EPAC2 null Min6 sublines generated through CRISPR-Cas9 technology.
Haiyan Xu, Yi Yang, Yiping Chen, Uwe Mueller, Sharanya Iyer, Ilona Kariv

Mol Cell Endocrinol· September 2018

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Evaluation of JAK3 Biology in Autoimmune Disease Using a Highly Selective, Irreversible JAK3 Inhibitor.
Fiona Elwood, David J Witter, Jennifer Piesvaux, Brian Kraybill, Nathan Bays, Ilona Kariv

J Pharmacol Exp Ther· May 2017

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Effect of cryopreservation on delineation of immune cell subpopulations in tumor specimens as determinated by multiparametric single cell mass cytometry analysis.
Elma Kadić, Raymond J Moniz, Ying Huo, An Chi, Ilona Kariv

BMC Immunol· February 2017

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Integration of Affinity Selection-Mass Spectrometry and Functional Cell-Based Assays to Rapidly Triage Druggable Target Space within the NF-κB Pathway.
Victoria D Kutilek, Christine L Andrews, Matthew P Richards, Zangwei Xu, Tianxiao Sun, Ilona Kariv

J Biomol Screen· July 2016

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Lead optimization of 4,4-biaryl piperidine amides as γ-secretase inhibitors.
Joshua Close, Richard Heidebrecht, John Hendrix, Chaomin Li, Ben Munoz, Ilona Kariv

Bioorg Med Chem Lett· May 2012

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Discovery of PDK1 kinase inhibitors with a novel mechanism of action by ultrahigh throughput screening.
Ekaterina V Bobkova, Michael J Weber, Zangwei Xu, Yan-Ling Zhang, Joon Jung, Ilona Kariv

J Biol Chem· June 2010

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MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
Bo-Sheng Pan, Grace K Y Chan, Melissa Chenard, An Chi, Lenora J Davis, Ilona Kariv

Cancer Res· February 2010

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Efficient identification of novel leads by dynamic focused screening: PDK1 case stud.
Dongyu Sun, Joon Jung, Thomas S Rush, Zangwei Xu, Michael J Weber, Ilona Kariv

Comb Chem High Throughput Screen· January 2010

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Development of high-throughput TR-FRET and AlphaScreen assays for identification of potent inhibitors of PDK1.
Zangwei Xu, Kumiko Nagashima, Dongyu Sun, Thomas Rush, Alan Northrup, Ilona Kariv

J Biomol Screen· December 2009

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A simplified scintillation proximity assay for fatty acid synthase activity: development and comparison with other FAS activity assays.
Nathan W Bays, Armetta D Hill, Ilona Kariv

J Biomol Screen· July 2009

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Design and implementation of an automated compound management system in support of lead optimization.
Catherine Quintero, Ilona Kariv

J Biomol Screen· June 2009

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Development of a cell-based assay for measurement of c-Met phosphorylation using AlphaScreen technology and high-content imaging analysis.
Nadya Smotrov, Anjili Mathur, Ilona Kariv, Christopher M Moxham, Nathan Bays

J Biomol Screen· April 2009

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High-throughput analysis of HGF-stimulated cell scattering.
Grace K Y Chan, Bart A Lutterbach, Bo-Sheng Pan, Ilona Kariv, Alexander A Szewczak

J Biomol Screen· October 2008

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From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: the discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis.
Joseph B Santella, Daniel S Gardner, Wenqing Yao, Chongsheng Shi, Prabhakar Reddy, Ilona Kariv

Bioorg Med Chem Lett· January 2008

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Quality control procedures for dose-response curve generation using nanoliter dispense technologies.
Catherine Quintero, Craig Rosenstein, Bethany Hughes, Richard Middleton, Ilona Kariv

J Biomol Screen· September 2007

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CC chemokine receptor-3 (CCR3) antagonists: improving the selectivity of DPC168 by reducing central ring lipophilicity.
James R Pruitt, Douglas G Batt, Dean A Wacker, Lori L Bostrom, Shon K Booker, Ilona Kariv

Bioorg Med Chem Lett· June 2007

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Use of optophoresis as an in vitro predictor of cell response to chemotherapy for chronic lymphocytic leukemia.
Michael Nerenberg, Ilona Kariv, Patricia McNeeley, Philippe Marchand, Sudipto Sur

Leuk Lymphoma· October 2006

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3-Aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase inhibitors.
Alexey Rivkin, Yoona R Kim, Mark T Goulet, Nathan Bays, Armetta D Hill, Ilona Kariv

Bioorg Med Chem Lett· September 2006

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Microfluidic sorting of mammalian cells by optical force switching.
Mark M Wang, Eugene Tu, Daniel E Raymond, Joon Mo Yang, Haichuan Zhang, Ilona Kariv

Nat Biotechnol· January 2005

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Use of moving optical gradient fields for analysis of apoptotic cellular responses in a chronic myeloid leukemia cell model.
Anita H Forster, Mark M Wang, William F Butler, Mirianas Chachisvilis, Thomas D Y Chung, Ilona Kariv

Anal Biochem· April 2004

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